Results 31 to 40 of about 1,499,832 (396)

Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress, and extracellular vesicle release in vascular smooth muscle cells

Cardiovascular Research, 2021
Aims Smokers are at increased risk of cardiovascular events. However, the exact mechanisms through which smoking influences cardiovascular disease resulting in accelerated atherosclerosis and vascular calcification are unknown.
Ploingarm Petsophonsakul, M. Burgmaier, Brecht A. G. Willems, S. Heeneman, Nadina Stadler, F. Gremse, S. Reith, K. Burgmaier, F. Kahles, N. Marx, E. Natour, E. Bidar, M. Jacobs, B. Mees, C. Reutelingsperger, M. Furmanik, L. Schurgers   +16 more
semanticscholar   +1 more source

Contributions of the Endothelium to Vascular Calcification [PDF]

Frontiers in Cell and Developmental Biology, 2021
Vascular calcification (VC) increases morbidity and mortality and constitutes a significant obstacle during percutaneous interventions and surgeries. On a cellular and molecular level, VC is a highly regulated process that involves abnormal cell transitions and osteogenic differentiation, re-purposing of signaling pathways normally used in bone, and ...
Li Zhang, Jiayi Yao, Yucheng Yao, Yucheng Yao, Kristina I. Boström, Kristina I. Boström   +5 more
openaire   +6 more sources

Mitochondrial Dysfunction: Cause or Consequence of Vascular Calcification?

Frontiers in Cell and Developmental Biology, 2021
Mitochondria are crucial bioenergetics powerhouses and biosynthetic hubs within cells, which can generate and sequester toxic reactive oxygen species (ROS) in response to oxidative stress.
Kanchan Phadwal, Christina Vrahnas, I. Ganley, V. Macrae   +3 more
semanticscholar   +1 more source

The Role of AIF-1 in the Aldosterone-Induced Vascular Calcification Related to Chronic Kidney Disease: Evidence From Mice Model and Cell Co-Culture Model

Frontiers in Endocrinology, 2022
Increasing evidence suggests that aldosterone (Aldo) plays an essential role in vascular calcification which is a serious threat to cardiovascular disease (CVD) developed from chronic kidney disease (CKD).
Xueying Chang, Jianbing Hao, Xingzhi Wang, Jingwei Liu, Jie Ni, Lirong Hao   +5 more
doaj   +1 more source

HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype. [PDF]

, 2019
Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine SNPs associated with the extent of abdominal aortic calcification (n = 9,417) or descending ...
Bagchi, Aranya, Barnes, Hanna J, Bloch, Donald B, Bowden, Donald W, Budoff, Matthew, Buswell, Mary D, Buys, Emmanuel S, Campbell, Catherine Y, Criqui, Michael H, Debette, Stephanie, Erbel, Raimund, Feitosa, Mary F, Franceschini, Nora, Freedman, Barry I, Gudnason, Vilmundur, Guo, Xiuqing, Harris, Tamara, Hoffmann, Udo, Hwang, Shih-Jen, Johnson, Andrew D, Jöckel, Karl-Heinz, Kälsch, Hagen, Lindsay, Mark E, Lino Cardenas, Christian L, Lu, Lingyi, Malhotra, Rajeev, Mauer, Andreas C, Moebus, Susanne, Nicholson, Christopher J, Nigwekar, Sagar U, Nöthen, Markus M, O'Donnell, Christopher J, Pechlivanis, Sonali, Post, Wendy S, Rhee, David K, Rotter, Jerome I, Rourke, Caitlin O', Shelton, Georgia, Sigurdsson, Sigurdur, Sigurslid, Haakon H, Slocum, Charles, Smith, Albert V, Song, Ci, Thanassoulis, George, Wang, Judy, Wong, Quenna, Wunderer, Florian, Yao, Jie, Zapol, Warren M, Zhang, Xiaoling   +49 more
core   +1 more source

Sclerostin Protects Against Vascular Calcification Development in Mice

Journal of Bone and Mineral Research, 2021
Sclerostin is a negative regulator of the Wnt/β‐catenin signaling and is, therefore, an important inhibitor of bone formation and turnover. Because ectopic vascular calcification develops in a similar way to bone formation, one might reasonably attribute
Annelies De Maré, Britt Opdebeeck, E. Neven, P. D’Haese, A. Verhulst   +4 more
semanticscholar   +1 more source

ERK1/2 inhibition reduces vascular calcification by activating miR-126-3p-DKK1/LRP6 pathway

Theranostics, 2021
Rationale: Vascular microcalcification increases the risk of rupture of vulnerable atherosclerotic lesions. Inhibition of ERK1/2 reduces atherosclerosis in animal models while its role in vascular calcification and the underlying mechanisms remains ...
Peng Zeng, Jie Yang, Lipei Liu, Xiaoxiao Yang, Z. Yao, Chuanrui Ma, Haibo Zhu, Jiamin Su, Qian Zhao, Ke Feng, Shu Yang, Yan Zhu, Xiaoju Li, Wenguang Wang, Yajun Duan, Jihong Han, Yuanli Chen   +16 more
semanticscholar   +1 more source

Cellular Crosstalk in the Vascular Wall Microenvironment: The Role of Exosomes in Vascular Calcification

Frontiers in Cardiovascular Medicine, 2022
Vascular calcification is prevalent in aging, diabetes, chronic kidney disease, cardiovascular disease, and certain genetic disorders. However, the pathogenesis of vascular calcification is not well-understood.
Yun-Yun Wu, Su-Kang Shan, Xiao Lin, Xiao Lin, Feng Xu, Jia-Yu Zhong, Feng Wu, Jia-Yue Duan, Bei Guo, Fu-Xing-Zi Li, Yi Wang, Ming-Hui Zheng, Qiu-Shuang Xu, Li-Min Lei, Wen-Lu Ou-Yang, Ke-Xin Tang, Chang-Chun Li, Muhammad Hasnain Ehsan Ullah, Ling-Qing Yuan   +18 more
doaj   +1 more source

MicroRNAs Regulate Vascular Medial Calcification [PDF]

, 2014
Vascular calcification is highly prevalent in patients with coronary artery disease and, when present, is associated with major adverse cardiovascular events, including an increased risk of cardiovascular mortality.
Leopold, Jane A.
core   +2 more sources

Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals

Arteriosclerosis, Thrombosis and Vascular Biology, 2020
Supplemental Digital Content is available in the text. Objectives: Vascular calcification is highly prevalent in patients with chronic kidney disease. Increased plasma trimethylamine N-oxide (TMAO), a gut microbiota-dependent product, concentrations are ...
Xiuli Zhang, Yining Li, Pingzhen Yang, Xiaoyu Liu, Lihe Lu, Yantin Chen, Xinglong Zhong, Zehua Li, Hailin Liu, Caiwen Ou, Jianyun Yan, Minsheng Chen   +11 more
semanticscholar   +1 more source