Results 141 to 150 of about 225,375 (330)

Intricate Regulation of Sphingolipid Biosynthesis: An In‐Depth Look Into ORMDL‐Mediated Regulation of Serine Palmitoyltransferase

open access: yesBioEssays, EarlyView.
Multiple enzymes play a crucial role in regulating the biosynthesis of de novo sphingolipids. This regulation starts with the rate‐limiting enzyme, serine palmitoyltransferase (SPT), which catalyzes the first step of the pathway. Disruptions in this regulatory process can lead to serious diseases.
Usha Mahawar, Binks Wattenberg
wiley   +1 more source

UTILIZATION OF VALINE IN THE BIOSYNTHESIS OF PENICILLINS [PDF]

open access: yesJournal of Biological Chemistry, 1954
Pran Vohra   +2 more
openaire   +2 more sources

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers

open access: yesBMEMat, EarlyView.
Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen   +7 more
wiley   +1 more source

Flavonoid Profile, Biological Potentials, and In Silico Approaches of Methanol Extracts on AChE: Amaranthus retroflexus L.

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT This study investigated the flavonoid compounds and their biological activities in methanol extracts obtained from root, stem, leaf, and flower parts of Amaranthus retroflexus L. Flavonoids in the extracts were characterized for the first time by liquid chromatography–highresolution mass spectrometry (LC–HRMS), and a total of eight flavonoid ...
Bedrettin Selvi   +6 more
wiley   +1 more source

Synthesis of Nucleoside Derivatives by Biomimetic Ester Migration

open access: yesChemBioChem, EarlyView.
In tRNA aminoacylated nucleosides represent the central transfer unit of amino acids. An occurring 2′‐3′‐transaminoacylation is biomimetically exploited to successfully synthesize nucleosidic acid esters. This approach can be further expanded on sulfonic acid esters, which has the potential of a broad range of stereo‐ and regio‐controlled modifications
Nathalie J. Kurrle   +8 more
wiley   +1 more source

Advances in Ligand‐Driven Pd‐Catalyzed C─H Functionalizations: Recent Insights and Updates

open access: yesChemCatChem, EarlyView.
The most significant advances in ligand‐driven Pd‐catalyzed organic synthesis over the past two years are presented. Processes involving C─H activation of substrates, avoiding their prefunctionalization are illustrated. Both the activity and selectivity of the catalyst depend on the design of the ligands (pyridones, pyridines, amino acids, phosphines ...
Jesús Moradell   +3 more
wiley   +1 more source

ORIGIN OF THE CARBON SKELETONS OF ISOLEUCINE AND VALINE

open access: hybrid, 1951
E. L. Tatum, Edward A. Adelberg
openalex   +1 more source

RNA codewords and protein synthesis, 8. Nucleotide sequences of synonym codons for arginine, valine, cysteine, and alanine. [PDF]

open access: green, 1965
Richard Brimacombe   +5 more
openalex   +1 more source

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