Results 261 to 270 of about 2,633,569 (375)

Endothelial cells as targets of immune checkpoint blockade. [PDF]

J Immunother Cancer
Korman AJ, Taylor M, Stephen Hodi F.
europepmc   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Pregnancy hormones increase cardiac capillary density via the PGC-1α/ERRα/VEGF pathway in cardiomyocytes. [PDF]

Front Cardiovasc Med
Hesse M, Korzus D, Thaben K, Wagner N, Ergün S, Arany Z, Fleischmann BK.   +6 more
europepmc   +1 more source

Classification of renal cell carcinoma based on expression of VEGF and VEGF receptors in both tumor cells and endothelial cells

Laboratory Investigation, 2008
H. Kluger, Summar F. Siddiqui, C. Angeletti, M. Sznol, W. Kelly, A. Molinaro, R. Camp   +6 more
semanticscholar   +1 more source

Folic Acid‐Modified Ginger‐Derived Exosome‐Like Nanoparticles Co‐Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K‐Akt Pathway Inhibition, P‐gp Downregulation, and Macrophage Reprogramming

Advanced Science, EarlyView.
FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu, Daixing Hu, Shixue Liu, Lei Yang, Junwu Li, Yuanyuan Bai, Guozhi Zhao, Wei Tang, Li Jiang   +8 more
wiley   +1 more source

NMDA receptors coordinate brain vascular development via neuron-to-endothelial tip cell crosstalk in zebrafish. [PDF]

Nat Commun
Liu TT, Li HY, Gu SY, Sun L, Zhang RW, Zu JL, Zhang Y, Yu SG, Zheng XD, Yin JA, Chen Q, He J, Xu B, Du JL.   +13 more
europepmc   +1 more source

VEGF and VEGF receptors in human medulloblastoma

, 2008
Gardiman, M, Fassan, M, Denaro, L, Perilongo, G, Onisto, M, Rosolen, A, d'Avella, D   +6 more
openaire   +1 more source

Near‐Infrared Switch‐Driven Macrophage Dynamically Reprogramming for Anti‐Infection and Tissue Healing on Polyetheretherketone Implants

Advanced Science, EarlyView.
This study develops a Mg‐H‐SPEEK implant with NIR‐switchable immunomodulatory properties. Under NIR, it promotes M1 macrophages for antibacterial action; without NIR, it induces M2 reprogramming to enhance tissue healing. This dual‐function material offers a smart strategy for reducing infection and improving integration in percutaneous implants ...
Yinghao Wu, Shuaiqi Jiang, Jibing He, Ji Tan, Junjie Zhou, Zhipeng Zou, Jiaxing Wang, Jia Jiang, Xuanyong Liu, Xiaochun Peng   +9 more
wiley   +1 more source

Opinion: Inhibition of Blood-Brain Barrier Repair as a Mechanism in HIV-1 Disease. [PDF]

, 2017
Maubert, Monique E., Nonnemacher, Michael R., Wigdahl, Brian   +2 more
core   +2 more sources