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Considerations on the Development of Therapeutics in Vascular Calcification [PDF]

Journal of Cardiovascular Development and Disease
Cardiovascular disease is the leading cause of death worldwide. Vascular calcification, the deposition of calcium phosphate mineral in the arterial wall, is the most significant predictor of morbidity and mortality.
Ana M. Valentin Cabrera, Sophie K. Ashbrook, Joshua D. Hutcheson   +2 more
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Epidemiological Research Advances in Vascular Calcification in Diabetes

Journal of Diabetes Research, 2021
Vascular calcification is the transformation of arterial wall mesenchymal cells, particularly smooth muscle cells (SMCs), into osteoblast phenotypes by various pathological factors.
Haipeng Yao, Zhen Sun, Guangyao Zang, Lili Zhang, Lina Hou, Chen Shao, Zhongqun Wang   +6 more
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Sinomenine attenuates uremia vascular calcification by miR-143-5p [PDF]

Scientific Reports
Vascular calcification is considered to be a killer of the cardiovascular system, involved inflammation and immunity. There is no approved therapeutic strategy for the prevention of vascular calcification.
Fengyi Yu, Zhong Peng, Ning Gao, Zixu Tang, Zihao Liao, Song Zhao, Shuzhu Zhong, Gloria Umwiza, Hong Huang, Wei Long, Zhangxiu He   +10 more
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Clinicopathological Features of Anticancer Drug-induced Kidney Injury [PDF]

Zhongguo quanke yixue, 2022
Background The prevalence of anticancer drug-induced kidney injury is increasing, but related renal pathology studies are still rare. Objective To analyze the clinicopathological characteristics of patients with anticancer drug-related kidney injury ...
GENG Tonghui, LI Han, JIN Jingjing, CHENG Meijuan, ZHANG Shenglei, BAI Yaling, XU Jinsheng
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NEXN protects against vascular calcification by promoting SERCA2 SUMOylation and stabilization [PDF]

Nature Communications
Vascular calcification, a key risk factor for cardiovascular diseases, is driven by the phenotypic transition of vascular smooth muscle cells from a contractile to an osteogenic phenotype.
Wenjie Guo, Wenjing Guo, Boliang Chen, Zexuan Lin, Zhuohua Wen, Jiamin Ye, Wei Feng, Xin Feng, Jianyun Yan, Pingzhen Yang, Kunfu Ouyang, Yifei Li, Hanyan Yang, Caiwen Ou, Canzhao Liu   +14 more
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Effect of cardiac function in patients with gastrointestinal cancer with or without acute kidney injury assessed using a non-invasive impedance cardiography: a case-control study

BMC Cardiovascular Disorders, 2023
Objectives This study aimed to analyze the possible causes of changes in cardiac function and investigate the feasibility of clinical assessment of gastrointestinal cancer in patients with or without acute kidney injury (AKI) assessed using a non ...
Huihui Chen, Guolei Zhang, Lei He, Wei Zhou, Shenglei Zhang, Zhe zhe Niu, Jingjing Jin, Mei juan Cheng, Liping Guo, Xiang nan Liang, Rong fang Zhu, Huiran Zhang, Yaling Bai, Jin sheng Xu   +13 more
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Correlation between serum level of PARP1 and vascular calcification in hemodialysis patients

Linchuang shenzangbing zazhi, 2023
Objective To explore the correlation between serum level of poly(ADP-ribose) polymerase 1 (PARP1) and vascular calcification in hemodialysis (HD) patients.
Hui Zhang, Jin-hui Luo, Liu Yang, Yun-tao Tong, Hong-lin Cai   +4 more
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Pathophysiology and Clinical Impacts of Chronic Kidney Disease on Coronary Artery Calcification

Journal of Cardiovascular Development and Disease, 2023
The global prevalence of chronic kidney disease (CKD) has increased in recent years. Adverse cardiovascular events have become the main cause of life-threatening events in patients with CKD, and vascular calcification is a risk factor for cardiovascular ...
Zhuoming Dai, Xiangyu Zhang
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The Contribution of Extracellular Vesicles From Senescent Endothelial and Vascular Smooth Muscle Cells to Vascular Calcification

Frontiers in Cardiovascular Medicine, 2022
Vascular calcification is an irreversible pathological process associated with a loss of vascular wall function. This process occurs as a result of aging and age-related diseases, such as cardiovascular and chronic kidney diseases, and leads to ...
Cristina Mas-Bargues, Cristina Mas-Bargues, Cristina Mas-Bargues, Consuelo Borrás, Consuelo Borrás, Consuelo Borrás, Matilde Alique, Matilde Alique   +7 more
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Deletion of soluble epoxide hydrolase suppressed chronic kidney disease-related vascular calcification by restoring Sirtuin 3 expression

Cell Death and Disease, 2021
Vascular calcification is common in chronic kidney disease (CKD) and contributes to cardiovascular disease (CVD) without any effective therapies available up to date.
Wanbing He, Jieping Huang, Yang Liu, Changming Xie, Kun Zhang, Xinhong Zhu, Jie Chen, Hui Huang   +7 more
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