Results 81 to 90 of about 22,016 (234)

Regulation of VDAC trafficking modulates cell death [PDF]

Cell Death Discovery, 2016
AbstractThe voltage-dependent anion channel (VDAC) and mitochondria-associated hexokinase (HxK) have crucial roles in both cell survival and death. Both the individual abundances and their ratio seem to influence the balance of survival and death and are thus critical in scenarios, such as neurodegeneration and cancer.
Dubey, Ashvini K, Godbole, Ashwini, Mathew, M K   +2 more
openaire   +2 more sources

Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis

PROTEOMICS, EarlyView.
ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan, Clinton J. Bradfield, Sandhini Saha, Sung Hwan Yoon, Iain D. C. Fraser, Aleksandra Nita‐Lazar   +5 more
wiley   +1 more source

Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells. [PDF]

PLoS ONE, 2016
We here evaluated the potential anti-colorectal cancer activity by erastin, a voltage-dependent anion channel (VDAC)-binding compound. Our in vitro studies showed that erastin exerted potent cytotoxic effects against multiple human colorectal cancer cell
Haizhong Huo, Zhiyuan Zhou, Jian Qin, Wenyong Liu, Bing Wang, Yan Gu   +5 more
doaj   +1 more source

Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control [PDF]

, 2018
The deglycase and chaperone protein DJ-1 is pivotal for cellular oxidative stress responses and mitochondrial quality control. Mutations in PARK7, encoding DJ-1, are associated with early-onset familial Parkinson’s disease and lead to pathological ...
Abeti, Abou-Sleiman, Adam-Vizi, Alexis A. Robinson, Ariga, Banerjee, Ben-Nissan, Blackinton, Boland, Bonifati, Bonifati, Brenner-Lavie, Campanella, Canet-Avilés, Cannon, Carlo Rodolfo, Caterina Ferraina, Chen, Daniela Strobbe, Dauer, Dias, Duchen, D’Autréaux, East, Gatliff, Georgakopoulos, Giaime, Giordano, Görner, Harvey, Hulleman, Junn, Kahle, Kim, Kirsten Harvey, Lakshminarasimhan, Lara Rossi, Lücking, Maita, Martinat, Martinez-Vicente, Matic, Michelangelo Campanella, Moscovitz, Muller, Murphy, Narendra, Niki, Olzmann, Ono, Onyango, Paisán-Ruíz, Pankratz, Parker, Parsanejad, Polymeropoulos, Robert J. Harvey, Schon, Shendelman, Shinbo, Taira, Takahashi, Takahashi-Niki, Valente, Valerio de Biase, Waak, Wang   +66 more
core   +3 more sources

Modulation of Plant Mitochondrial VDAC by Phytosterols [PDF]

Biophysical Journal, 2010
We have investigated the effect of cholesterol and two abundant phytosterols (sitosterol and stigmasterol) on the voltage-dependent anion-selective channel (VDAC) purified from mitochondria of bean seeds (Phaseolus coccineus). These sterols differ by the degree of freedom of their lateral chain.
Mlayeh, Lamia, Chatkaew, Sunita, Léonetti, M, Homblé, Fabrice   +3 more
openaire   +2 more sources

Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual‐Action Therapeutic Strategy

Phytotherapy Research, EarlyView.
ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte, Sílvia Santos Pedrosa, P. Raaj Khusial, Ana Raquel Madureira   +3 more
wiley   +1 more source

Purificação e caracterização da VDAC de mitocôndrias corticais aviares: identificação de modificações pós-traducionais nas porinas neuronais murinas e aviares Purification and characterization of avian cortical mitochondrial VDAC: identification of post-translational modifications of rat and avian neuronal porins

Pesquisa Veterinária Brasileira, 2012
A VDAC é uma porina presente na MME cuja função é crucial no metabolismo energético, sobrevivência e morte celular. A caracterização da VDAC torna-se importante para a compreensão das inter-relações da mitocôndria com os diferentes componentes ...
Phelipe Augusto Mariano Vitale, Carla Rossini Crepaldi, Andréa Cristina Tesch, Ricardo de Albuquerque, Marcelo de Cerqueira César   +4 more
doaj  

Purificação e caracterização da VDAC de mitocôndrias corticais aviares: identificação de modificações pós-traducionais nas porinas neuronais murinas e aviares

Pesquisa Veterinária Brasileira, 2012
A VDAC é uma porina presente na MME cuja função é crucial no metabolismo energético, sobrevivência e morte celular. A caracterização da VDAC torna-se importante para a compreensão das inter-relações da mitocôndria com os diferentes componentes ...
Phelipe Augusto Mariano Vitale, Carla Rossini Crepaldi, Andréa Cristina Tesch, Ricardo de Albuquerque, Marcelo de Cerqueira César   +4 more
doaj   +1 more source

Nanoporous silica-based protocells at multiple scales for designs of life and nanomedicine. [PDF]

, 2015
Various protocell models have been constructed de novo with the bottom-up approach. Here we describe a silica-based protocell composed of a nanoporous amorphous silica core encapsulated within a lipid bilayer built by self-assembly that provides for ...
Brinker, C Jeffrey, Jakobsson, Eric, Sun, Jie, Wang, Yingxiao   +3 more
core   +2 more sources

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source