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Group 2 Vaccinia Virus, Brazil
Emerging Infectious Diseases, 2012 In 2011, vaccinia virus caused an outbreak of bovine vaccinia, affecting dairy cattle and dairy workers in Brazil. Genetic and phenotypic analyses identified this isolate as distinct from others recently identified, thereby reinforcing the hypothesis ...
Felipe Lopes Assis +9 more
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Temporal expression classes and functions of vaccinia virus and mpox (monkeypox) virus genes [PDF]
mBioPoxviruses comprise pathogens that are highly pathogenic to humans and animals, causing diseases such as smallpox and mpox (formerly monkeypox). The family also contains members developed as vaccine vectors and oncolytic agents to fight other diseases ...
Yining Deng +2 more
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Microbiology Spectrum, 2023 In addition to the 3′-poly(A) tail, vaccinia virus mRNAs synthesized after viral DNA replication (post-replicative mRNAs) possess a 5′-poly(A) leader that confers a translational advantage in virally infected cells.
Pragyesh Dhungel +2 more
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Vaccinia virus-based vector against infectious diseases and tumors
Human Vaccines & Immunotherapeutics, 2021 Vaccinia virus was used to prevent smallpox. After the World Health Organization declared smallpox extinct, vaccinia virus has been explored for the development of vaccines against a variety of infectious diseases.
Ziling Zhang +5 more
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Attenuation of Vaccinia Virus [PDF]
Acta Naturae, 2015 Since 1980, in the post-smallpox vaccination era the human population has become increasingly susceptible compared to a generation ago to not only the variola (smallpox) virus, but also other zoonotic orthopoxviruses. The need for safer vaccines against orthopoxviruses is even greater now.
YAKUBITSKIY S.N. +3 more
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Biomedicines, 2020 As a live biologic agent, oncolytic vaccinia virus has the ability to target and selectively amplify at tumor sites. We have previously reported that deletion of thymidine kinase and ribonucleotide reductase genes in vaccinia virus can increase the ...
Franck Gallardo +14 more
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Vaccinia E5 is a major inhibitor of the DNA sensor cGAS
Nature Communications, 2023 The DNA sensor cyclic GMP-AMP synthase (cGAS) is critical in host antiviral immunity. Vaccinia virus (VACV) is a large cytoplasmic DNA virus that belongs to the poxvirus family.
Ning Yang +11 more
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MethodsX, 2020 Vaccinia virus is capable of replicating in a wide range of vertebrate animal cells. However, deletion of the two virus host range genes, E3L and K3L, would render replication of the virus abortive in all the cell types tested, except the cells with ...
Jingxin Cao +3 more
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Incomplete but infectious vaccinia virions are produced in the absence of oncolysis in feline SCCF1 cells. [PDF]
PLoS ONE, 2015 Vaccinia virus is a large, enveloped virus of the poxvirus family. It has broad tropism and typically virus replication culminates in accumulation and lytic release of intracellular mature virus (IMV), the most abundant form of infectious virus, as well ...
Suvi Parviainen +7 more
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An Update on the Known Host Range of the Brazilian Vaccinia Virus: An Outbreak in Buffalo Calves
Frontiers in Microbiology, 2019 Even nearly forty years after the eradication of smallpox, members of the Poxviridae family continue to be the focus of an increasing number of studies.
Mauricio Teixeira Lima +7 more
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