Results 71 to 80 of about 1,665,482 (247)

Four-gene-combination DNA vaccine protects mice against a lethal vaccinia virus challenge and elicits appropriate antibody responses in nonhuman primates [PDF]

, 2003
Two major infectious forms of vaccinia virus (VACV) have been described: the intracellular mature virion (IMV), and the extracellular enveloped virion (EEV).
J.W Hooper, D.M Custer, E Thompson, Betakova, Blasco, Blasco, Boulter, Chertov, Czerny, Czerny, Demkowicz, Duncan, Eisenbraun, Engelstad, Franke, Galmiche, Goebel, Gordon, Hirt, Hooper, Hooper, Hsiao, Ichihashi, Isaacs, Lai, Law, Massung, McClain, McClain, McConnell, Moss, Niles, O’Connell, Parkinson, Payne, Pertmer, Ramirez, Rodriguez, Roper, Salmons, Schmaljohn, Senkevich, Shchelkunov, Shida, Takahashi, van Eijl, Wallengren, Wolffe, Yeh, Zhang   +49 more
core   +1 more source

Genome-wide comparison of cowpox viruses reveals a new clade related to Variola virus. [PDF]

PLoS One, 2013
Zoonotic infections caused by several orthopoxviruses (OPV) like monkeypox virus or vaccinia virus have a significant impact on human health. In Europe, the number of diagnosed infections with cowpox viruses (CPXV) is increasing in animals as well as in ...
Dabrowski PW, Radonić A, Kurth A, Nitsche A.   +3 more
europepmc   +2 more sources

Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Advanced Science, EarlyView.
The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su, Guoqing Wu, Muya Xiong, Yuhang Wang, Junyuan Cao, Mengyuan You, Yingchun Xiang, Tianqing Nie, Minjun Li, Gengfu Xiao, Leike Zhang, Qiang Shao, Yechun Xu   +12 more
wiley   +1 more source

Bioterrorism [PDF]

, 2006
Terrorism preparedness is a highly specific component of general emergency preparedness. In addition to the unique pediatric issues involved in general emergency preparedness, terrorism preparedness must consider several additional issues, including the ...
Markenson, David, Redlener, Irwin E.
core   +2 more sources

Graphene Oxide‐Based Gene Modulation in Preferential Elimination of Lung Cancer Cells in a 3D Tumor Microenvironment Model

Advanced NanoBiomed Research, EarlyView.
Chemically modified graphene oxide nanocarriers provide a targeted lung cancer gene therapy platform. In a 3D tumor microenvironment model, these nanocarriers deliver therapeutic genes, regulate immune markers, and induce apoptosis in cancer cells. Combined gene delivery enhances cancer cell elimination, demonstrating the potential of this approach for
Francesca Grilli, Sadman Sakib, Fabio Variola, Shan Zou   +3 more
wiley   +1 more source

Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods.

PLoS Pathogens
Smallpox was the most rampant infectious disease killer of the 20th century, yet much remains unknown about the pathogenesis of the variola virus.
Todd M Bell, Paul Facemire, Jeremy J Bearss, Jo Lynne Raymond, Jennifer Chapman, Xiankun Zeng, Joshua D Shamblin, Janice A Williams, Douglas W Grosenbach, Dennis E Hruby, Inger K Damon, Arthur J Goff, Eric M Mucker   +12 more
doaj   +1 more source

Smallpox, Monkeypox and Other Human Orthopoxvirus Infections

Viruses, 2022
Considering that vaccination against smallpox with live vaccinia virus led to serious adverse effects in some cases, the WHO, after declaration of the global eradication of smallpox in 1980, strongly recommended to discontinue the vaccination in all ...
Galina A. Shchelkunova, Sergei N. Shchelkunov   +1 more
doaj   +1 more source

Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors. [PDF]

, 2009
Protein kinase PKR (also known as EIF2AK2) is activated during viral infection and phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF2), leading to inhibition of translation and viral replication. We report fast evolution
Dever, Thomas E, Dittmar, Katharina, Gibbs, James S, Rothenburg, Stefan, Seo, Eun Joo   +4 more
core  

Populations Addressed in Vaccines Approved via the European Medicines Agency

Clinical Pharmacology &Therapeutics, EarlyView.
Therapeutic and prophylactic agents require robust evidence before patient use. Randomized controlled trials are essential for evaluating safety and efficacy but often exclude specific populations that are also targets for the intervention. This study assessed which populations are included in vaccine registration studies and/or addressed in label ...
Débora D. Gräf, Lukas Westphal, Jonathan Kimmelman, Christine E. Hallgreen   +3 more
wiley   +1 more source

That Wonderful Year: Smallpox, Genetic Engineering, and Bio-terrorism [PDF]

, 2003
The thesis of this Article is that the United States, Russia, and by extension, the world as a whole, are pursuing a fundamentally sound strategy in retaining, rather than destroying, the last known remaining samples of the variola virus.
Koplow, David A.
core   +1 more source