Results 1 to 10 of about 39,691 (119)
Attenuation of Vaccinia Virus [PDF]
Acta Naturae, 2015 Since 1980, in the post-smallpox vaccination era the human population has become increasingly susceptible compared to a generation ago to not only the variola (smallpox) virus, but also other zoonotic orthopoxviruses. The need for safer vaccines against orthopoxviruses is even greater now.
YAKUBITSKIY S.N. +3 more
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Enhancing the Immunogenicity of Vaccinia Virus
Viruses, 2022 The conventional live smallpox vaccine based on the vaccinia virus (VACV) cannot be widely used today because it is highly reactogenic. Therefore, there is a demand for designing VACV variants possessing enhanced immunogenicity, making it possible to reduce the vaccine dose and, therefore, significantly eliminate the pathogenic effect of the VACV on ...
Sergei N. Shchelkunov +11 more
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Morphological Structure of the Virus of Vaccinia [PDF]
Experimental Biology and Medicine, 1942 The pictorial data obtained by means of the electron microscope indicate a remarkable regularity in the morphology of the elementary body of vaccinia. The virus particles apparently have internal structure and some sort of limiting membrane.
Thomas F. Anderson +2 more
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Vaccinia virus proteolysis—a review [PDF]
Reviews in Medical Virology, 2006 AbstractIt is well known that viruses, as obligate intracellular parasites, must use their hosts' metabolic machinery in order to replicate their genomes and form infectious progeny virions. What is less well known are the details of how viruses make sure that once all the necessary proteins are made, that they assume the correct configuration at the ...
Chelsea M. Byrd +2 more
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Studies on the Structure of Vaccinia Virus [PDF]
Journal of General Microbiology, 1964 SUMMARY: Vaccinia virus has been examined with the electron microscope by several techniques in conjunction with experimental modifications of structure. Negative staining revealed that over 80% of the virus in highly purified preparations were particles which appeared to have a beaded surface like a mulberry and were termed M forms.
H. T. Zwartouw +4 more
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Purification of Vaccinia Virus
American Journal of Public Health and the Nations Health, 1934 THE success attained by chemists in preparing purified or concentrated extracts of tissue containing enzymes and other biological products has stimulated similar attempts upon the tissues of animals infected with filterable viruses.1 2 8 The virus of vaccinia has received considerable attention in this respect, due in part perhaps to the economy and ...
Morris Schaeffer, Helen Nalibow
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Lack of Transmission of Vaccinia Virus
Emerging Infectious Diseases, 2006 To the Editor: Recently, the US government completed a targeted vaccination strategy limited to healthcare workers, first responders, and the military because of concern that variola virus, the etiologic agent of smallpox, might be used as a biowarfare agent (1).
Paul S. Blum +3 more
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Origin of the Vaccinia Virus Hemagglutinin [PDF]
Journal of Virology, 1972 The relationship between the vaccinia virus hemagglutinin and hemadsorption was examined. Hemagglutinin synthesis was temporally related to the appearance of the hemadsorption reaction. Only chicken erythrocytes, which reacted with hemagglutinin, hemadsorbed to infected cells, and both of these reactions were inhibited by Ca 2+
Kenneth E. Blackman, H. Curt Bubel
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Eclipse Phase of Vaccinia Virus [PDF]
Nature, 1960 THE development of a plaque technique for titrating vaccinia virus on monolayers of chick embryo cells without an agar overlay1 has furthered the investigation of cell-virus interaction in this system and has produced evidence of an ‘eclipse phase’ under certain experimental conditions. The essential prerequisite was that the inoculum, consisting of an
H. B. Maitland, R Postlethwaite
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Advanced Science, EarlyView.SCORT–Cas13d–pre‐gHoxB13 lipid nanoparticles precisely deliver Cas13d mRNA and guide RNAs to metastatic prostate tumors in the liver, knocking down the “undruggable” transcription factor HoxB13. This approach suppresses metastatic tumor growth, extends mouse survival, and does not induce major organ toxicity or immune activation, offering a safe and ...
Zhifen Cui +15 more
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