Results 21 to 30 of about 935,408 (401)

The biology of vascular endothelial growth factors [PDF]

Cardiovascular Research, 2005
The discovery of the vascular endothelial growth factor (VEGF) family members VEGF, VEGF-B, placental growth factor (PlGF), VEGF-C and VEGF-D and their receptors VEGFR-1, -2 and -3 has provided tools for studying the vascular system in development as well as in diseases ranging from ischemic heart disease to cancer.
Tuomas Tammela, Karri Paavonen, Kari Alitalo, Berndt Enholm   +3 more
openaire   +3 more sources

Streptozotocin induced diabetic retinopathy in rat and the expression of vascular endothelial growth factor and its receptor [PDF]

International Journal of Ophthalmology, 2013
AIM:To establish the rat model of streptozotocin (STZ)-induced diabetic retinopathy (DR), which is the most common cause of visual loss and blindness in patients with diabetes, and observe the gene expression of vascular endothelial growth factor (VEGF ...
Chen-Yuan Gong, Bin Lu, Qian-Wen Hu, Li-Li Ji   +3 more
doaj   +1 more source

Enhanced Vascularization of Cultured Skin Substitutes Genetically Modified to Overexpress Vascular Endothelial Growth Factor11The authors declared in writing to have no conflict of interest. [PDF]

, 2000
Cultured skin substitutes have been used as adjunctive therapies in the treatment of burns and chronic wounds, but they are limited by lack of a vascular plexus.
Supp, Dorothy M., Supp, Andrew P., Boyce, Steven T., Bell, Sheila M.   +3 more
core   +3 more sources

Positive and negative regulation of angiogenesis by soluble vascular endothelial growth factor receptor-1 [PDF]

, 2018
Vascular endothelial growth factor receptor (VEGFR)-1 exists in different forms, derived from alternative splicing of the same gene. In addition to the transmembrane form, endothelial cells produce a soluble VEGFR-1 (sVEGFR-1) isoform, whereas non ...
Carbo, Miriam, Failla, Cristina M., Morea, Veronica   +2 more
core   +2 more sources

In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis [PDF]

, 2014
Methodology: We have utilized a rational in silico-based approach to demonstrate the design and study of a novel compound that acts as a dual inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2) and cyclin-dependent kinase 1 (CDK1).
AM Latham, Antony M. Latham, B Apsel, Colin W. G. Fishwick, D Santamaria, Domenico Ribatti, E Schonbrunn, EA Murphy, G Bergers, G Draetta, Gareth W. Fearnley, GI Evan, GJ Howell, GW Fearnley, H Haddad, H Huynh, I Zachary, J Galon, J Kankanala, J Lee, J Pines, Jayakanth Kankanala, JC Tille, JJ Tung, JM Ebos, JW Schmidberger, K Boda, KM Malinda, M Doree, M Mohammadi, MA Ali, MA Branca, Mark T. Kearney, Matthew C. Gage, MP Jacobson, MS Squires, N Ferrara, O Timofeev, P Carmeliet, P Carmeliet, PA Harris, PG Wyatt, Q Wang, R Morphy, RA Friesner, RA Friesner, S Emanuel, S Huang, S Koch, S Koch, S Ponnambalam, Shervanthi Homer-Vanniasinkam, Sreenivasan Ponnambalam, Stephen B. Wheatcroft, T Anastassiadis, T Bashir, TA Halgren, TA Potapova, V Knights, VE Neubrand, ZW Cai   +60 more
core   +5 more sources

Effects of diabetes on myocardial capillary density and serum angiogenesis biomarkers in male rats

Clinics, 2011
INTRODUCTION: Cardiovascular disease is one of the main causes of mortality and morbidity in diabetic patients. This study evaluated the effects of diabetes on myocardial capillary density and several serum angiogenic factors including nitric oxide ...
Majid Khazaei, Ali Reza Fallahzadeh, Mohammad Reza Sharifi, Noushin Afsharmoghaddam, Shaghayegh Haghjooy Javanmard, Ensieh Salehi   +5 more
doaj   +1 more source

VEGFR2 trafficking, signaling and proteolysis is regulated by the ubiquitin isopeptidase USP8 [PDF]

, 2016
Vascular endothelial growth factor A (VEGF-A) regulates many aspects of vascular function. VEGF-A binding to vascular endothelial growth factor receptor 2 (VEGFR2) stimulates endothelial signal transduction and regulates multiple cellular responses ...
Adhikari, Bruns, Bruns, Clague, Clague, Ewan, Fearnley, Gao, Horowitz, Howell, Hurley, Jopling, Jopling, Kato, Koch, Koch, Lanahan, MacDonald, McCullough, Meijer, Melker, Mizuno, Mizuno, Olsson, Pickart, Row, Sawamiphak, Shibuya, Tanaka, Wing, Zhang   +30 more
core   +1 more source

Vascular endothelial growth factors and vascular permeability [PDF]

Cardiovascular Research, 2010
Vascular endothelial growth factors (VEGFs) are key regulators of permeability. The principal evidence behind how they increase vascular permeability in vivo and in vitro and the consequences of that increase are addressed here. Detailed analysis of the published literature has shown that in vivo and in vitro VEGF-mediated permeability differs in its ...
openaire   +3 more sources

Porcine bone scaffolds adsorb growth factors secreted by MSCs and improve bone tissue repair [PDF]

, 2017
An ideal tissue-engineered bone graft should have both excellent pro-osteogenesis and pro-angiogenesis properties to rapidly realize the bone regeneration in vivo . To meet this goal, in this work a porcine bone scaffold was successfully used as a Trojan
Bressan, Eriberto, Ferroni, Letizia, Gardin, Chiara, Mijiritsky, Eitan, Piattelli, Adriano, Zanette, Gastone, Zavan, Barbara   +6 more
core   +2 more sources

Vascular endothelial growth factor receptor-1 mRNA overexpression in peripheral blood as a useful prognostic marker in breast cancer [PDF]

, 2012
INTRODUCTION: Identification of useful markers associated with poor prognosis in breast cancer patients is critically needed. We previously showed that expression of vascular endothelial growth factor receptor-1 mRNA in peripheral blood may be useful to ...
Akemi Kataoka, Hiroaki Ueo, Hiroshi Yamaguchi, Koshi Mimori, Masahiko Watanabe, Masaki Mori, Masaru Kuranami, Norihiko Sengoku, Sayuri Akiyoshi, Shinji Ohno, Yoshimasa Kosaka   +10 more
core   +2 more sources