Results 21 to 30 of about 231,096 (267)

α-Smooth Muscle Actin and ACTA2 Gene Expressions in Vasculopathies

Brazilian Journal of Cardiovascular Surgery, 2015
α-smooth muscle actin, encoded by ACTA2 gene, is an isoform of the vascular smooth muscle actins, typically expressed in the vascular smooth muscle cells contributing to vascular motility and contraction. ACTA2 gene mutations cause a diversity of diffuse
Shi-Min Yuan
doaj   +1 more source

Endothelial cell-derived extracellular vesicles alter vascular smooth muscle cell phenotype through high-mobility group box proteins

Journal of Extracellular Vesicles, 2020
The vascular endothelium and smooth muscle form adjacent cellular layers that comprise part of the vascular wall. Each cell type can regulate the other’s structure and function through a variety of paracrine effectors.
Michael J. Boyer, Yayoi Kimura, Tomoko Akiyama, Ariele Y. Baggett, Kyle J. Preston, Rosario Scalia, Satoru Eguchi, Victor Rizzo   +7 more
doaj   +1 more source

Notch2 and Notch3 function together to regulate vascular smooth muscle development. [PDF]

PLoS ONE, 2012
Notch signaling has been implicated in the regulation of smooth muscle differentiation, but the precise role of Notch receptors is ill defined. Although Notch3 receptor expression is high in smooth muscle, Notch3 mutant mice are viable and display only ...
Qingqing Wang, Ning Zhao, Simone Kennard, Brenda Lilly   +3 more
doaj   +1 more source

Quantitative Analysis of Intracellular Ca2+ Release and Contraction in hiPSC-Derived Vascular Smooth Muscle Cells

Stem Cell Reports, 2019
Summary: Vascular smooth muscle cells (vSMCs) are highly heterogeneous across different vascular beds. This is partly dictated by their developmental origin but also their position in the vascular tree, reflected in their differential responses to ...
Oleh V. Halaidych, Amy Cochrane, Francijna E. van den Hil, Christine L. Mummery, Valeria V. Orlova   +4 more
doaj   +1 more source

Vascular smooth muscle cell dysfunction in neurodegeneration

Frontiers in Neuroscience, 2022
Vascular smooth muscle cells (VSMCs) are the key moderators of cerebrovascular dynamics in response to the brain’s oxygen and nutrient demands. Crucially, VSMCs may provide a sensitive biomarker for neurodegenerative pathologies where vasculature is compromised.
Genevieve Hayes, Joana Pinto, Sierra N. Sparks, Congxiyu Wang, Congxiyu Wang, Sana Suri, Sana Suri, Daniel P. Bulte   +7 more
openaire   +3 more sources

Mebendazole reduces vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice.

PLoS ONE, 2014
Mebendazole is an antihelminthic drug that exerts its effects via interference with microtubule function in parasites. To determine the utility of mebendazole as a potential treatment for vascular diseases involving proliferation of vascular smooth ...
Jintao Wang, Hui Wang, Chiao Guo, Wei Luo, Alyssa Lawler, Aswin Reddy, Julia Wang, Eddy B Sun, Daniel T Eitzman   +8 more
doaj   +1 more source

Regulation of vascular smooth muscle cell differentiation [PDF]

Journal of Vascular Surgery, 2007
Vascular smooth muscle cell (VSMC) differentiation is an essential component of vascular development. These cells perform biosynthetic, proliferative, and contractile roles in the vessel wall. VSMCs are not terminally differentiated and are able to modulate their phenotype in response to changing local environmental cues.
Rzucidlo, Eva M., Martin, Kathleen A., Powell, Richard J.   +2 more
openaire   +2 more sources

Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function. [PDF]

PLoS ONE, 2015
Activation of the nuclear hormone receptor, PPARγ, with pharmacological agonists promotes a contractile vascular smooth muscle cell phenotype and reduces oxidative stress and cell proliferation, particularly under pathological conditions including ...
Jennifer M Kleinhenz, Tamara C Murphy, Anastassia P Pokutta-Paskaleva, Rudolph L Gleason, Alicia N Lyle, W Robert Taylor, Mitsi A Blount, Juan Cheng, Qinglin Yang, Roy L Sutliff, C Michael Hart   +10 more
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Nuclear Smooth Muscle α-actin in Vascular Smooth Muscle Cell Differentiation

, 2023
Abstract Missense variants throughout ACTA2, encoding smooth muscle α-actin (αSMA), predispose to adult onset thoracic aortic disease, but variants disrupting arginine 179 (R179) lead to Smooth Muscle Dysfunction Syndrome (SMDS) characterized by childhood-onset diverse vascular diseases.
Callie Kwartler, Albert Pedroza, Anita Kaw, Pujun Guan, Shuangtao Ma, Xue-yan Duan, Caroline Kernell, Charis Wang, Jose Esparza Pinelo, Mikayla Borthwick, Jiyuan Chen, Yuan Zhong, Sanjay Sinha, Xuetong Shen, Michael Fischbein, Dianna Milewicz   +15 more
openaire   +2 more sources

Increased neointimal thickening in dystrophin-deficient mdx mice.

PLoS ONE, 2012
BackgroundThe dystrophin gene, which is mutated in Duchenne muscular dystrophy (DMD), encodes a large cytoskeletal protein present in muscle fibers. While dystrophin in skeletal muscle has been extensively studied, the function of dystrophin in vascular ...
Uwe Rauch, Annelie Shami, Feng Zhang, Virginie Carmignac, Madeleine Durbeej, Anna Hultgårdh-Nilsson   +5 more
doaj   +1 more source