Results 21 to 30 of about 1,468,943 (359)

Vascular calcification [PDF]

Journal of Renal Care, 2009
Patients with chronic kidney disease have increased cardiovascular mortality from a combination of increased atherosclerotic disease, left ventricular hypertrophy and increased prevalence of vascular calcification (VC). Previously VC was thought to be a passive process which involved the deposition of calcium and phosphate into the vessel wall. However,
Sinha, Smeeta, Eddington, Helen, Kalra, Philip A.   +2 more
openaire   +2 more sources

Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress, and extracellular vesicle release in vascular smooth muscle cells

Cardiovascular Research, 2021
Aims Smokers are at increased risk of cardiovascular events. However, the exact mechanisms through which smoking influences cardiovascular disease resulting in accelerated atherosclerosis and vascular calcification are unknown.
Ploingarm Petsophonsakul, M. Burgmaier, Brecht A. G. Willems, S. Heeneman, Nadina Stadler, F. Gremse, S. Reith, K. Burgmaier, F. Kahles, N. Marx, E. Natour, E. Bidar, M. Jacobs, B. Mees, C. Reutelingsperger, M. Furmanik, L. Schurgers   +16 more
semanticscholar   +1 more source

Vascular Calcification [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2011
More than a century ago, Monckeberg1 was among the first to note that ectopic calcification may arise in the vasculature. Although this original description was of a specific form of sclerosing calcification that largely affects the vascular medial layer, we have since gone on to appreciate that generalized vascular calcification is a pervasive and ...
Jason C, Kovacic, Gwendalyn J, Randolph
openaire   +5 more sources

Mitochondrial Dysfunction: Cause or Consequence of Vascular Calcification?

Frontiers in Cell and Developmental Biology, 2021
Mitochondria are crucial bioenergetics powerhouses and biosynthetic hubs within cells, which can generate and sequester toxic reactive oxygen species (ROS) in response to oxidative stress.
Kanchan Phadwal, Christina Vrahnas, I. Ganley, V. Macrae   +3 more
semanticscholar   +1 more source

Unspliced XBP1 Counteracts β-Catenin to Inhibit Vascular Calcification

Circulation Research, 2021
Supplemental Digital Content is available in the text. Background: Vascular calcification is a prevalent complication in chronic kidney disease and contributes to increased cardiovascular morbidity and mortality.
Liu Yang, Rongbo Dai, Hao Wu, Z. Cai, Nan Xie, Xu Zhang, Yicong Shen, Ze Gong, Yiting Jia, F. Yu, Ying Zhao, Pinglan Lin, Chaoyang Ye, Yanhua Hu, Yi Fu, Qingbo Xu, Zhiqing Li, W. Kong   +17 more
semanticscholar   +1 more source

ERK1/2 inhibition reduces vascular calcification by activating miR-126-3p-DKK1/LRP6 pathway

Theranostics, 2021
Rationale: Vascular microcalcification increases the risk of rupture of vulnerable atherosclerotic lesions. Inhibition of ERK1/2 reduces atherosclerosis in animal models while its role in vascular calcification and the underlying mechanisms remains ...
Peng Zeng, Jie Yang, Lipei Liu, Xiaoxiao Yang, Z. Yao, Chuanrui Ma, Haibo Zhu, Jiamin Su, Qian Zhao, Ke Feng, Shu Yang, Yan Zhu, Xiaoju Li, Wenguang Wang, Yajun Duan, Jihong Han, Yuanli Chen   +16 more
semanticscholar   +1 more source

Vascular Calcification—New Insights into Its Mechanism

International Journal of Molecular Sciences, 2020
Vascular calcification (VC), which is categorized by intimal and medial calcification, depending on the site(s) involved within the vessel, is closely related to cardiovascular disease.
S. Lee, In-kyu Lee, Jae-Han Jeon
semanticscholar   +1 more source

Deletion of soluble epoxide hydrolase suppressed chronic kidney disease-related vascular calcification by restoring Sirtuin 3 expression

Cell Death and Disease, 2021
Vascular calcification is common in chronic kidney disease (CKD) and contributes to cardiovascular disease (CVD) without any effective therapies available up to date.
Wanbing He, Jieping Huang, Yang Liu, Changming Xie, Kun Zhang, Xinhong Zhu, Jie Chen, Hui Huang   +7 more
doaj   +1 more source

The Role of AIF-1 in the Aldosterone-Induced Vascular Calcification Related to Chronic Kidney Disease: Evidence From Mice Model and Cell Co-Culture Model

Frontiers in Endocrinology, 2022
Increasing evidence suggests that aldosterone (Aldo) plays an essential role in vascular calcification which is a serious threat to cardiovascular disease (CVD) developed from chronic kidney disease (CKD).
Xueying Chang, Jianbing Hao, Xingzhi Wang, Jingwei Liu, Jie Ni, Lirong Hao   +5 more
doaj   +1 more source

Sclerostin Protects Against Vascular Calcification Development in Mice

Journal of Bone and Mineral Research, 2021
Sclerostin is a negative regulator of the Wnt/β‐catenin signaling and is, therefore, an important inhibitor of bone formation and turnover. Because ectopic vascular calcification develops in a similar way to bone formation, one might reasonably attribute
Annelies De Maré, Britt Opdebeeck, E. Neven, P. D’Haese, A. Verhulst   +4 more
semanticscholar   +1 more source