Signaling pathways regulating VDAC1 overexpression associated with apoptosis, pyroptosis, and ferroptosis [PDF]
Cell Communication and SignalingMitochondrial VDAC1 is a multi-functional protein that acts as a convergence point for various cell survival and death signals. Under stress and pathological conditions, VDAC1 is overexpressed.
Aditya Karunanithi Nivedita +6 more
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p53 Interacts with VDAC1, Modulating Its Expression Level and Oligomeric State to Activate Apoptosis [PDF]
BiomoleculesThe p53 tumor suppressor, a key transcription factor, acts as a cellular stress sensor that regulates hundreds of genes involved in responses to DNA damage, oxidative stress, and ischemia.
Elinor Gigi +5 more
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HSP90AA1–VDAC1 interaction contributes to breast cancer progression and doxorubicin resistance through PI3K/AKT signaling [PDF]
Breast Cancer ResearchBackground Chemotherapy resistance remains a major obstacle to durable control of breast cancer (BC), particularly to doxorubicin (DOX). Heat shock protein 90 alpha family class A member 1 (HSP90AA1) and the mitochondrial outer-membrane channel VDAC1 ...
Yutong Fang +6 more
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DIDS modulates VDAC1 oligomerization to suppress intrinsic apoptosis and attenuates in vitro and in vivo RSV infection [PDF]
Journal of VirologyHuman respiratory syncytial virus (RSV) is a major pathogen causing acute lower respiratory tract infections in infants, young children, and elderly people worldwide. Viruses often hijack host cell ion channels to optimize their intracellular environment,
Siyu Lin +14 more
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VDAC1 Intervention Alleviates Bisphenol AF-Induced Succinate Metabolism Dysregulation and Inflammatory Responses [PDF]
PharmaceuticalsBackground/Objectives: Bisphenol AF (BPAF) is a prevalent environmental contaminant with demonstrated metabolic and immunological toxicity. This study aimed to investigate whether VDAC1 (Voltage-Dependent Anion Channel 1) mediates BPAF-induced succinate ...
Xinyu Hong +7 more
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Neoplasia: An International Journal for Oncology Research, 2023 Voltage-dependent anion-selective channel protein 1 (VDAC1) is the most abundant protein in the mitochondrial outer membrane and plays a crucial role in the control of hepatocellular carcinoma (HCC) progress.
Jinxin Zhang +17 more
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VDAC1-based peptide as potential treatment for pathologies of the liver and pancreas
Медицинский совет, 2022 Diseases associated with damage to such vital organs of the digestive system as the liver and pancreas are an urgent problem of world health. Non-alcoholic fatty liver disease (NAFLD) is a worldwide epidemic; the problem of type 2 diabetes (T2D) mellitus
V. N. Nikolenko +3 more
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VDAC1 regulates neuronal cell loss after retinal trauma injury by a mitochondria-independent pathway
Cell Death and Disease, 2022 The voltage-dependent anion channel 1 (VDAC1) was first described as a mitochondrial porin that mediates the flux of metabolites and ions, thereby integrating both cell survival and death signals.
Erica de Sousa +9 more
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World Journal of Surgical Oncology, 2022 Background More and more evidence suggests that cancer is a mitochondrial metabolic disease recently and mitochondria dysfunction is critical to tumorigenesis.
Yutong Fang +8 more
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Cells, 2022 The multifunctional protein, voltage-dependent anion channel 1 (VDAC1), is located on the mitochondrial outer membrane. It is a pivotal protein that maintains mitochondrial function to power cellular bioactivities via energy generation. VDAC1 is involved
Hang Hu +3 more
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