Results 11 to 20 of about 513,814 (378)
Vascular Smooth Muscle Cells Contribute to Atherosclerosis Immunity
Frontiers in Immunology, 2019 Vascular smooth muscle cells (VSMCs) constitute the major cells in the media layer of arteries, and are critical to maintain the integrity of the arterial wall.
Desheng Hu +5 more
doaj +2 more sources
EPAC in Vascular Smooth Muscle Cells [PDF]
International Journal of Molecular Sciences, 2020 Vascular smooth muscle cells (VSMCs) are major components of blood vessels. They regulate physiological functions, such as vascular tone and blood flow. Under pathological conditions, VSMCs undergo a remodeling process known as phenotypic switching. During this process, VSMCs lose their contractility and acquire a synthetic phenotype, where they over ...
Firas Kobeissy +10 more
openaire +3 more sources
Long non-coding RNAs: Modulators of phenotypic transformation in vascular smooth muscle cells
Frontiers in Cardiovascular Medicine, 2022 Long non-coding RNA (lncRNAs) are longer than 200 nucleotides and cannot encode proteins but can regulate the expression of genes through epigenetic, transcriptional, and post-transcriptional modifications.
Bing-Han Lu +16 more
doaj +1 more source
Vascular smooth muscle cells in intimal hyperplasia, an update
Frontiers in Physiology, 2023 Arterial occlusive disease is the leading cause of death in Western countries. Core contemporary therapies for this disease include angioplasties, stents, endarterectomies and bypass surgery.
S. Déglise +2 more
semanticscholar +1 more source
Vascular smooth muscle cells in atherosclerosis:Time for a reassessment.
Cardiovascular Research, 2021 Vascular smooth muscle cells (VSMCs) are key participants in both early and late-stage atherosclerosis. VSMCs invade the early atherosclerotic lesion from the media, expanding lesions, but also forming a protective fibrous cap rich in extracellular ...
M. Grootaert, M. Bennett
semanticscholar +1 more source
Fate and State of Vascular Smooth Muscle Cells in Atherosclerosis.
Circulation, 2021 Vascular smooth muscle cells (VSMCs) have long been associated with phenotypic modulation/plasticity or dedifferentiation. Innovative technologies in cell lineage tracing, single-cell RNA sequencing, and human genomics have been integrated to gain ...
J. Miano, E. Fisher, M. Majesky
semanticscholar +1 more source
Vinpocetine Attenuates the Osteoblastic Differentiation of Vascular Smooth Muscle Cells. [PDF]
PLoS ONE, 2016 Vascular calcification is an active process of osteoblastic differentiation of vascular smooth muscle cells; however, its definite mechanism remains unknown.
Yun-Yun Ma +8 more
doaj +1 more source
Transcription factor GATA6 promotes migration of human coronary artery smooth muscle cells in vitro
Frontiers in Physiology, 2022 Vascular smooth muscle cell plasticity plays a pivotal role in the pathophysiology of vascular diseases. Despite compelling evidence demonstrating the importance of transcription factor GATA6 in vascular smooth muscle, the functional role of GATA6 ...
Azra Alajbegovic +6 more
doaj +1 more source
The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections
European Journal of Clinical Investigation, 2021 Aortic aneurysms (AA) are pathological dilations of the aorta, associated with an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers can separate by a tear within the layers, defined as aortic dissections (AD).
K. Rombouts +5 more
semanticscholar +1 more source
Smoothelin in Vascular Smooth Muscle Cells [PDF]
Trends in Cardiovascular Medicine, 2007 Smoothelin-A and -B have only been found in fully differentiated contractile smooth muscle cells. They are increasingly used to monitor the smooth muscle cell differentiation process to a contractile or synthetic phenotype. Vascular-specific smoothelin-B is the first smooth muscle cell marker that disappears when vascular tissues are compromised, for ...
Petra Niessen +2 more
openaire +4 more sources