Results 41 to 50 of about 397,979 (354)

Vascular Smooth Muscle Cells Contribute to Atherosclerosis Immunity

Frontiers in Immunology, 2019
Vascular smooth muscle cells (VSMCs) constitute the major cells in the media layer of arteries, and are critical to maintain the integrity of the arterial wall.
D. Hu, C. Yin, Shanshan Luo, A. Habenicht, Sarajo K. Mohanta   +4 more
semanticscholar   +1 more source

Mebendazole reduces vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice.

PLoS ONE, 2014
Mebendazole is an antihelminthic drug that exerts its effects via interference with microtubule function in parasites. To determine the utility of mebendazole as a potential treatment for vascular diseases involving proliferation of vascular smooth ...
Jintao Wang, Hui Wang, Chiao Guo, Wei Luo, Alyssa Lawler, Aswin Reddy, Julia Wang, Eddy B Sun, Daniel T Eitzman   +8 more
doaj   +1 more source

Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells

Nature Communications, 2018
Abdominal aortic aneurysms (AAA) are characterized by extensive extracellular matrix (ECM) fragmentation and inflammation. However, the mechanisms by which these events are coupled thereby fueling focal vascular damage are undefined.
Tarik Hadi, Ludovic Boytard, M. Silvestro, Dornazsadat Alebrahim, Samson Jacob, J. Feinstein, Krista Barone, Westley Spiro, Susan B. Hutchison, Russell Simon, D. Rateri, F. Pinet, D. Fenyo, M. Adelman, K. Moore, H. Eltzschig, A. Daugherty, Bhama Ramkhelawon   +17 more
semanticscholar   +1 more source

Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis

Autophagy, 2018
Macroautophagy/autophagy is considered as an evolutionarily conserved cellular catabolic process. In this study, we aimed to elucidate the role of autophagy in vascular smooth muscle cells (SMCs) on atherosclerosis.
Yusuke Osonoi, T. Mita, K. Azuma, Kenichi Nakajima, Atsushi Masuyama, Hiromasa Goto, Y. Nishida, T. Miyatsuka, Y. Fujitani, M. Koike, M. Mitsumata, H. Watada   +11 more
semanticscholar   +1 more source

Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells

Nature Communications, 2016
Mural cells of the vessel wall, namely pericytes and vascular smooth muscle cells, are essential for vascular integrity. The developmental sources of these cells and molecular mechanisms controlling their progenitors in the heart are only partially ...
Qi Chen, Hui Zhang, Yang Liu, Susanne Adams, Hanna M. Eilken, M. Stehling, M. Corada, E. Dejana, Bin Zhou, R. Adams   +9 more
semanticscholar   +1 more source

Transdifferentiated Human Vascular Smooth Muscle Cells are a New Potential Cell Source for Endothelial Regeneration

Scientific Reports, 2017
Endothelial dysfunction is widely implicated in cardiovascular pathological changes and development of vascular disease. In view of the fact that the spontaneous endothelial cell (EC) regeneration is a slow and insufficient process, it is of great ...
X. Hong, A. Margariti, Alexandra Le Bras, Laureen Jacquet, W. Kong, Yanhua Hu, Qingbo Xu   +6 more
semanticscholar   +1 more source

Vascular smooth muscle cell differentiation – 2010 [PDF]

Journal of Biomedical Research, 2010
Vascular smooth muscle cells have attracted considerable interest as a model for a flexible program of gene expression. This cell type arises throughout the embryo body plan via poorly understood signaling cascades that direct the expression of transcription factors and microRNAs which, in turn, orchestrate the activation of contractile genes ...
openaire   +3 more sources

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness

Cardiovascular Research, 2018
Vascular calcification is associated with a significant increase in all-cause mortality and atherosclerotic plaque rupture. Calcification has been determined to be an active process driven in part by vascular smooth muscle cell (VSMC ...
A. Durham, Mei Y. Speer, M. Scatena, C. Giachelli, C. Shanahan   +4 more
semanticscholar   +1 more source

Increased neointimal thickening in dystrophin-deficient mdx mice.

PLoS ONE, 2012
BackgroundThe dystrophin gene, which is mutated in Duchenne muscular dystrophy (DMD), encodes a large cytoskeletal protein present in muscle fibers. While dystrophin in skeletal muscle has been extensively studied, the function of dystrophin in vascular ...
Uwe Rauch, Annelie Shami, Feng Zhang, Virginie Carmignac, Madeleine Durbeej, Anna Hultgårdh-Nilsson   +5 more
doaj   +1 more source

Stem cells, vascular smooth muscle cells and atherosclerosis.

Histology and histopathology, 2006
Stem cells have the ability to differentiate into a variety of cells to replace dead cells or to repair tissue. Recently, accumulating evidence indicates that mechanical forces, cytokines and other factors can influence stem cell differentiation into vascular smooth muscle cells (SMCs).
Margariti, A., Zeng, L., Xu, Q.
openaire   +4 more sources