Results 61 to 70 of about 43,735 (192)

The vaccinia virus K7 protein promotes histone methylation associated with heterochromatin formation. [PDF]

PLoS ONE, 2017
It has been well established that many vaccinia virus proteins suppress host antiviral pathways by targeting the transcription of antiviral proteins, thus evading the host innate immune system. However, whether viral proteins have an effect on the host's
Wondimagegnehu M Teferi, Megan A Desaulniers, Ryan S Noyce, Mira Shenouda, Brittany Umer, David H Evans   +5 more
doaj   +1 more source

Electric Method for the Desulfation of Polysaccharides From Red Microalgae (Porphyridium cruentum) Cultures

Biopolymers, Volume 117, Issue 2, March 2026.
A non‐destructive method for depleting sulfates from the red microalgae Porphyridium cruentum by directly exposing the growth medium to a moderate electric field has been developed. The reported electric‐field separation method is a simple, straightforward, and non‐toxic means for the direct recovery of desulfated polysaccharides from P.
Oshrat Levy‐Ontman, Amikam Bar‐Gil, Eli Shemesh, Mahmoud Huliehel, Yehudit Amor, Naama Landes, Yonatan Sadeh, Dan Tchernov   +7 more
wiley   +1 more source

An Ad26‐MVA‐BN‐based therapeutic vaccine targeting HPV16 and HPV18 related disease is immunogenic in preclinical models and in women with persistent HPV infections

Clinical &Translational Immunology, Volume 15, Issue 3, March 2026.
Immunisation with adenovirus (Ad) vectors followed by Modified Vaccinia Virus Ankara—strain Bavarian Nordic (MVA‐BN) vectors expressing HPV16 and HPV18 engineered antigens induced antigen‐specific polyfunctional T cells in mice, rhesus macaques and persistent HPV16/HPV18 infected human females vaccines (n = 5). These data showed the promise of the Ad26‐
Selina Khan, Satish Boedhoe, Miranda Baert, Jan Serroyen, Thierry Verbinnen, Ariane Volkmann, Markus Kalla, Katrin Weidner, Mathieu Le Gars, Jerry Sadoff, Michal Sarnecki, Jort Vellinga, Jerome Custers, Gert Scheper, Hanneke Schuitemaker, Roland Zahn   +15 more
wiley   +1 more source

Mpox (Monkeypox) in Pregnancy Updates

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Mpox is a zoonotic viral disease caused by the monkeypox virus, with potential for significant morbidity across all population groups, including pregnant individuals and neonates. Pregnancy represents an immunologically vulnerable state, rendering affected mothers more susceptible to severe disease progression.
Yeshey Dorjey, Deep Kiran Chhetri
wiley   +1 more source

Eczema Monkeypoxicum Following Sexual Transmission Treated With Tecovirimat

JEADV Clinical Practice, Volume 5, Issue 1, Page 250-253, March 2026.
Capsule summary Mpox is a zoonotic infection that may present severe dissemination in patients with pre‐existing dermatoses. We report a 30‐year‐old man with active atopic dermatitis who developed extensive, sexually transmitted mpox with widespread cutaneous involvement consistent with eczema monkeypoxicum.
Andrés Vidal González, Sergio López Alcázar, José Ángel Amat Sánchez, Francisco Vergara Barria, Rosa Feltes Ochoa, Elena Sendagorta Cudos, Pedro Herranz Pinto   +6 more
wiley   +1 more source

BiZyme: A Novel Fusion Protein-Mediating Selection of Vaccinia Virus Recombinants by Fluorescence and Antibiotic Resistance

BioTechniques, 2002
Recombinant vaccinia virus is a useful and powerful tool for the expression and study of foreign genes. Methods that are currently available for the selection of vaccinia virus recombinants include the restoration of viral plaque-forming phenotype, the ...
Scott G. Hansen, Torrey A. Cope, Dennis E. Hruby   +2 more
doaj   +1 more source

Serological Immunity to Smallpox in New South Wales, Australia

Viruses, 2020
The re-emergence of smallpox is an increasing and legitimate concern due to advances in synthetic biology. Vaccination programs against smallpox using the vaccinia virus vaccine ceased with the eradication of smallpox and, unlike many other countries ...
Valentina Costantino, Mallory J. Trent, John S. Sullivan, Mohana P. Kunasekaran, Richard Gray, Raina MacIntyre   +5 more
doaj   +1 more source

Immune Exhaustion in Chronic Infection and Cancer: Signaling Pathways and Therapeutic Interventions

MedComm, Volume 7, Issue 3, March 2026.
Immune exhaustion is a well‐established hallmark of both cancer and chronic infection. This review proposes a novel “infection–exhaustion–tumor axis” framework, wherein chronic pathogens (e.g., oncogenic viruses) evade immune surveillance by hijacking inflammatory signaling to drive immune cell exhaustion, thereby creating immunosuppressive niches ...
Yali Song, Yazhi Mo, Si Chen, Yuemei Chen, Chunying Zhang, Shanying Deng, Juan Liao, Yi He, Wei Wang, Weidong Zheng, Tingting Zeng   +10 more
wiley   +1 more source

Outbreak of Severe Zoonotic Vaccinia Virus Infection, Southeastern Brazil

Emerging Infectious Diseases, 2015
In 2010, a vaccinia virus isolate caused an atypically severe outbreak that affected humans and cattle in Brazil. Of 26 rural workers affected, 12 were hospitalized.
Jônatas Santos Abrahão, Rafael Kroon Campos, Giliane de Souza Trindade, Flávio Guimarães da Fonseca, Paulo César Peregrino Ferreira, Maurício Teixeira Lima   +5 more
doaj   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source