Results 31 to 40 of about 231,096 (267)

Vascular smooth muscle cell senescence in atherosclerosis [PDF]

Cardiovascular Research, 2006
Markers of cell senescence have been identified in both the blood and vessel wall of patients with atherosclerosis. In particular, vascular smooth muscle cells (VSMCs) derived from human plaques show numerous features of senescence both in culture and in vivo.
Isabelle, Gorenne, Mary, Kavurma, Stephen, Scott, Martin, Bennett   +3 more
openaire   +2 more sources

Activation and Contraction of Human “Vascular” Smooth Muscle Cells Grown From Circulating Blood Progenitors

Frontiers in Cell and Developmental Biology, 2021
Blood outgrowth smooth muscle cells (BO-SMCs) offer the means to study vascular cells without the requirement for surgery providing opportunities for drug discovery, tissue engineering, and personalized medicine.
Blerina Ahmetaj-Shala, Isra Marei, Isra Marei, Ryota Kawai, Ryota Kawai, Stephen Rothery, Charis Pericleous, Nura A. Mohamed, Nura A. Mohamed, Hime Gashaw, Kalliopi Bokea, Jake Samuel, Annabelle Vandenheste, Fisnik Shala, Nicholas S. Kirkby, Jane A. Mitchell   +15 more
doaj   +1 more source

Vascular smooth muscle cells

, 2017
Abstract To understand the function of arteries in the regulation of blood supply throughout the body it is essential to realize that the vessel wall is composed predominantly of smooth muscle cells (SMCs) with only one single layer of luminal endothelial cells.
Bochaton-Piallat, Marie-Luce, de Vries, Carlie JM, van Eys, Guillaume J   +2 more
openaire   +2 more sources

Transfer and Expression of the Interferon Gamma Gene in Human Endothelial Cells Inhibits Vascular Smooth Muscle Cell Growth in Vitro

Cell Transplantation, 1997
Intimal hyperplasia in blood vessels is primarily caused by the migration and proliferation of vascular smooth muscle cells. Excessive intimal thickening characterizes atherosclerosis as well as bypass graft and angioplasty failures.
Alison T. Stopeck M.D., Mahmood Vahedian, Stuart K. Williams   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Gasdermin D affects aortic vascular smooth muscle cell pyroptosis and Ang II-induced vascular remodeling

Heliyon, 2023
Vascular smooth muscle cells (VSMCs) are primarily responsible for vasoconstriction and the regulation of blood pressure1. Pyroptosis, a particular form of regulated cell death, is involved in multiple vascular injuries, including hypertensive vascular ...
Zimin Fang, Gaojun Wu, Jian Sheng, Bozhi Ye, Zhouqing Huang, Jianjiang Xu, Jianqin Zhang, Jibo Han, Bingjiang Han, Jiajun Xu   +9 more
doaj   +1 more source

Vascular Smooth Muscle Cell Proliferation in Restenosis [PDF]

Circulation: Cardiovascular Interventions, 2011
Current therapeutic approaches to restore blood flow in stenotic blood vessels involve the use of percutaneous devices and coronary bypass surgery. In all procedures that disrupt the normal integrity of the blood vessels, there is an increased incidence of vessel luminal narrowing, termed restenosis.
Steven O, Marx, Hana, Totary-Jain, Andrew R, Marks   +2 more
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

MicroRNA26 attenuates vascular smooth muscle maturation via endothelial BMP signalling.

PLoS Genetics, 2019
As small regulatory transcripts, microRNAs (miRs) act as genetic 'fine tuners' of posttranscriptional events, and as genetic switches to promote phenotypic switching. The miR miR26a targets the BMP signalling effector, smad1.
Charlene Watterston, Lei Zeng, Abidemi Onabadejo, Sarah J Childs   +3 more
doaj   +1 more source

Short Chain (≤C4) Esterification Increases Bioavailability of Rosmarinic Acid and Its Potency to Inhibit Vascular Smooth Muscle Cell Proliferation

Frontiers in Pharmacology, 2021
Rosmarinic acid is a natural phenolic acid and active compound found in many culinary plants, such as rosemary, mint, basil and perilla. Aiming to improve the pharmacokinetic profile of rosmarinic acid and its activity on vascular smooth muscle cell ...
Tina Blažević, Gottfried Reznicek, Limin Ding, Gangqiang Yang, Patricia Haiss, Elke H. Heiss, Verena M. Dirsch, Rongxia Liu   +7 more
doaj   +1 more source