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Synthetic Nanoparticles for Vaccines and Immunotherapy [PDF]
, 2015 The immune system plays a critical role in our health. No other component of human physiology plays a decisive role in as diverse an array of maladies, from deadly diseases with which we are all familiar to equally terrible esoteric conditions: HIV ...Adamina M., Ahn S., Alizadeh D., Alvarez I. B., Amanna I. J., Amigorena S., Anderson R. P., Arias M. a, Ataman-Onal Y., Bachmann M. F., Bachmann M. F., Bagchi A., Bal S. M., Banchereau J., Barhate G., Barhate G., Beduneau A., Beeton C., Benson D. M., Bershteyn A., Bertholon I., Black M., Blander J. M., Blander J. M., Bonnaud C., Brandtzaeg P., Broaders K. E., Brode S., Brown J. M., Burchill M. A., Bures P., Cario E., Carrasco Y. R., Centers for Disease Control and Prevention, Cerutti A., Cha E., Chabot S., Chabot S. M., Chackerian B., Chackerian B., Champion J. A., Champion J. A., Chang L.-J., Choi J., Chou L. Y. T., Clark R. A., Couzin-Frankel J., Crespo J., Cruz L. J., Cu Y., Darrell J. Irvine, Davis M. E., Davis M. J., De Titta A., Demento S. L., Demento S. L., Demento S. L., Deretic V., Desai M. P., Di Giacomo A. M., Dijkstra J. A. N., Dintzis H. M., Dintzis R. Z., Diwan M., Dolina J. S., Dostert C., Dou H., Dou H., Dudeja P. K., Duivenvoorden R., Eisenbarth S. C., Elamanchili P., Endsley A. N., Ensign L. M., Ensign L. M., Fahmy T. M., Fang R. H., Fernandez-Urrusuno R., Fievez V., Fife B. T., Fifis T., Fifis T., Foged C., Franchi L., Fraser C. C., Freeling J. P., Friede M., Fröhlich E., Gallucci S., Gatto D., Gebril A., Gerner M. Y., Getts D. R., Gharagozloo M., Gilliet M., Glenn G. M., Grupp S. A., Gungor B., Gupta P. N., Gupta P. N., Hajdu P., Hamad I., Hamdy S., Hamdy S., Hanlon D. J., Hanniffy S. B., Hanson M. C., Harde H., Harding C. V., Harding C. V., Harris J., Hasegawa T., Hejazi R., Helling F., Himeno A., Hirosue S., Hodi F. S., Hoffmann E., Hornung V., Hu Y., Hu Y., Hunter Z., Huynh N. T., Ilyinskii P. O., Ingale S., Irvine D. J., Ishii M., Iwasaki A., Iwasaki A., Iwasaki A., Jain S., Jain S., Janeway C. A., Jewell C. M., Jin B., Joffre O. P., Jones M.-C., Junt T., Kamaly N., Kaminskas L. M., Kasturi S. P., Kavya Rakhra, Kawai T., Keller S., Kim Y.-M., Kinman L., Kitaoka M., Klavinskis L. S., Klebanoff C. A., Kolaczkowska E., Kool M., Kourtis I. C., Kovacsovics-Bankowski M., Kovacsovics-Bankowski M., Kuo-Haller P., Kuznetsov V. A., Kwong B., Kwong B., Lai S. K., Lanzavecchia A., Laroui H., Lee I. H., Leonard J. P., Leuschner F., Li A. V., Li A. V., Li H., Li N., Li P., Lico C., Liu H., Liu Z., Locke L. W., Look M., Look M., Lv H., Mabbott N. A., Macho Fernandez E., Maeda H., Maier T., Maisel K., Maldonado R. a., Mandraju R., Manolova V., Martinez F. O., Matzinger P., Matzinger P., Maus M. V., Mbow M. L., McKee A. S., McNamara J. O., Melissa C. Hanson, Mellman I., Mellman I., Minguet S., Minguet S., Mishra D., Mittal A., Modery-Pawlowski C. L., Moghimi S. M., Mohri K., Moon J. J., Moon J. J., Moon J. J., Morefield G. L., Movahedi K., Moyano D. F., Moyle P. M., Mueller S. N., Mukai Y., Muraoka D., Murray P. J., Nakamura T., Nakamura T., Napolitani G., Nehaus V., Nembrini C., Ni X., Niikura K., Niu L., Nochi T., Nordly P., Ochiel D. O., Okada E., Okazaki T., Oussoren C., Oyewumi M. O., Panelli M. C., Panzarini E., Park J., Park J., Pasare C., Perica K., Perisé-Barrios A. J., Petersen L. K., Phan T. G., Pinheiro M., Plapied L., Ralli-Jain P., Rancan F., Rappuoli R., Ravindran R., Reddy S. T., Reddy S. T., Reis e Sousa C., Restifo N. P., Riese P., Rodríguez-Limas W. a., Rosalia R. A., Rosalia R. A., Russell D. G., Sah H., Salata O., Salman H. H., Saluja S. S., Sanders M. T., Sarma J. V., Sawaengsak C., Scheerlinck J.-P. Y., Schietinger A., Seong S.-Y., Serramía M. J., Sharp F. a, Shen H., Sheridan B. S., Shi C., Shima F., Silva A. L., Slütter B., Slütter B., Smirnov D., Smith B. R., Smith B. R., Smith D. M., Sneh-Edri H., Snyder A., Soboll G., Sokolova V., Solbrig C. M., St. John A. L., Stano A., Stano A., Stano A., Stefanick J. F., Stefanick J. F., Steinman R. M., Stephan M. T., Stephan M. T., Stylianou E., Sun B., Tacken P. J., Takano S., Talar Tokatlian, Tanaka Y., Taneichi M., Tang R., Temchura V. V., Thomas S. N., Thornton E. E., Tobio M., Tomita Y., Topalian S. L., Torres A. G., Tsai S., Tsai S., Tsai S., Tsuji K., Turley D. M., Ulery B. D., Vajdy M., Van der Vlies A. J., Van Lehn R. C., Van ’t Klooster G., Vanlandschoot P., Vicente S., Villa C. H., Vinay D. S., Waeckerle-Men Y., Waeckerle-Men Y., Walter S., Wang C., Wang T., Wang Y.-Y., Wang Z., Watson D. S., Weber J., Wijagkanalan W., Williams G. R., Wilson J. T., Wira C. R., Woodrow K. a., Wright H. L., Wu T. Y., Xia Y., Xiao Y., Xing Y., Xu J., Xu L., Xu Q.-H., Yan S., Yates R. M., Yeaman G. R., Yee C., Yeh T.-H., Yeste a., Yu S. S., Yuan H., Yuba E., Yuba E., Zeltins A., Zeng R., Zhang S., Zhang Z., Zheng Y., Zhu Q., Zhu Q., Zoete M. R. De +356 morecore +1 more sourceSynergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix
Advanced Functional Materials, EarlyView.This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor +7 morewiley +1 more sourceGuanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer. [PDF]
, 2017 INTRODUCTION: Colorectal cancer remains the second leading cause of cancer death in the United States, and new strategies to prevent, detect, and treat the disease are needed.Aka, Allison A., Pattison, Amanda M., Rappaport, Jeff A., Sato, Takami, Snook, Adam E., Waldman, Scott A. +5 morecore +2 more sourcesNext‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models
Advanced Functional Materials, EarlyView.Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker +30 morewiley +1 more sourceCochleates derived from Vibrio cholerae O1 proteoliposomes : The impact of structure transformation on mucosal immunisation [PDF]
, 2012 Cochleates are phospholipid-calcium precipitates derived from the interaction of anionic lipid vesicles with divalent cations. Proteoliposomes from bacteria may also be used as a source of negatively charged components, to induce calcium-cochleate ...Adriana Callicó, Alexander B. Mullen, Bárbara Cedré, Caridad Zayas, David Mckee, Gunnar F. Kaufmann, José L. Pérez, Luis García, Oliver Pérez, Reinaldo Acevedo, Valerie A. Ferro +10 morecore +3 more sourcesInactivating SARS‐CoV‐2 Virus with MOF‐Composites as Smart Face Masks
Advanced Functional Materials, EarlyView.In situ preparation and functionalization of MOF@Cotton fabrics as smart face masks for the immobilization of proteins and inactivation viruses, such as SARS‐CoV‐2. Abstract
The significant impact of the SARS‐CoV‐2 (COVID‐19) pandemic outbreak on people's lives has highlighted the urgent need for effective personal protective equipment.Romy Ettlinger, Aamod V. Desai, Hau Lam Jody Cheong, Louise L. Major, Terry K. Smith, Aaron B. Naden, Jane Hilton, Catherine S. Adamson, A. Robert Armstrong, Russell E. Morris +9 morewiley +1 more sourceThe Use of Synthetic Carriers in Malaria Vaccine Design
Vaccines, 2015 Malaria vaccine research has been ongoing since the 1980s with limited success. However, recent improvements in our understanding of the immune responses required to combat each stage of infection will allow for intelligent design of both antigens and ...Liam Powles, Sue D. Xiang, Cordelia Selomulya, Magdalena Plebanski +3 moredoaj +1 more source
