Results 71 to 80 of about 43,735 (192)

Mpox Outbreak in the East Africa Region: Current Status, Containment Measures, Challenges, and Future Direction

Public Health Challenges, Volume 5, Issue 1, March 2026.
The WHO declares the Mpox outbreak a Public Health Emergency of International Concern, with the DRC as the epicenter in the EAC. DRC, Uganda, and Burundi experience extensive transmission; Kenya and Uganda show higher case fatality rates. Containment measures include surveillance, public awareness, infection prevention training, and vaccination (>73 ...
Reuben Sindayiheba, Noel Gahamanyi, Jerome Ndayisenga, Edouard Ntagwabira, Emmanuel Nsengiyumva, Emmanuel Kabalisa, Gashegu Misbah, Isabelle Mukagatare, Leon Mutesa, Claude Mambo Muvunyi   +9 more
wiley   +1 more source

Study of the protective properties of immunodominant proteins of orthopoxviruses in various methods of immunization

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. In 2022, the World Health Organization declared monkeypox a public health emergency. The monkeypox virus (MPV) is part of the Orthopoxvirus genus within the Poxviridae family.
Denis I. Zrelkin, Olga V. Zubkova, Tatiana A. Ozharovskaia, Olga Popova, Daria V. Voronina, Polina P. Goldovskaya, Irina V. Vavilova, Anastasia S. Chugunova, Inna V. Dolzhikova, Dmitry N. Shcherbinin, Dmitry V. Shcheblyakov, Denis Y. Logunov, Alexander L. Gintsburg   +12 more
doaj   +1 more source

Clinical signs, diagnosis, and case reports of Vaccinia virus infections

Brazilian Journal of Infectious Diseases, 2010
Vaccinia virus is responsible for a zoonosis that usually affects cattle and human beings in Brazil. The initial clinical signs of the infection are focal red skin areas, fever, and general symptoms similar to those of a cold.
Daniela Carla Medeiros-Silva, Eduardo Augusto dos Santos Moreira-Silva, Juliana de Assis Silva Gomes, Flávio Guimarães da Fonseca, Rodrigo Correa-Oliveira   +4 more
doaj   +1 more source

Ensemble Docking of FDA‐Approved and Peruvian Phytochemicals Against Monkeypox Virus Telomere‐Binding Protein

ChemistrySelect, Volume 11, Issue 9, 5 March 2026.
ABSTRACT Monkeypox is a reemerging zoonotic disease that has been spreading worldwide. Different approaches are being conducted to find effective treatments for this disease. To accelerate therapeutic discovery, we propose telomere‐binding protein (TBP) as a potential drug target because of its important role during virus maturation.
Edinson Gervacio‐Villarreal, Georcki Ropón‐Palacios, Claudina Sancho, Jhon Pérez‐Silva, Kewin Otazu, Gustavo E. Olivos‐Ramirez, Karolyn Vega‐Chozo, Yaritza L. Ramirez‐Díaz, Manuel E. Chenet‐Zuta, Ivonne Navarro del Aguila, Mario De la Cruz Flores, Cinthia Aguiar, Ihosvany Camps   +12 more
wiley   +1 more source

Association of Haematological Parameters With TLR Genes in Healthy and Distemper‐Infected Dogs Haematology and TLRs in Distemper

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
The distemper‐infected dogs presented with an upregulated expression of the immune recognition receptors TLR3, TLR4 and TLR9. In the distemper‐infected dogs, there was a positive correlation between the TLR1 and PWD, TLR4 and WBC, Gran and Gran%, TLR5 and HCT, TLR6 and Gran%, TLR7 and MCV and TLR7 and PDW, as well as a negative correlation between the ...
İlknur Karaca Bekdik, Fadime Daldaban, Korhan Arslan, Bilal Akyüz, Öznur Aslan   +4 more
wiley   +1 more source

Comparison of Safety and Vector-Specific Immune Responses in Healthy and HIV-Infected Populations Vaccinated with MVA-B

Vaccines, 2019
There are few studies comparing the safety and immunogenicity of the same HIV immunogen in healthy volunteers and HIV-infected individuals. We analyzed demographics, adverse events (AEs), and immunogenicity against vaccinia virus in preventive (RISVAC02,
Elvira Couto, Vicenç Diaz-Brito, Beatriz Mothe, Alberto C. Guardo, Irene Fernandez, Ainoa Ugarte, Flor Etcheverry, Carmen E. Gómez, Mariano Esteban, Judit Pich, Joan Albert Arnaiz, Juan Carlos López Bernaldo de Quirós, Christian Brander, Montserrat Plana, Felipe García, Lorna Leal   +15 more
doaj   +1 more source

Mpox and the Ethics of Outbreak Management: Lessons for Future Public Health Crises

Developing World Bioethics, Volume 26, Issue 1, Page 43-49, March 2026.
ABSTRACT Mpox, first identified in captive monkeys in 1958 and recognized in humans by 1970 in the Democratic Republic of Congo, was historically confined to sporadic zoonotic outbreaks in Central and West Africa. These outbreaks, often driven by rodent‐to‐human transmission in resource‐limited settings, reflect persistent systemic health disparities ...
Adetayo E. Obasa, Marietjie Botes, Anita Kleinsmidt, Ciara Staunton   +3 more
wiley   +1 more source

Intracellular Development of Vaccinia Virus.

Experimental Biology and Medicine, 1952
Summary1. Electron micrographs of tissue sections of chorioallantoic membrane infected with vaccinia virus were examined. Some cells were found to be almost filled with virus, others contained the virus particles grouped in single inclusions of varying sizes.
W H, GAYLORD, J L, MELNICK, H, BUNTING
openaire   +2 more sources

Sex Differences in Response to Viral Vector Vaccines—Implications for Future Vaccine Design

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Vaccination represents one of the most impactful public health achievements, preventing 3.5 to 5 million deaths annually according to estimates of the World Health Organization. Yet, recent outbreaks of emerging and reemerging infectious diseases highlight the need for rapid and strategic vaccine development using vaccine platforms ...
Ilka Grewe, Tamara Zoran, Marylyn Martina Addo   +2 more
wiley   +1 more source

The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease

Journal of Internal Medicine, Volume 299, Issue 3, Page 328-348, March 2026.
Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Annelise E. Barron, Jennifer S. Lin, Mark I. Ryder, Peter Bergman   +3 more
wiley   +1 more source