Results 21 to 30 of about 9,347 (172)
VDAC1: A Key Player in the Mitochondrial Landscape of Neurodegeneration
BiomoleculesVoltage-Dependent Anion Channel 1 (VDAC1) is a mitochondrial outer membrane protein that plays a crucial role in regulating cellular energy metabolism and apoptosis by mediating the exchange of ions and metabolites between mitochondria and the cytosol ...
Shirel Argueti-Ostrovsky +3 more
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Investigating VDAC1 Orientation In Vivo [PDF]
Biophysical Journal, 2010 VDAC is an important and abundant ion channel in mitochondrial outer membranes but its structure remained unclear until recent structures of human VDAC1 revealed a 19 stranded β-barrel. Nevertheless there are still unresolved questions concerning the orientation of VDAC in the membrane and its fine structure.
Lakey, Jeremy H. +3 more
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VDAC1 Is a Transplasma Membrane NADH-Ferricyanide Reductase [PDF]
Journal of Biological Chemistry, 2004 Porin isoform 1 or VDAC (voltage-dependent anion-selective channel) 1 is the predominant protein in the outer mitochondrial membrane. We demonstrated previously that a plasma membrane NADH-ferricyanide reductase activity becomes up-regulated upon mitochondrial perturbation, and therefore suggested that it functions as a cellular redox sensor.
M. A. BAKER +4 more
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VDAC1 (voltage-dependent anion channel 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on VDAC1 (voltage-dependent anion channel 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Shoshan-Barmatz, V, Mizrachi, D
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Mediators of Inflammation, 2023 Beta-amyloid (Aβ) accumulation in the brains of Alzheimer’s disease (AD) patients leads to mitochondrial dysfunction and ferroptosis in neurons. Voltage-dependent anion channel 1 (VDAC1) is a major protein in the mitochondrial outer membrane. It has been
Xinpei Zhou +9 more
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Вавиловский журнал генетики и селекции, 2023 The phenomenon of DNA import into mitochondria has been shown for all major groups of eukaryotes. In plants and animals, DNA import seems to occur in different ways. It has been known that nucleic acids enter plant organelles through alternative channels,
T. A. Tarasenko +4 more
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VDAC1-interacting anion transport inhibitors inhibit VDAC1 oligomerization and apoptosis
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2016 Mitochondria-mediated apoptosis involves pro-apoptotic protein release from the mitochondria to the cytosol, triggering apoptosis. However, the mechanisms by which apoptotic initiators cross the outer mitochondrial membrane (OMM) remain unclear. The voltage-dependent anion channel 1 (VDAC1), an OMM protein, is central to mitochondria-mediated apoptosis.
Danya, Ben-Hail, Varda, Shoshan-Barmatz
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PGC1α and VDAC1 expression in endometrial cancer
Molecular and Clinical Oncology, 2020 Endometrial cancer (EC) is one of the ten most common gynecological cancers. As in most cancers, EC tumour progression involves alterations in cellular metabolism and can be associated with, for instance, altered levels of glycolytic enzymes. Mitochondrial functions and proteins are known to serve key roles in tumour metabolism and progression.
Ofra Castro, Wersäll +5 more
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Probing the orientation of yeast VDAC1 in vivo [PDF]
FEBS Letters, 2009 Voltage dependent anion channel (VDAC) is a vital ion channel in mitochondrial outer membranes and its structure was recently shown to be a 19 stranded β‐barrel. However the orientation of VDAC in the membrane remains unclear. We probe here the topology and membrane orientation of yeast Saccharomyces cerevisiae in vivo.
McDonald BM +3 more
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News about VDAC1 in Hypoxia [PDF]
Frontiers in Oncology, 2016 The voltage-dependent anion channel (VDAC) is the main interface between the cytosol and mitochondria of cells. It plays a crucial role in both mitochondrial metabolism and cell death. The main basic function of this channel is to mediate and gate the flux of small ions, metabolites, and adenosine triphosphate.
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