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Structural features affecting variant surface glycoprotein expression in Trypanosoma brucei
Molecular and Biochemical Parasitology, 2003The glycosylphosphatidylinositol (GPI)-anchored variant surface glycoprotein (VSG) of Trypanosoma brucei is the most abundant GPI-anchored protein expressed on any cell, and is an essential virulence factor. To determine what structural features affect efficient expression of VSG, we made a series of mutations in two VSGs.
Jun, Wang +2 more
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Structure and variationwithin variant surface glycoproteins of Trypanosoma brucei
Annales de l'Institut Pasteur / Immunologie, 1985Variant surface glycoproteins of the African trypanosomes are members of a multigene family which show extraordinary amino sequence diversity. The extent of this diversity and the significance of homologies both in the amino acid sequence and in the post-translational modifications are discussed in the light of what is predicted for the structure of ...
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Trypanosoma brucei:Generation of Specific Antisera to Recombinant Variant Surface Glycoproteins
Experimental Parasitology, 1999Abstract Hoek, M., Xu, H., and Cross, G. A. M. 1999.Trypanosoma brucei:Generation of specific antisera to recombinant variant surface glycoproteins.Experimental Parasitology91, 199–202.
M, Hoek, H, Xu, G A, Cross
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Trypanosoma brucei: Frequent loss of a telomeric variant surface glycoprotein gene
Experimental Parasitology, 1989We have observed the loss of an inactive telomeric variant surface glycoprotein (VSG) gene that is located on a minichromosome in Trypanosoma brucei. If this is due to gene conversion, it is the third "silent" gene conversion (i.e., one that does not produce an antigenic switch) detected in 19 antigenic switches of the IsTaR 1 serodeme.
R F, Aline, P J, Myler, K D, Stuart
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Amino terminal sequence homology among variant surface glycoproteins of African trypanosomes
Molecular and Biochemical Parasitology, 1984Amino terminal amino acid sequences were determined for eight variable surface glycoproteins purified from successive parasitemias of cloned Trypanosoma brucei. These sequences were compared by sequence alignment analysis with each other and with amino terminal sequences of variable surface glycoproteins from other clones of T. brucei, T.
R W, Olafson +5 more
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Biochemistry of the Variant Surface Glycoproteins of Salivarian Trypanosomes
1982Publisher Summary This chapter describes the progress made over the past years in characterizing antigens of the principal pathogenic salivarian trypanosomes. Although bulk of information comes from work on the variant antigens of T. b. brucei in particular, much interesting work has been done on the variant antigens of other species and is discussed
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Preferential activation of telomeric variant surface glycoprotein genes in Trypanosoma brucei
Molecular and Biochemical Parasitology, 1985During an infection, Trypanosoma brucei expresses diverse variant surface glycoprotein (VSG) genes in a quasi-sequential order. Numerous VSG genes have intrachromosomal locations but many are located adjacent to telomeres. We have tested whether telomeric VSG genes are preferentially activated compared to intrachromosomal VSG genes during an antigenic ...
R F, Aline +4 more
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Purification of the membrane-form variant surface glycoprotein of Trypanosoma brucei
Journal of Chromatography A, 1990The membrane-form variant surface glycoprotein (mfVSG) is anchored in the plasma membrane of African trypanosomes by a diacylglycerol residue. On cell rupture the anchor is rapidly cleaved by an endogenous phospholipase C. A purification procedure is described which results in native mfVSG devoid of lipase activity.
D, Schell, P, Overath
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Expression of a minichromosomal variant surface glycoprotein gene in Trypanosoma brucei
Nature, 1985African trypanosomes contain numerous variant surface glycoprotein (VSG) genes, but express only one at a time. When different VSG genes are activated by gene duplicative or non-duplicative mechanisms, antigenic variation occurs. Although transcriptionally inactive VSG genes can have either an intra-chromosomal or a telomeric location, all expressed ...
V, Rothwell +4 more
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Rapid evolution of genes coding for variant surface glycoproteins in trypanosomes
Gene, 1982We have used cloned DNA complementary to the messenger RNAs (mRNAs) for different variant surface glycoproteins (VSGs) of Trypanosoma brucei, stock 427, to study the degree of conservation of the corresponding nuclear genes in related trypanosome stocks.
A C, Frasch, P, Borst, J, Van den Burg
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