Results 81 to 90 of about 12,414 (226)
Journal of Microscopy, EarlyView.Abstract In this short and popular review, we summarise some of our findings analysing the replication cycles of large DNA viruses using scanning transmission electron tomography (STEM tomography) that we applied in the laboratory of Paul Walther. It is also a tribute to a very kind and expert scientist, who recently retired.
Susanne Wieczorek +1 more
wiley +1 more source
Risk Analysis, EarlyView.Abstract There are two separate conceptualizations for assessing existential risks: Planetary Boundaries (PBs) and global catastrophic risks (GCRs). While these concepts are similar in principle, their underpinning literatures tend not to engage with each other.
Eoin McLaughlin, Matthias Beck
wiley +1 more source
Vaccinia protein C16 blocks innate immune sensing of DNA by binding the Ku complex [PDF]
, 2011 VACV gene C16L encodes a 37-kDa protein that is highly conserved in orthopoxviruses and functions as an immunomodulator. Intranasal infection of mice with a virus lacking C16L (vΔC16) induced less weight loss, fewer signs of illness and increased ...
Peters, Nicholas Edward +1 more
core +1 more source
Risk, Hazards &Crisis in Public Policy, Volume 16, Issue 3, September 2025.Abstract This study aims to identify different frontline emergency response workforce's perceived knowledge of hazards and their willingness and motivations to go to work during them. An online version of the “Fight or Flight” survey was distributed and collected from Norwegian emergency personnel during the spring of 2023.
Jarle L. Sørensen +9 more
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2022 Poxviruses are a large and complex family of viruses with members such as monkeypox virus and variola virus. The possibility of an outbreak of monkeypox virus (or a related poxvirus) or the misuse of variola virus justifies the development of ...
Eric M. Mucker +3 more
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Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease
Advanced Science, Volume 12, Issue 26, July 10, 2025.The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su +12 more
wiley +1 more source
Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity [PDF]
, 2013 Virus infection of mammalian cells is sensed by pattern recognition receptors and leads to an innate immune response that restricts virus replication and induces adaptive immunity.
Benfield, C T O +6 more
core +1 more source
Thermo-Efficient Strains of Variola Major Virus
Journal of General Virology, 1967 Thermo-efficient and thermo-sensitive mutants of pox viruses are obtained, without the aid of mutagens, only with difficulty. Kirn and his colleagues (1, 2) have described both a thermo-sensitive and a thermo-efficient mutant of vaccinia virus. This note reports the derivation and properties of two thermo-efficient strains of variola major virus.
H. S. Bedson +2 more
openaire +3 more sources
Replication of Variola Virus in Suspended Cultures of Mammalian Cells [PDF]
Applied Microbiology, 1961 The studies reported here describe the successful propagation of variola virus in spinner cultures of mammalian cells, and the factors which influence its growth. Five established cell lines were used for the propagation of variola virus in a spinner culture system.
Leonard A. Mika, James B. Pirsch
openaire +3 more sources
Advanced NanoBiomed Research, Volume 5, Issue 7, July 2025.Chemically modified graphene oxide nanocarriers provide a targeted lung cancer gene therapy platform. In a 3D tumor microenvironment model, these nanocarriers deliver therapeutic genes, regulate immune markers, and induce apoptosis in cancer cells. Combined gene delivery enhances cancer cell elimination, demonstrating the potential of this approach for
Francesca Grilli +3 more
wiley +1 more source