Results 41 to 50 of about 419,114 (213)

Mebendazole reduces vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice.

PLoS ONE, 2014
Mebendazole is an antihelminthic drug that exerts its effects via interference with microtubule function in parasites. To determine the utility of mebendazole as a potential treatment for vascular diseases involving proliferation of vascular smooth ...
Jintao Wang, Hui Wang, Chiao Guo, Wei Luo, Alyssa Lawler, Aswin Reddy, Julia Wang, Eddy B Sun, Daniel T Eitzman   +8 more
doaj   +1 more source

Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function. [PDF]

PLoS ONE, 2015
Activation of the nuclear hormone receptor, PPARγ, with pharmacological agonists promotes a contractile vascular smooth muscle cell phenotype and reduces oxidative stress and cell proliferation, particularly under pathological conditions including ...
Jennifer M Kleinhenz, Tamara C Murphy, Anastassia P Pokutta-Paskaleva, Rudolph L Gleason, Alicia N Lyle, W Robert Taylor, Mitsi A Blount, Juan Cheng, Qinglin Yang, Roy L Sutliff, C Michael Hart   +10 more
doaj   +1 more source

MicroRNAs in pulmonary arterial remodeling [PDF]

, 2013
Pulmonary arterial remodeling is a presently irreversible pathologic hallmark of pulmonary arterial hypertension (PAH). This complex disease involves pathogenic dysregulation of all cell types within the small pulmonary arteries contributing to vascular ...
A Courboulin, A Eulalio, A Ishisaki, A Jelaska, A Kos, A Sacconi, A Tanzer, A Zampetaki, A Zampetaki, AE Frost, AJ Tijsen, AM Walker, Andrew H. Baker, AR Kuhn, AS Flynt, AY Rangrez, AY Yu, B Wojciak-Stothard, BD Adams, BN Davis, BN Davis-Dusenbery, C Atkinson, C Li, C Sweeney, CA Klattenhoff, CD Cool, CL Bockmeyer, D Cifuentes, D Loffler, DB Badesch, DF Liao, DM Patrick, DP Bartel, E Hergenreider, E Mathe, E Rooij Van, ED Michelakis, FE Wang, G Lagna, G Meister, G Simonneau, G Song, GK Owens, H Beppu, H Kang, H Takahashi, H Tazawa, H Valadi, HY Chiang, J Brennecke, J Kim, J Liu, J Niu, J Ryan, J Sarkar, J Skog, J-S Yang, JD Arroyo, Jennifer S. Grant, JH Newman, JM Boucher, JR Thomson, K Abe, K Rakesh, K Wang, KA O’Donnell, KB Lane, KD Taganov, Kevin White, KN Cowan, KR Cordes, KR Stenmark, KR Stenmark, L Elia, L Guo, L He, L He, L Long, L Tu, LA Brennan, LR Frumkin, M Afrakhte, M Brock, M Das, M Deo, M Humbert, M Humbert, M Humbert, M Izikki, M Rabinovitch, M Trabucchi, M Xin, Margaret R. MacLean, MC Chan, MC Chan, MD Moen, MJ Goumans, MM Hoeper, N Liu, N Raver-Shapira, N Volk, NW Morrell, O Platoshyn, P Caruso, P Fasanaro, P Sklepkiewicz, R Kulshreshtha, R Kumarswamy, R Paulin, RD Machado, RJ Dekker, RM O’Connell, S Bonnet, S Chakravarthy, S Jalali, S Mizuno, S Sakamoto, S Sakao, S Yang, SA Moschos, SS Pullamsetti, T Boettger, T Thum, TC Chang, TX Lu, U Bruning, VN Parikh, W Shi, WB Li, X Huang, X Ji, X Long, X Yang, Y Cheng, Y Cheng, Y Ling, Y Liu, YL Jiang   +137 more
core   +2 more sources

HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype. [PDF]

, 2019
Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine SNPs associated with the extent of abdominal aortic calcification (n = 9,417) or descending ...
Bagchi, Aranya, Barnes, Hanna J, Bloch, Donald B, Bowden, Donald W, Budoff, Matthew, Buswell, Mary D, Buys, Emmanuel S, Campbell, Catherine Y, Criqui, Michael H, Debette, Stephanie, Erbel, Raimund, Feitosa, Mary F, Franceschini, Nora, Freedman, Barry I, Gudnason, Vilmundur, Guo, Xiuqing, Harris, Tamara, Hoffmann, Udo, Hwang, Shih-Jen, Johnson, Andrew D, Jöckel, Karl-Heinz, Kälsch, Hagen, Lindsay, Mark E, Lino Cardenas, Christian L, Lu, Lingyi, Malhotra, Rajeev, Mauer, Andreas C, Moebus, Susanne, Nicholson, Christopher J, Nigwekar, Sagar U, Nöthen, Markus M, O'Donnell, Christopher J, Pechlivanis, Sonali, Post, Wendy S, Rhee, David K, Rotter, Jerome I, Rourke, Caitlin O', Shelton, Georgia, Sigurdsson, Sigurdur, Sigurslid, Haakon H, Slocum, Charles, Smith, Albert V, Song, Ci, Thanassoulis, George, Wang, Judy, Wong, Quenna, Wunderer, Florian, Yao, Jie, Zapol, Warren M, Zhang, Xiaoling   +49 more
core   +1 more source

EDHF: An update [PDF]

, 2009
The endothelium controls vascular tone not only by releasing NO and prostacyclin, but also by other pathways causing hyperpolarization of the underlying smooth muscle cells.
Félétou, M, VanHoutte, PM
core   +1 more source

Increased neointimal thickening in dystrophin-deficient mdx mice.

PLoS ONE, 2012
BackgroundThe dystrophin gene, which is mutated in Duchenne muscular dystrophy (DMD), encodes a large cytoskeletal protein present in muscle fibers. While dystrophin in skeletal muscle has been extensively studied, the function of dystrophin in vascular ...
Uwe Rauch, Annelie Shami, Feng Zhang, Virginie Carmignac, Madeleine Durbeej, Anna Hultgårdh-Nilsson   +5 more
doaj   +1 more source

Short Chain (≤C4) Esterification Increases Bioavailability of Rosmarinic Acid and Its Potency to Inhibit Vascular Smooth Muscle Cell Proliferation

Frontiers in Pharmacology, 2021
Rosmarinic acid is a natural phenolic acid and active compound found in many culinary plants, such as rosemary, mint, basil and perilla. Aiming to improve the pharmacokinetic profile of rosmarinic acid and its activity on vascular smooth muscle cell ...
Tina Blažević, Gottfried Reznicek, Limin Ding, Gangqiang Yang, Patricia Haiss, Elke H. Heiss, Verena M. Dirsch, Rongxia Liu   +7 more
doaj   +1 more source

Transfer and Expression of the Interferon Gamma Gene in Human Endothelial Cells Inhibits Vascular Smooth Muscle Cell Growth in Vitro

Cell Transplantation, 1997
Intimal hyperplasia in blood vessels is primarily caused by the migration and proliferation of vascular smooth muscle cells. Excessive intimal thickening characterizes atherosclerosis as well as bypass graft and angioplasty failures.
Alison T. Stopeck M.D., Mahmood Vahedian, Stuart K. Williams   +2 more
doaj   +1 more source

Activation and Contraction of Human “Vascular” Smooth Muscle Cells Grown From Circulating Blood Progenitors

Frontiers in Cell and Developmental Biology, 2021
Blood outgrowth smooth muscle cells (BO-SMCs) offer the means to study vascular cells without the requirement for surgery providing opportunities for drug discovery, tissue engineering, and personalized medicine.
Blerina Ahmetaj-Shala, Isra Marei, Isra Marei, Ryota Kawai, Ryota Kawai, Stephen Rothery, Charis Pericleous, Nura A. Mohamed, Nura A. Mohamed, Hime Gashaw, Kalliopi Bokea, Jake Samuel, Annabelle Vandenheste, Fisnik Shala, Nicholas S. Kirkby, Jane A. Mitchell   +15 more
doaj   +1 more source

MicroRNA26 attenuates vascular smooth muscle maturation via endothelial BMP signalling.

PLoS Genetics, 2019
As small regulatory transcripts, microRNAs (miRs) act as genetic 'fine tuners' of posttranscriptional events, and as genetic switches to promote phenotypic switching. The miR miR26a targets the BMP signalling effector, smad1.
Charlene Watterston, Lei Zeng, Abidemi Onabadejo, Sarah J Childs   +3 more
doaj   +1 more source