Results 71 to 80 of about 22,016 (234)

PARISROC, a Photomultiplier Array Integrated Read Out Chip [PDF]

, 2009
PARISROC is a complete read out chip, in AMS SiGe 0.35 !m technology, for photomultipliers array. It allows triggerless acquisition for next generation neutrino experiments and it belongs to an R&D program funded by the French national agency for ...
Berni, M. El, Campagne, J. E., De La Taille, C., Di Lorenzo, S. Conforti, Dulucq, F., Martin-Chassard, G., Wei, W.   +6 more
core   +5 more sources

ATP Transport through VDAC and the VDAC–Tubulin Complex Probed by Equilibrium and Nonequilibrium MD Simulations [PDF]

Biochemistry, 2013
Voltage-dependent anion channel (VDAC), the major channel of the mitochondrial outer membrane, serves as a principal pathway for ATP, ADP, and other respiratory substrates across this membrane. Using umbrella-sampling simulations, we established the thermodynamic and kinetic components governing ATP transport across the VDAC1 channel.
Sergei Yu, Noskov, Tatiana K, Rostovtseva, Sergey M, Bezrukov   +2 more
openaire   +2 more sources

PRELID1 and VDAC3 Coordinate a Senescence‐Like State in Germinal Center B Cells to Promote IL‐7–Driven Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
Colorectal cancer is characterized by an immunosuppressive microenvironment that limits immunotherapy efficacy. We identify a senescence‐like state in germinal center B cells driven by the PRELID1–VDAC3 axis, which promotes IL‐7 secretion, alleviates CD8+ T‐cell exhaustion, and enhances antitumor immunity. Targeting this pathway improves responsiveness
Yuhan Liao, Huimeng Xu, Xinghua Zhuo, Shupeng Hu, Lanhui Huang, Zhe Hao, Jianxiong Chen, Yulu Wang, Jun Zhou   +8 more
wiley   +1 more source

Análise interactômica da VDAC (voltage-dependent anion selective channel) nos cérebros aviar, bovino e murino

Pesquisa Veterinária Brasileira, 2011
A VDAC é a proteína mais abundante na membrana mitocondrial externa. Exerce o controle da atividade desta organela através da regulação da troca de metabólitos e tem função crucial no mecanismo de apoptose.
Carla Rossini Crepaldi, Flávia Simone Munin, Phelipe Augusto Mariano Vitale, Marcelo de Cerqueira César   +3 more
doaj   +1 more source

Methylation of the Gpat2 promoter regulates transient expression during mouse spermatogenesis [PDF]

, 2015
Spermatogenesis is a highly regulated process that involves both mitotic and meiotic divisions, as well as cellular differentiation to yield mature spermatozoa from undifferentiated germinal stem cells.
Cattaneo, Elizabeth Renee, Coleman, Rosalind A., Garcia Fabiani, Maria Belen, Gonzalez-Baró, Lacunza, Ezequiel, Montanaro, Mauro Aldo, Pellon Maison, Magali   +6 more
core   +2 more sources

VDAC structure, selectivity, and dynamics

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012
VDAC channels exist in the mitochondrial outer membrane of all eukaryotic organisms. Of the different isoforms present in one organism, it seems that one of these is the canonical VDAC whose properties and 3D structure are highly conserved. The fundamental role of these channels is to control the flux of metabolites between the cytosol and ...
openaire   +2 more sources

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source

VPS13A Deficiency Leads to Impaired Lipid Distribution and Alteration of Mitochondrial Calcium Homeostasis in Fibroblasts of VPS13A Disease Patients

Movement Disorders, EarlyView.
Abstract Background Membrane contact sites are crucial for the exchange of ions or lipids and thus are critical for the function and maintenance of organelles. VPS13A is a membrane‐residing, bridge‐like protein connecting two membranes to enable bulk lipid transfer. Loss‐of‐function mutations in the VPS13A gene cause VPS13A disease.
Dajana Grossmann, Adrian Spranger, Emily Fischer, Johanna W. Schubarth, Jenny Leopold, Hannes Glaß, Sebastian Klicker, My Uyen Dang Thi, Anna Elisabeth Bartalis, Andreas Hermann, Kevin Peikert   +10 more
wiley   +1 more source

Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. [PDF]

, 2014
Tightly regulated Ca(2+) homeostasis is a prerequisite for proper cardiac function. To dissect the regulatory network of cardiac Ca(2+) handling, we performed a chemical suppressor screen on zebrafish tremblor embryos, which suffer from Ca(2+) extrusion ...
Chen, Jau-Nian, Ehrlich, Amy, Fiji, Hannah Dg, Franklin, Sarah, Gimzewski, James K, Goldhaber, Joshua I., Hajnóczky, György, Huang, Jie, Kwon, Ohyun, Lin, Billy, Lu, Fei, Lu, Kui, Naghdi, Shamim, Nakai, Junichi, Nakano, Atsushi, Nakano, Haruko, Schredelseker, Johann, Shimizu, Hirohito, Stieg, Adam Z, Tian, Cheng, Vondriska, Thomas M., Wang, Kevin, Zhu, Huanqi   +22 more
core   +2 more sources

VDAC closure increases calcium ion flux

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007
VDAC is the major permeability pathway in the mitochondrial outer membrane and can control the flow of metabolites and ions. Therefore Ca(2+) flux across the outer membrane occurs mainly through VDAC. Since both Ca(2+) fluxes and VDAC are involved in apoptosis, we examined whether Ca(2+) is required for channel formation by VDAC isolated from rat liver.
Tan, Wenzhi, Colombini, Marco
openaire   +2 more sources