Results 31 to 40 of about 1,474,592 (383)

The Role of AIF-1 in the Aldosterone-Induced Vascular Calcification Related to Chronic Kidney Disease: Evidence From Mice Model and Cell Co-Culture Model

Frontiers in Endocrinology, 2022
Increasing evidence suggests that aldosterone (Aldo) plays an essential role in vascular calcification which is a serious threat to cardiovascular disease (CVD) developed from chronic kidney disease (CKD).
Xueying Chang, Jianbing Hao, Xingzhi Wang, Jingwei Liu, Jie Ni, Lirong Hao   +5 more
doaj   +1 more source

ERK1/2 inhibition reduces vascular calcification by activating miR-126-3p-DKK1/LRP6 pathway

Theranostics, 2021
Rationale: Vascular microcalcification increases the risk of rupture of vulnerable atherosclerotic lesions. Inhibition of ERK1/2 reduces atherosclerosis in animal models while its role in vascular calcification and the underlying mechanisms remains ...
Peng Zeng, Jie Yang, Lipei Liu, Xiaoxiao Yang, Z. Yao, Chuanrui Ma, Haibo Zhu, Jiamin Su, Qian Zhao, Ke Feng, Shu Yang, Yan Zhu, Xiaoju Li, Wenguang Wang, Yajun Duan, Jihong Han, Yuanli Chen   +16 more
semanticscholar   +1 more source

Gla-rich protein (GRP) as an early and novel marker of vascular calcification and kidney dysfunction in diabetic patients with CKD: a pilot cross-sectional study [PDF]

, 2020
Vascular calcification (VC) is one of the strongest predictors of cardiovascular risk in chronic kidney disease (CKD) patients. New diagnostic/prognostic tools are required for early detection of VC allowing interventional strategies.
Almeida, Edgar de, Dias, Carolina, Faísca, Marília, Guilherme, Patrícia, Macedo, Ana, Mendes, Filipa, Neves, Pedro Leão, Rato, Fátima, Santos, Nélio, Silva, Ana P., Simes, Dina, Tavares, Nelson, Viegas, Carla   +12 more
core   +1 more source

Sclerostin Protects Against Vascular Calcification Development in Mice

Journal of Bone and Mineral Research, 2021
Sclerostin is a negative regulator of the Wnt/β‐catenin signaling and is, therefore, an important inhibitor of bone formation and turnover. Because ectopic vascular calcification develops in a similar way to bone formation, one might reasonably attribute
Annelies De Maré, Britt Opdebeeck, E. Neven, P. D’Haese, A. Verhulst   +4 more
semanticscholar   +1 more source

Aortic calcification and femoral bone density are independently associated with left ventricular mass in patients with chronic kidney disease [PDF]

, 2012
Background Vascular calcification and reduced bone density are prevalent in chronic kidney disease and linked to increased cardiovascular risk. The mechanism is unknown.
Chue, Colin D., Crabtree, Nicola J., Edwards, Nicola C., Ferro, Charles J., Moody, William E., Steeds, Richard P., Townend, Jonathan N., Wall, Nadezhda A., Zehnder, Daniel   +8 more
core   +7 more sources

Cellular Crosstalk in the Vascular Wall Microenvironment: The Role of Exosomes in Vascular Calcification

Frontiers in Cardiovascular Medicine, 2022
Vascular calcification is prevalent in aging, diabetes, chronic kidney disease, cardiovascular disease, and certain genetic disorders. However, the pathogenesis of vascular calcification is not well-understood.
Yun-Yun Wu, Su-Kang Shan, Xiao Lin, Xiao Lin, Feng Xu, Jia-Yu Zhong, Feng Wu, Jia-Yue Duan, Bei Guo, Fu-Xing-Zi Li, Yi Wang, Ming-Hui Zheng, Qiu-Shuang Xu, Li-Min Lei, Wen-Lu Ou-Yang, Ke-Xin Tang, Chang-Chun Li, Muhammad Hasnain Ehsan Ullah, Ling-Qing Yuan   +18 more
doaj   +1 more source

Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals

Arteriosclerosis, Thrombosis and Vascular Biology, 2020
Supplemental Digital Content is available in the text. Objectives: Vascular calcification is highly prevalent in patients with chronic kidney disease. Increased plasma trimethylamine N-oxide (TMAO), a gut microbiota-dependent product, concentrations are ...
Xiuli Zhang, Yining Li, Pingzhen Yang, Xiaoyu Liu, Lihe Lu, Yantin Chen, Xinglong Zhong, Zehua Li, Hailin Liu, Caiwen Ou, Jianyun Yan, Minsheng Chen   +11 more
semanticscholar   +1 more source

Unspliced XBP1 Counteracts β-Catenin to Inhibit Vascular Calcification

Circulation Research, 2021
Supplemental Digital Content is available in the text. Background: Vascular calcification is a prevalent complication in chronic kidney disease and contributes to increased cardiovascular morbidity and mortality.
Liu Yang, Rongbo Dai, Hao Wu, Z. Cai, Nan Xie, Xu Zhang, Yicong Shen, Ze Gong, Yiting Jia, F. Yu, Ying Zhao, Pinglan Lin, Chaoyang Ye, Yanhua Hu, Yi Fu, Qingbo Xu, Zhiqing Li, W. Kong   +17 more
semanticscholar   +1 more source

Molecular mechanisms and effects of urocortin II on rat adventitial fibroblast calcification induced by calcified medium

Vascular Biology, 2022
The present study aimed to assess the role of urocortin II (UII) in the process of vascular calcification in vitro by using a calcification model, to detect the changes in the mRNA and protein levels of associated markers in rat adventitial fibroblasts ...
Xusheng Zhang, Zhanjun Huang, Xiaorong Fan, Xiaoqing Tan, Chengzhi Lu, Jianshe Yang   +5 more
doaj   +1 more source

The galectin-3/RAGE dyad modulates vascular osteogenesis in atherosclerosis [PDF]

, 2013
Vascular calcification correlates with inflammation and plaque instability in a dual manner, depending on the spotty/granular (micro) or sheet-like/lamellated (macro) pattern of calcification.
BLASETTI FANTAUZZI, Claudia, Carlo M., Pesce, Familiari, Giuseppe, Iacobini, Carla, Menini, Stefano, Pugliese, Giuseppe, Relucenti, Michela, Ricci, Carlo, Salvi, Laura, Taurino, Maurizio   +9 more
core   +1 more source