Results 51 to 60 of about 8,038 (173)

Cellular Signalling Networks in High Altitude Pulmonary Hypertension: From Canonical Pathways to Emerging Targets

Cell Proliferation, EarlyView.
This review elucidates the intricate cellular signalling networks involved in high‐altitude pulmonary hypertension (HAPH), integrating canonical pathways like HIF, MAPK and BMP with emerging targets such as Wnt/β‐catenin, Notch, Hippo‐YAP and IL‐6. It highlights potential therapeutic strategies targeting these pathways to mitigate vascular remodelling ...
Sheng Ding, Ju Chen, Zhaoyang Li, Yang Yu, Weijie Wang, Yan Liao, Jin Yang, Dianxiang Lu, Yujiang Fan   +8 more
wiley   +1 more source

Distribution of versican and hyaluronan in the mouse uterus during decidualization

Brazilian Journal of Medical and Biological Research, 2003
Preparation for embryo implantation requires extensive adaptation of the uterine microenvironment. This process consists of cell proliferation and cell differentiation resulting in the transformation of endometrial fibroblasts into a new type of cell ...
S. San Martin, M. Soto-Suazo, T.M.T. Zorn   +2 more
doaj   +1 more source

Hyaluronate binding properties of versican.

Journal of Biological Chemistry, 1992
We have previously cloned a large chondroitin sulfate proteoglycan (versican) from human fibroblasts. The primary sequence shows that the N terminus contains sequence homology with known hyaluronate-binding molecule, suggesting that versican can bind hyaluronate.
R G, LeBaron, D R, Zimmermann, E, Ruoslahti   +2 more
openaire   +2 more sources

Rutin Stabilises β‐Catenin Through GSK3β Inhibition to Promote Hair Follicle Regeneration

Cell Proliferation, EarlyView.
Rutin directly binds to GSK3β, stabilising β‐catenin and activating Wnt/β‐catenin signalling to drive hair cycle.
Yanyan Zhang, Yuanjie Zhu, Mengyu Jin, Jing Chen, Siqi Yuan, Minjia Yuan, Yuou Sha, Qingmei Liu, Wenyu Wu, Juan Wang, Xiaolei Ding   +10 more
wiley   +1 more source

Optimal stimulation toward the dermal papilla lineage can be promoted by combined use of osteogenic and adipogenic inducers

FEBS Open Bio, 2020
Dermal papilla cells (DPCs) play crucial roles in hair regeneration, but they readily lose their hair‐forming ability during in vitro culture. Although the formation of spheroids partially restores the ability, shrinkage of the spheroids makes it ...
Taheruzzaman Kazi, Ichitaro Niibe, Akio Nishikawa, Takashi Matsuzaki   +3 more
doaj   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

HER-2 and EGFR mRNA Expression and Its Relationship with Versican in Malignant Matrix-Producing Tumors of the Canine Mammary Gland.

PLoS ONE, 2016
Versican expression promotes tumor growth by destabilizing focal cell contacts, thus impeding cell adhesion and facilitating cell migration. It not only presents or recruits molecules to the cell surface, but also modulates gene expression levels and ...
Karine Araújo Damasceno, Enio Ferreira, Alessandra Estrela-Lima, Conrado de Oliveira Gamba, Fernanda Freitas Miranda, Mariana Rezende Alves, Rafael Malagoli Rocha, André Luís Branco de Barros, Geovanni Dantas Cassali   +8 more
doaj   +1 more source

Versican V0 and V1 Guide Migratory Neural Crest Cells [PDF]

Journal of Biological Chemistry, 2006
We previously showed the selective expression of the chondroitin sulfate proteoglycans versican V0 and V1 in barrier tissues that impede the migration of neural crest cells during embryonic trunk development (Landolt, R. M., Vaughan, L., Winterhalter, K. H., and Zimmermann, D. R. (1995) Development 212, 2303-2312).
Dutt, Shilpee, Kléber, Maurice, Matasci, Mattia, Sommer, Lukas, Zimmermann, Dieter R   +4 more
openaire   +2 more sources

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source