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The Biology of Vascular Endothelial Growth Factor [PDF]

Endocrine Reviews, 1997
The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult1. Neovascularization (angiogenesis) is also implicated in the pathogenesis of a number of disorders.
Napoleone Ferrara, Terri Lynn Davis-Smyth   +1 more
openaire   +4 more sources

Vascular Endothelial Growth Factor A in Intraocular Vascular Disease

Ophthalmology, 2013
The vascular beds supplying the retina may sustain injury as a result of underlying disease such as diabetes, and/or the interaction of genetic predisposition, environmental insults, and age. The vascular pathologic features observed in different intraocular vascular diseases can be categorized broadly as proliferation, exemplified by proliferative ...
Jennifer Le Couter, Erich C. Strauss, Joan W. Miller, Napoleone Ferrara   +3 more
openaire   +4 more sources

Vascular endothelial growth factor signaling in development and disease [PDF]

Development, 2018
ABSTRACT Vascular endothelial growth factors (VEGFs) are best known for their involvement in orchestrating the development and maintenance of the blood and lymphatic vascular systems. VEGFs are secreted by a variety of cells and they bind to their cognate tyrosine kinase VEGF receptors (VEGFRs) in endothelial cells to elicit various ...
Sinem Karaman, Veli-Matti Leppänen, Kari Alitalo   +2 more
openaire   +5 more sources

Vasoregulatory Autoantibodies and Clinical Outcome After Ischemic Stroke—PROSCIS‐B

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Vasoregulatory autoantibodies including autoantibodies targeting G‐protein–coupled receptors might play a functional role in vascular diseases.
Thomas G. Liman, Bob Siegerink, Sophie Piper, Rusan Catar, Guido Moll, Gabriela Riemekasten, Harald Heidecke, Peter U. Heuschmann, Mitchell S. V. Elkind, Duska Dragun, Matthias Endres   +10 more
doaj   +1 more source

Biology of vascular endothelial growth factors [PDF]

FEBS Letters, 2006
Angiogenesis is the process by which new blood vessels are formed from existing vessels. The vascular endothelial growth factors (VEGFs) are considered as key molecules in the process of angiogenesis. The VEGF family currently includes VEGF‐A, ‐B, ‐C, ‐D, ‐E, ‐F and placenta growth factor (PlGF), that bind in a distinct pattern to three structurally ...
Seppo Ylä-Herttuala, Shalini Bhardwaj, Himadri Roy   +2 more
openaire   +3 more sources

Encapsulated VEGF121-PLA microparticles promote angiogenesis in human endometrium stromal cells

Journal of Genetic Engineering and Biotechnology, 2021
Background In this study, Vascular Endothelial Growth Factor 121 expressed abundantly in endometrial stromal cells is encapsulated with poly-l-lactide and characterized the properties for endometrial angiogenesis.
Sunil Abraham, Geetha Sanjay, Noushin Abdul Majiyd, Amutha Chinnaiah   +3 more
doaj   +1 more source

Galectin-3 Enhances Vascular Endothelial Growth Factor-A Receptor 2 Activity in the Presence of Vascular Endothelial Growth Factor

Frontiers in Cell and Developmental Biology, 2021
Galectin-3 (Gal3) is a carbohydrate-binding protein reported to promote angiogenesis by influencing vascular endothelial growth factor-A receptor 2 (VEGFR2) signal transduction.
Issahy Cano, Issahy Cano, Zhengping Hu, Zhengping Hu, Dina B. AbuSamra, Dina B. AbuSamra, Magali Saint-Geniez, Magali Saint-Geniez, Yin Shan Eric Ng, Yin Shan Eric Ng, Pablo Argüeso, Pablo Argüeso, Patricia A. D’Amore, Patricia A. D’Amore, Patricia A. D’Amore   +14 more
doaj   +1 more source

Hypertensive cerebral hemorrhage with undetectable plasma vascular endothelial growth factor levels in a patient receiving intravitreal injection of aflibercept for bilateral diabetic macular edema: a case report

Journal of Medical Case Reports, 2021
Background Intravitreal injections of anti-vascular endothelial growth factor are commonly used to treat macular diseases, including diabetic macular edema.
Miwako Yoshimoto, Nobuhiko Takeda, Takayuki Yoshimoto, Shun Matsumoto   +3 more
doaj   +1 more source

Effect of Different Concentrations of Leukemia Inhibitory Factor on Gene Expression of Vascular Endothelial Growth Factor-A in Trophoblast Tumor Cell Line [PDF]

International Journal of Fertility and Sterility, 2020
Background Several studies have shown that leukemia inhibitory factor (LIF) is one of the most important cytokines participating in the process of embryo implantation and pregnancy, while, the role of this factor on vascular endothelial factor-A (VEGF ...
Khodakaram Jahanbin, Mehri Ghafourian, Mohammad Rashno   +2 more
doaj   +1 more source

Synergistic effect of Si-hydroxyapatite coating and VEGF adsorption on Ti6Al4V-ELI scaffolds for bone regeneration in an osteoporotic bone environment [PDF]

Acta Biomaterialia. 83, 456-466 (2018), 2021
The osteogenic and angiogenic responses to metal macroporous scaffolds coated with silicon substituted hydroxyapatite (SiHA) and decorated with vascular endothelial growth factor (VEGF) have been evaluated in vitro and in vivo. Ti6Al4V-ELI scaffolds were prepared by electron beam melting and subsequently coated with Ca10(PO4)5.6(SiO4)0.4(OH)1.6 ...
arxiv   +1 more source