Results 61 to 70 of about 1,739,286 (305)

Evaluation of Monkeypox- and Vaccinia virus-neutralizing antibodies in human serum samples after vaccination and natural infection

Frontiers in Public Health, 2023
IntroductionIn early to mid-2022, an unexpected outbreak of Monkeypox virus infections occurred outside the African endemic regions. Vaccines originally developed in the past to protect against smallpox are one of the available countermeasures to prevent
Alessandro Manenti, Niccolò Solfanelli, Paolo Cantaloni, Livia Mazzini, Margherita Leonardi, Margherita Leonardi, Linda Benincasa, Giulia Piccini, Serena Marchi, Martina Boncioli, Chiara Spertilli Raffaelli, Danilo Tacconi, Giada Mattiuzzo, Otfried Kistner, Emanuele Montomoli, Emanuele Montomoli, Emanuele Montomoli, Claudia Maria Trombetta, Claudia Maria Trombetta   +18 more
doaj   +1 more source

MVA-based H5N1 vaccine affords cross-clade protection in mice against influenza A/H5N1 viruses at low doses and after single immunization. [PDF]

, 2009
Human infections with highly pathogenic avian influenza viruses of the H5N1 subtype, frequently reported since 2003, result in high morbidity and mortality.
Amerongen, Geert van, Brand, Judith M. A. van den, Fouchier, Ron A. M., Kreijtz, Joost H. C. M., Löwer, Johannes, Mutsert, Gerrie de, Osterhaus, Albert D. M. E., Rimmelzwaan, Guus F., Schwantes, Astrid, Suezer, Yasemin, Sutter, Gerd   +10 more
core   +7 more sources

Studies on processing, particle formation, and immunogenicity of the HIV-1 gag gene product: a possible component of a HIV vaccine [PDF]

, 1992
Antigens in a particulate conformation were shown to be highly immunogenic in mammals. For this reason, the particle forming capacity of derivatives of the HIV-1 group specific core antigen p55 gag was assayed and compared dependent on various expression
Deby, G., Fliessbach, H., Motz, M., Niedrig, M., von Brunn, A., Wagner, R., Wanner, G., Wolf, Hans J.   +7 more
core   +1 more source

Generation of recombinant mAbs to vaccinia virus displaying high affinity and potent neutralization

Microbiology Spectrum, 2023
Members of the Orthopoxvirus genus can cause severe infections in humans. Global vaccination against smallpox, caused by the variola virus, resulted in the eradication of the disease in 1980.
Tal Noy-Porat, Hadas Tamir, Ron Alcalay, Ronit Rosenfeld, Eyal Epstein, Lilach Cherry, Hagit Achdout, Noam Erez, Boaz Politi, Yfat Yahalom-Ronen, Shay Weiss, Sharon Melamed, Tomer Israely, Ohad Mazor, Nir Paran, Efi Makdasi   +15 more
doaj   +1 more source

Ribosome Profiling Reveals Translational Upregulation of Cellular Oxidative Phosphorylation mRNAs during Vaccinia Virus-Induced Host Shutoff

Journal of Virology, 2016
Vaccinia virus infection causes a host shutoff that is marked by global inhibition of host protein synthesis. Though the host shutoff may facilitate reallocation of cellular resources for viral replication and evasion of host antiviral immune responses ...
Aimei Dai, Shuai Cao, Pragyesh Dhungel, Yizhao Luan, Yizhi Liu, Zhi Xie, Zhilong Yang   +6 more
semanticscholar   +1 more source

Vaccinia virus binds to the scavenger receptor MARCO on the surface of keratinocytes. [PDF]

, 2015
Patients with altered skin immunity, such as individuals with atopic dermatitis (AD), can have a life-threatening disruption of the epidermis known as eczema vaccinatum after vaccinia virus (VV) infection of the skin. Here, we sought to better understand
di Nardo, Anna, Gallo, Richard L, MacLeod, Daniel T, Nakatsuji, Teruaki, Wang, Zhenping   +4 more
core   +2 more sources

Polymeric Cups for Cavitation-mediated Delivery of Oncolytic Vaccinia Virus

Molecular Therapy, 2016
Oncolytic viruses (OV) could become the most powerful and selective cancer therapies. However, the limited transport of OV into and throughout tumors following intravenous injection means their clinical administration is often restricted to direct ...
Rachel Myers, C. Coviello, P. Erbs, Johann Foloppe, C. Rowe, J. Kwan, C. Crake, S. Finn, E. Jackson, J. Balloul, Colin Story, C. Coussios, R. Carlisle   +12 more
semanticscholar   +1 more source

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, EarlyView.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source

Vaccinia protein C16 blocks innate immune sensing of DNA by binding the Ku complex [PDF]

, 2011
VACV gene C16L encodes a 37-kDa protein that is highly conserved in orthopoxviruses and functions as an immunomodulator. Intranasal infection of mice with a virus lacking C16L (vΔC16) induced less weight loss, fewer signs of illness and increased ...
Peters, Nicholas Edward, Peters, Nicholas Edward   +1 more
core   +1 more source

Set of Vectors for the Expression of Histidine-Tagged Proteins in Vaccinia Virus Recombinants

BioTechniques, 2001
Vaccinia virus expression vectors are widely used to direct the expression of proteins in eukaryotic cells. Here, we describe a new set of plasmid vectors designed for the expression of histidine-tagged proteins in the vaccinia system.
Inmaculada Galindo, María M. Lorenzo, Rafael Blasco   +2 more
doaj   +1 more source