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Degradation, Recycling, and Shedding of Trypanosoma brucei Variant Surface Glycoprotein
The Journal of Protozoology, 1990ABSTRACT. Trypanosoma brucei bloodstream forms express a densely packed surface coat consisting of identical variant surface glycoprotein (VSG) molecules. This surface coat is subject to antigenic variation by sequential expression of different VSG genes and thus enables the cells to escape the mammalian host's specific immune response.
A, Seyfang, D, Mecke, M, Duszenko
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A structural motif in the variant surface glycoproteins of Trypanosoma brucei
Nature, 1993The variable domain of the trypanosome variant surface glycoprotein (VSG) ILTat 1.24 has been shown by X-ray crystallography to resemble closely the structures of VSG MITat 1.2, despite their low sequence similarity. Specific structural features of these VSGs, including substitution of carbohydrate for an alpha-helix, can be found in other VSG ...
M L, Blum +5 more
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Experimental Parasitology, 1999
Most surface glycoproteins expressed by mammalian-stage forms of Trypanosoma cruzi are homologous to the parasite's trans-sialidase and therefore are members of the parasite's trans-sialidase superfamily. Few members of this superfamily have trans-sialidase activity. The SA85-1 family is a subfamily of the trans-sialidase superfamily whose members lack
S J, Kahn +5 more
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Most surface glycoproteins expressed by mammalian-stage forms of Trypanosoma cruzi are homologous to the parasite's trans-sialidase and therefore are members of the parasite's trans-sialidase superfamily. Few members of this superfamily have trans-sialidase activity. The SA85-1 family is a subfamily of the trans-sialidase superfamily whose members lack
S J, Kahn +5 more
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Experimental Parasitology, 1989
We have previously postulated that telomeric variant surface glycoprotein (VSG) genes in Trypanosoma brucei serve more frequently than intrachromosomal VSG genes as basic copies for gene conversion. To examine this further we determined the sequence for approximately 1200 nucleotides 3' to the telomeric IsTat 1 VSG gene, expressed in early variant ...
R F, Aline, K, Stuart
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We have previously postulated that telomeric variant surface glycoprotein (VSG) genes in Trypanosoma brucei serve more frequently than intrachromosomal VSG genes as basic copies for gene conversion. To examine this further we determined the sequence for approximately 1200 nucleotides 3' to the telomeric IsTat 1 VSG gene, expressed in early variant ...
R F, Aline, K, Stuart
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Journal of Ultrastructure and Molecular Structure Research, 1988
Trypanosoma congolense bloodstream forms were examined for binding sites of polyclonal anti-variant surface glycoprotein (VSG) antibodies using immunoelectron microscopy. Besides the surface, the antibodies labeled intracellular vesicles, the tubular membrane system, secondary lysosomes, and the digestive vacuole. Protein A gold (PAG), peroxidase gold (
U, Frevert, E, Reinwald
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Trypanosoma congolense bloodstream forms were examined for binding sites of polyclonal anti-variant surface glycoprotein (VSG) antibodies using immunoelectron microscopy. Besides the surface, the antibodies labeled intracellular vesicles, the tubular membrane system, secondary lysosomes, and the digestive vacuole. Protein A gold (PAG), peroxidase gold (
U, Frevert, E, Reinwald
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SARS-CoV-2 variant biology: immune escape, transmission and fitness
Nature Reviews Microbiology, 2023Alessandro Maria Carabelli +2 more
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SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies
Nature Reviews Microbiology, 2022, William T Harvey, Joseph Hughes
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Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization
Nature, 2021Delphine Planas +2 more
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Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa
Nature, 2022Sikhulile Moyo +2 more
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Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2
Nature, 2021Lihong Liu, Sho Iketani, Yi-Cheng Guo
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