Results 31 to 40 of about 1,775,772 (324)

Identification of sites phosphorylated by the vaccinia virus B1R kinase in viral protein H5R [PDF]

, 2000
Background: Vaccinia virus gene B1R encodes a erine/threonine protein kinase. In vitro this protein kinase phosphorylates ribosomal proteins Sa and S2 and vaccinia virus protein H5R, proteins that become phosphorylated during infection.
Beaud, G., Brown, N.G., Hardie, G., Leader, D.P., Morrice, D.N.   +4 more
core   +3 more sources

Shared determinants between virus-infected and trinitrophenyl-conjugated H-2-identical target cells detected in cell-mediated lympholysis [PDF]

, 1976
Infection of H-2-identical mice with either lymphocytic choriomeningitis (LCM) virus, vaccinia virus, or paramyxo (Sendai) virus resulted in the generation of specifically sensitized cytotoxic T lymphocytes (CTL).
Bevan, Canty, Doherty, Doherty, Ertl, Forman, Gordon, Herberman, Koszinowski, Pfizenmaier, Pfizenmaier, Pfizenmaier, Shearer, Shreffler, Wagner, Wekerle, Zinkernagel   +16 more
core   +1 more source

Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy

Nature Communications, 2017
Both anti-PD1/PD-L1 therapy and oncolytic virotherapy have demonstrated promise, yet have exhibited efficacy in only a small fraction of cancer patients. Here we hypothesized that an oncolytic poxvirus would attract T cells into the tumour, and induce PD-
Zuqiang Liu, Roshni Ravindranathan, P. Kalinski, Z. Guo, David L. Bartlett   +4 more
semanticscholar   +1 more source

Construction of three strains of recombinant oncolytic vaccinia virus and their anti-tumor activity [PDF]

Jichu yixue yu linchuang, 2020
Objective The aim of this study is to construct a recombinant oncolytic vaccinia virus with CCL5 and SSTR2 genes and to detect its antitumor activity. Methods Recombinant vaccinia virus eukaryotic expression plasmid pSC65-CCL5-SSTR2-Luc+ was constructed.
LI Dan-yang, FANG Jing-jing, TANG Hui
doaj  

Correlative analysis from a phase I clinical trial of intrapleural administration of oncolytic vaccinia virus (Olvi-vec) in patients with malignant pleural mesothelioma

Frontiers in Immunology, 2023
BackgroundThe attenuated, genetically engineered vaccinia virus has been shown to be a promising oncolytic virus for the treatment of patients with solid tumors, through both direct cytotoxic and immune-activating effects.
Navin K. Chintala, Jennie K. Choe, Erin McGee, Rebecca Bellis, Jasmeen K. Saini, Srijita Banerjee, Andre L. Moreira, Marjorie G. Zauderer, Prasad S. Adusumilli, Prasad S. Adusumilli, Valerie W. Rusch   +10 more
doaj   +1 more source

Asparagine Is a Critical Limiting Metabolite for Vaccinia Virus Protein Synthesis during Glutamine Deprivation

Journal of Virology, 2019
Viruses rely on their infected host cells to provide nutrients and energy for replication. Vaccinia virus, the prototypic member of the poxviruses, which comprise many significant human and animal pathogens, prefers glutamine to glucose for efficient ...
Anil Pant, Shuai Cao, Zhilong Yang
semanticscholar   +1 more source

Vaccinia Virus Infections in Martial Arts Gym, Maryland, USA, 2008

Emerging Infectious Diseases, 2011
Vaccinia virus is an orthopoxvirus used in the live vaccine against smallpox. Vaccinia virus infections can be transmissible and can cause severe complications in those with weakened immune systems.
Christine M. Hughes, David Blythe, Yu Li, Ramani Reddy, Carol Jordan, Cindy Edwards, Celia Adams, Holly Conners, Catherine Rasa, Sue Wilby, Jamaal Russell, Kelly S. Russo, Patricia Somsel, Danny L. Wiedbrauk, Cindy Dougherty, Christopher Allen, Mike Frace, Ginny L. Emerson, Victoria A. Olson, Scott K. Smith, Zachary Braden, Jason Abel, Whitni Davidson, Mary G. Reynolds, Inger K. Damon   +24 more
doaj   +1 more source

The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility [PDF]

, 2013
Vaccinia virus dissemination relies on the N-WASP– ARP2/3 pathway, which mediates actin tail formation underneath cell-associated extracellular viruses (CEVs).
Alberts, Alvarez, Arakawa, Bagrodia, Bernardini, Block, Boujemaa-Paterski, Chong, Chong, Diego E. Alvarez, Earl, Engelstad, Feig, Frischknecht, Fukuoka, Gasteier, Goldberg, Haglund, Hannemann, Harris, Harris, Heindl, Hervé Agaisse, Hiller, Hollinshead, Hoppe, Humphries, Isaacs, Katz, Kleba, Koka, Kovar, Krall, Lammers, Lasa, Li, Madrid, Moseley, Moseley, Newsome, Newsome, Nezami, Otomo, Parkinson, Pollard, Pring, Pruyne, Qiu, Ridley, Rietdorf, Roberts, Rolls, Romero, Röttger, Sanderson, Scaplehorn, Schmelz, Schulte, Schönichen, Schönichen, Serio, Shibata, Siripala, Skoble, Smith, Suzuki, Takeya, Tooze, van Eijl, van Eijl, Wallar, Ward, Ward, Watanabe, Weisswange, Welch, Westendorf, Westendorf, Wolffe, Wolffe   +79 more
core   +2 more sources

Vaccinia virus hijacks EGFR signalling to enhance virus spread through rapid and directed infected cell motility

Nature Microbiology, 2018
Cell motility is essential for viral dissemination1. Vaccinia virus (VACV), a close relative of smallpox virus, is thought to exploit cell motility as a means to enhance the spread of infection1.
Corina Beerli, A. Yakimovich, S. Kilcher, Glennys V. Reynoso, Gotthold Fläschner, D. Müller, H. Hickman, J. Mercer   +7 more
semanticscholar   +1 more source

Antitumor efficacy of cytosine deaminase-armed vaccinia virus plus 5-fluorocytosine in colorectal cancers

Cancer Cell International, 2020
Background Vaccinia viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability of tumor tropism and oncolytic property.
Yuedi Ding, Jun Fan, Lili Deng, Biao Huang, Bin Zhou   +4 more
doaj   +1 more source