Results 21 to 30 of about 1,474,592 (383)

Vascular Calcification: Key Roles of Phosphate and Pyrophosphate

International Journal of Molecular Sciences, 2021
Cardiovascular complications due to accelerated arterial stiffening and atherosclerosis are the leading cause of morbimortality in Western society. Both pathologies are frequently associated with vascular calcification.
R. Villa-Bellosta
semanticscholar   +1 more source

Pathophysiology and Clinical Impacts of Chronic Kidney Disease on Coronary Artery Calcification

Journal of Cardiovascular Development and Disease, 2023
The global prevalence of chronic kidney disease (CKD) has increased in recent years. Adverse cardiovascular events have become the main cause of life-threatening events in patients with CKD, and vascular calcification is a risk factor for cardiovascular ...
Zhuoming Dai, Xiangyu Zhang
doaj   +1 more source

Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway

Aging Cell, 2021
Vascular calcification is a common pathologic condition in patients with chronic kidney disease (CKD) and aging individuals. It has been established that vascular calcification is a gene‐regulated biological process resembling osteogenesis involving ...
Xiaoyu Liu, An Chen, Qingchun Liang, Xiulin Yang, Qianqian Dong, M. Fu, Siyi Wang, Yining Li, Yuanzhi Ye, Zirong Lan, Yantin Chen, J. Ou, Pingzhen Yang, Lihe Lu, Jianyun Yan   +14 more
semanticscholar   +1 more source

The Contribution of Extracellular Vesicles From Senescent Endothelial and Vascular Smooth Muscle Cells to Vascular Calcification

Frontiers in Cardiovascular Medicine, 2022
Vascular calcification is an irreversible pathological process associated with a loss of vascular wall function. This process occurs as a result of aging and age-related diseases, such as cardiovascular and chronic kidney diseases, and leads to ...
Cristina Mas-Bargues, Cristina Mas-Bargues, Cristina Mas-Bargues, Consuelo Borrás, Consuelo Borrás, Consuelo Borrás, Matilde Alique, Matilde Alique   +7 more
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Mitochondrial Dysfunction: Cause or Consequence of Vascular Calcification?

Frontiers in Cell and Developmental Biology, 2021
Mitochondria are crucial bioenergetics powerhouses and biosynthetic hubs within cells, which can generate and sequester toxic reactive oxygen species (ROS) in response to oxidative stress.
Kanchan Phadwal, Christina Vrahnas, I. Ganley, V. Macrae   +3 more
semanticscholar   +1 more source

Mechanisms of Vascular Calcification [PDF]

Advances in Chronic Kidney Disease, 2007
Vascular calcification is highly prevalent and correlated with high rates of cardiovascular mortality in chronic kidney disease patients. Recent evidence suggests that mineral, hormonal, and metabolic imbalances that promote phenotype change in vascular cells as well as deficiencies in specific mineralization inhibitory pathways may be important ...
Mohga El‐Abbadi, Cecilia M. Giachelli
openalex   +4 more sources

Contributions of the Endothelium to Vascular Calcification [PDF]

Frontiers in Cell and Developmental Biology, 2021
Vascular calcification (VC) increases morbidity and mortality and constitutes a significant obstacle during percutaneous interventions and surgeries. On a cellular and molecular level, VC is a highly regulated process that involves abnormal cell transitions and osteogenic differentiation, re-purposing of signaling pathways normally used in bone, and ...
Li Zhang, Jiayi Yao, Yucheng Yao, Yucheng Yao, Kristina I. Boström, Kristina I. Boström   +5 more
openaire   +6 more sources

Vascular Calcification—New Insights into Its Mechanism

International Journal of Molecular Sciences, 2020
Vascular calcification (VC), which is categorized by intimal and medial calcification, depending on the site(s) involved within the vessel, is closely related to cardiovascular disease.
S. Lee, In-kyu Lee, Jae-Han Jeon
semanticscholar   +1 more source

Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress, and extracellular vesicle release in vascular smooth muscle cells

Cardiovascular Research, 2021
Aims Smokers are at increased risk of cardiovascular events. However, the exact mechanisms through which smoking influences cardiovascular disease resulting in accelerated atherosclerosis and vascular calcification are unknown.
Ploingarm Petsophonsakul, M. Burgmaier, Brecht A. G. Willems, S. Heeneman, Nadina Stadler, F. Gremse, S. Reith, K. Burgmaier, F. Kahles, N. Marx, E. Natour, E. Bidar, M. Jacobs, B. Mees, C. Reutelingsperger, M. Furmanik, L. Schurgers   +16 more
semanticscholar   +1 more source

Deletion of soluble epoxide hydrolase suppressed chronic kidney disease-related vascular calcification by restoring Sirtuin 3 expression

Cell Death and Disease, 2021
Vascular calcification is common in chronic kidney disease (CKD) and contributes to cardiovascular disease (CVD) without any effective therapies available up to date.
Wanbing He, Jieping Huang, Yang Liu, Changming Xie, Kun Zhang, Xinhong Zhu, Jie Chen, Hui Huang   +7 more
doaj   +1 more source