Results 11 to 20 of about 9,347 (172)

VDAC1: From structure to cancer therapy [PDF]

Frontiers in Oncology, 2012
Here, we review current evidence pointing to the function of VDAC1 in cell life and death, and highlight these functions in relation to cancer. Found at the outer mitochondrial membrane, VDAC1 assumes a crucial position in the cell, controlling the ...
Varda eShoshan-Barmatz, Dario eMizrachi
doaj   +3 more sources

Human erythroid differentiation requires VDAC1-mediated mitochondrial clearance

Haematologica, 2021
Erythroblast maturation in mammals is dependent on organelle clearance throughout terminal erythropoiesis. We studied the role of the outer mitochondrial membrane protein voltage-dependent anion channel-1 (VDAC1) in human terminal erythropoiesis.
Martina Moras, Claude Hattab, Pedro Gonzalez-Menendez, Claudio M. Fader, Michael Dussiot, Jerome Larghero, Caroline Le Van Kim, Sandrina Kinet, Naomi Taylor, Sophie D. Lefevre, Mariano A. Ostuni   +10 more
doaj   +6 more sources

A VDAC1-Derived N-Terminal Peptide Inhibits Mutant SOD1-VDAC1 Interactions and Toxicity in the SOD1 Model of ALS [PDF]

Frontiers in Cellular Neuroscience, 2019
Mutations in superoxide dismutase (SOD1) are the second most common cause of familial amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease caused by the death of motor neurons in the brain and spinal cord.
Anna Shteinfer-Kuzmine, Shirel Argueti, Rajeev Gupta, Neta Shvil, Salah Abu-Hamad, Yael Gropper, Jan Hoeber, Andrea Magrì, Angela Messina, Elena N. Kozlova, Varda Shoshan-Barmatz, Adrian Israelson   +11 more
doaj   +5 more sources

VDAC1 in the diseased myocardium and the effect of VDAC1-interacting compound on atrial fibrosis induced by hyperaldosteronism [PDF]

Scientific Reports, 2020
The voltage-dependent anion channel 1 (VDAC1) is a key player in mitochondrial function. VDAC1 serves as a gatekeeper mediating the fluxes of ions, nucleotides, and other metabolites across the outer mitochondrial membrane, as well as the release of ...
Hadar Klapper-Goldstein, Ankit Verma, Sigal Elyagon, Roni Gillis, Michael Murninkas, Srinivas Pittala, Avijit Paul, Varda Shoshan-Barmatz, Yoram Etzion   +8 more
doaj   +3 more sources

Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target [PDF]

Frontiers in Physiology, 2017
Mitochondria are the key source of ATP that fuels cellular functions, and they are also central in cellular signaling, cell division and apoptosis. Dysfunction of mitochondria has been implicated in a wide range of diseases, including neurodegenerative ...
Amadou K. S. Camara, Amadou K. S. Camara, YiFan Zhou, Po-Chao Wen, Emad Tajkhorshid, Wai-Meng Kwok, Wai-Meng Kwok, Wai-Meng Kwok   +7 more
doaj   +3 more sources

The Multicellular Effects of VDAC1 N-Terminal-Derived Peptide

Biomolecules, 2022
The mitochondrial voltage-dependent anion channel-1 (VDAC1) protein functions in a variety of mitochondria-linked physiological and pathological processes, including metabolism and cell signaling, as well as in mitochondria-mediated apoptosis.
Uttpal Anand, Anna Shteinfer-Kuzmine, Gal Sela, Manikandan Santhanam, Benjamin Gottschalk, Rajaa Boujemaa-Paterski, Ohad Medalia, Wolfgang F. Graier, Varda Shoshan-Barmatz   +8 more
doaj   +4 more sources

Decoding Cancer through Silencing the Mitochondrial Gatekeeper VDAC1

Biomolecules
Mitochondria serve as central hubs for regulating numerous cellular processes that include metabolism, apoptosis, cell cycle progression, proliferation, differentiation, epigenetics, immune signaling, and aging.
Tasleem Arif, Anna Shteinfer-Kuzmine, Varda Shoshan-Barmatz   +2 more
doaj   +3 more sources

VDAC1-Based Peptides as Potential Modulators of VDAC1 Interactions with Its Partners and as a Therapeutic for Cancer, NASH, and Diabetes

Biomolecules
This review presents current knowledge related to the voltage-dependent anion channel-1 (VDAC1) as a multi-functional mitochondrial protein that acts in regulating both cell life and death.
Anna Shteinfer-Kuzmine, Manikandan Santhanam, Varda Shoshan-Barmatz   +2 more
doaj   +3 more sources

Metformin-Induced Apoptosis Is Mediated Through Mitochondrial VDAC1

Pharmaceuticals
Background: Besides diabetes mellitus, metformin has been identified as a potential therapeutic agent for treating various other conditions that include various cancers, cardiovascular diseases, neurodegenerative diseases, and aging. In cancer, metformin
Anna Shteinfer-Kuzmine, Meital M. Moyal, Aditya Karunanithi Nivedita, Sweta Trishna, Almog Nadir, Shubhandra Tripathi, Varda Shoshan-Barmatz   +6 more
doaj   +2 more sources

VDAC1 Negatively Regulates Floral Transition in Arabidopsis thaliana [PDF]

International Journal of Molecular Sciences, 2021
Voltage-dependent anion channels (VDACs) are the most important proteins in mitochondria. They localize to the outer mitochondrial membrane and contribute to the metabolite transport between the mitochondria and cytoplasm, which aids plant growth regulation.
Jingya Xu, Yuzhen Zhang, Hongjia Ren, Runyi Yu, Chen Yuan, Yikai Hu, Rumeng Xu, Xuming Wang, Cheng Qin   +8 more
openaire   +2 more sources