Characterization of Two Historic Smallpox Specimens from a Czech Museum
Viruses, 2017 Although smallpox has been known for centuries, the oldest available variola virus strains were isolated in the early 1940s. At that time, large regions of the world were already smallpox-free.
Petr Pajer +22 more
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Monkeypox Goes North: Ongoing Worldwide Monkeypox Infections in Humans
Viruses, 2022 In the late 1970s, global vaccination programs resulted in the eradication of smallpox. The Monkeypox virus (MPXV), which is closely related to the smallpox-inducing variola virus, was previously endemic only in Sub-Saharan Africa but is currently ...
Barbara S. Schnierle
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Identification of SNPs associated with variola virus virulence. [PDF]
BioData Min, 2013 Abstract Background Decades after the eradication of smallpox, its etiological agent, variola virus (VARV), remains a threat as a potential bioweapon. Outbreaks of smallpox around the time of the global eradication effort exhibited variable case fatality rates (CFRs), likely attributable in part to complex viral ...
Hoen AG, Gardner SN, Moore JH.
europepmc +5 more sources
Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]
, 2005 Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Bartlett, Nathan W +8 more
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Zhongguo gonggong weisheng, 2023 ObjectiveTo examine status quo and development trends of research worldwide on highly pathogenic pathogens. MethodsIn this study, highly pathogenic pathogens refered to 29 pathogens classified as pathogens of first category in the List of Human ...
Luona LI, Kunlan ZUO, Lili MA, Huan LIU
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Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode [PDF]
, 2016 Item does not contain ...
Atkinson, John P +14 more
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Use of the Aerosol Rabbitpox Virus Model for Evaluation of Anti-Poxvirus Agents
Viruses, 2010 Smallpox is an acute disease caused by infection with variola virus that has had historic effects on the human population due to its virulence and infectivity.
Thomas G. Voss, Chad J. Roy
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The role of research in viral disease eradication and elimination programs: Lessons for malaria eradication [PDF]
, 2011 By examining the role research has played in eradication or regional elimination initiatives for three viral diseases-smallpox, poliomyelitis, and measles-we derive nine cross-cutting lessons applicable to malaria eradication.
Breman, JG +6 more
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The Mpox, serious menace, or paper tiger?
Iranian Journal of Microbiology, 2022 One of the most horrible diseases in history, Smallpox is caused by the Variola from Poxvirus family, has caused great morbidity and mortality along the way since it was eradicated in the 20th century.
Shahram Jalilian, Mohammad-Navid Bastani
doaj +1 more source
What was the primary mode of smallpox transmission? Implications for biodefense [PDF]
, 2012 The mode of infection transmission has profound implications for effective containment by public health interventions. The mode of smallpox transmission was never conclusively established.
Milton, Donald Kirby
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