Results 41 to 50 of about 513,814 (378)
Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease.
Physiological Reviews, 2017 The cushioning function of large arteries encompasses distension during systole and recoil during diastole which transforms pulsatile flow into a steady flow in the microcirculation.
P. Lacolley +3 more
semanticscholar +1 more source
Numerical Bifurcation Analysis of Pacemaker Dynamics in a Model of Smooth Muscle Cells [PDF]
Bull Math Biol 82, 95 (2020), 2020 Evidence from experimental studies shows that oscillations due to electro-mechanical coupling can be generated spontaneously in smooth muscle cells. Such cellular dynamics are known as \textit{pacemaker dynamics}. In this article we address pacemaker dynamics associated with the interaction of $\text{Ca}^{2+}$ and $\text{K}^+$ fluxes in the cell ...
arxiv +1 more source
Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function. [PDF]
PLoS ONE, 2015 Activation of the nuclear hormone receptor, PPARγ, with pharmacological agonists promotes a contractile vascular smooth muscle cell phenotype and reduces oxidative stress and cell proliferation, particularly under pathological conditions including ...
Jennifer M Kleinhenz +10 more
doaj +1 more source
A model for the generation of localized transient Na+ elevations in vascular smooth muscle [PDF]
Biochem Biophys Res Commun 389, 461-465 (2009), 2009 We present a stochastic computational model to study the mechanism of signalling between a source and a target ionic transporter, both localized on the plasma membrane (PM) and in intracellular nanometre-scale subplasmalemmal signalling compartments comprising the PM, the sarcoplasmic reticulum (SR), Ca2+ and Na+ transporters, and the intervening ...
arxiv +1 more source
PLoS ONE, 2014 Mebendazole is an antihelminthic drug that exerts its effects via interference with microtubule function in parasites. To determine the utility of mebendazole as a potential treatment for vascular diseases involving proliferation of vascular smooth ...
Jintao Wang +8 more
doaj +1 more source
Nature Communications, 2018 Abdominal aortic aneurysms (AAA) are characterized by extensive extracellular matrix (ECM) fragmentation and inflammation. However, the mechanisms by which these events are coupled thereby fueling focal vascular damage are undefined.
Tarik Hadi +17 more
semanticscholar +1 more source
Co-mapping Cellular Content and Extracellular Matrix with Hemodynamics in Intact Arterial Tissues Using Scanning Immunofluorescent Multiphoton Microscopy [PDF]
arXiv, 2023 Deviation of blood flow from an optimal range is known to be associated with the initiation and progression of vascular pathologies. Important open questions remain about how the abnormal flow drives specific wall changes in pathologies such as cerebral aneurysms where the flow is highly heterogeneous and complex.
arxiv
Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells
Nature Communications, 2016 Mural cells of the vessel wall, namely pericytes and vascular smooth muscle cells, are essential for vascular integrity. The developmental sources of these cells and molecular mechanisms controlling their progenitors in the heart are only partially ...
Qi Chen +9 more
semanticscholar +1 more source
Scientific Reports, 2017 Endothelial dysfunction is widely implicated in cardiovascular pathological changes and development of vascular disease. In view of the fact that the spontaneous endothelial cell (EC) regeneration is a slow and insufficient process, it is of great ...
X. Hong +6 more
semanticscholar +1 more source
Cell contractility facilitates alignment of cells and tissues to static uniaxial stretch [PDF]
Biophysical Journal 112 (4): 755-766 (2017), 2016 During animal development and homeostasis, the structure of tissues, including muscles, blood vessels and connective tissues adapts to mechanical strains in the extracellular matrix (ECM). These strains originate from the differential growth of tissues or forces due to muscle contraction or gravity.
arxiv +1 more source