Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Spatiotemporal patterns and drivers of population and transport coordination in the Pearl River Delta. [PDF]
Lyu D, Zhu W, Ouyang L, Gong Z.
europepmc +1 more source
A Modified Variable Structure Control Algorithm for Stabilization of Uncertain Dynamical Systems
Zanasi, Roberto
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Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Változó struktúrájú nemlineáris szabályozott teljesítményelektronikai rendszerek elméleti kérdései = Theoretical problems of variable structure nonlinear feedback systems in power electronics [PDF]
István Nagy +7 more
openalex
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath +3 more
wiley +1 more source
All together now: Random Forests analysis reveals the joint impact of multiple statistical regularities on eye-movements during reading. [PDF]
Kimchi I, Siegelman N.
europepmc +1 more source
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst +4 more
wiley +1 more source
Properties of Residual Cumulative Sharma-Taneja-Mittal Model and Its Extensions in Reliability Theory with Applications to Human Health Analysis and Mixed Coherent Mechanisms. [PDF]
Mohamed MS, Sakr HH.
europepmc +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source

