Results 41 to 50 of about 1,468,943 (359)

Molecular mechanisms and effects of urocortin II on rat adventitial fibroblast calcification induced by calcified medium

Vascular Biology, 2022
The present study aimed to assess the role of urocortin II (UII) in the process of vascular calcification in vitro by using a calcification model, to detect the changes in the mRNA and protein levels of associated markers in rat adventitial fibroblasts ...
Xusheng Zhang, Zhanjun Huang, Xiaorong Fan, Xiaoqing Tan, Chengzhi Lu, Jianshe Yang   +5 more
doaj   +1 more source

Vascular calcification: Mechanisms of vascular smooth muscle cell calcification [PDF]

Trends in Cardiovascular Medicine, 2015
Vascular calcification is highly prevalent and, when present, is associated with major adverse cardiovascular events. Vascular smooth muscle cells play an integral role in mediating vessel calcification by undergoing differentiation to osteoblast-like cells and generating matrix vesicles that serve as a nidus for calcium-phosphate deposition in the ...
openaire   +2 more sources

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness

Cardiovascular Research, 2018
Vascular calcification is associated with a significant increase in all-cause mortality and atherosclerotic plaque rupture. Calcification has been determined to be an active process driven in part by vascular smooth muscle cell (VSMC ...
A. Durham, Mei Y. Speer, M. Scatena, C. Giachelli, C. Shanahan   +4 more
semanticscholar   +1 more source

Antihypertensive treatment with hydrochlorothiazide-hydralazine combination aggravates medial vascular calcification in CKD rats with mineral bone disorder

Frontiers in Cardiovascular Medicine, 2023
BackgroundArterial stiffness and medial vascular calcification, leading to isolated systolic blood pressure (BP), are major cardiovascular risk factors in patients with chronic kidney disease (CKD) and mineral bone disorders (MBD).
Richard Larivière, Richard Larivière, Roth-Visal Ung, Sylvain Picard, Darren E. Richard, Darren E. Richard, Fabrice Mac-Way, Fabrice Mac-Way, Mohsen Agharazii, Mohsen Agharazii   +9 more
doaj   +1 more source

Circulating microRNAs and vascular calcification in hemodialysis patients

Journal of International Medical Research, 2019
Objective Vascular calcification is common in chronic dialysis patients and is associated with increased morbidity and mortality. However, the role of circulating microRNAs (miRs) in vascular calcification has rarely been investigated.
Chien-Te Lee, Yueh-Ting Lee, You-Lin Tain, Hwee-Yeong Ng, Wei-Hung Kuo   +4 more
doaj   +1 more source

Impact of vascular calcification on cardiovascular mortality in hemodialysis patients: clinical significance, mechanisms and possible strategies for treatment

Renal Replacement Therapy, 2017
Vascular calcification has now been recognized as a major problem in dialysis patients because of its strong influence on the prognosis. Along with the regulatory failure of calcification-inhibitory system, active phenotypic change of vascular smooth ...
Takayasu Ohtake, Shuzo Kobayashi
doaj   +1 more source

Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4 [PDF]

Endocrinology and Metabolism, 2016
Vascular calcification, abnormal mineralization of the vessel wall, is frequently associated with aging, atherosclerosis, diabetes mellitus, and chronic kidney disease.
Jaechan Leem, In-Kyu Lee
doaj   +1 more source

Influence of FOSL1 Inhibition on Vascular Calcification and ROS Generation through Ferroptosis via P53-SLC7A11 Axis

Biomedicines, 2023
Background: Vascular calcification during aging is highly prevalent in patients with cardiovascular disease; however, there is still no improvement in clarifying the development of vascular calcification.
Sisi Shao, Yaoxin Liu, Wanzi Hong, Yuanxi Mo, Fen Shu, Lei Jiang, Ning Tan   +6 more
doaj   +1 more source

MGP T-138C Polymorphism (TT Genotype) is Associated with Vascular Calcification Incidence in Indonesian Regular Hemodialysis Patients

Indonesian Biomedical Journal, 2020
BACKGROUND: Vascular calcification contributes greatly to the incidence of cardiovascular disease. Previously, vascular calcification was considered as a passive process caused by the mineral deposition from the circulation.
Muhammad Hanif Wibowo, Riri Andri Muzasti, Syafrizal Nasution   +2 more
doaj   +1 more source

Calcification of Synthetic Vascular Grafts: A Systematic Review

EJVES Vascular Forum, 2023
Objective: Calcification of vascular grafts, including polyethylene terephthalate (PET) and expanded polytetrafluoroethylene (ePTFE) grafts may contribute to graft failure, but is under reported.
Anne Lejay, Bogdan Bratu, Salomé Kuntz, Nicole Neumann, Frederic Heim, Nabil Chakfé   +5 more
doaj   +1 more source