Results 91 to 100 of about 54,904 (251)

Single‐molecule validation and optimised protocols for the use of secondary nanobodies in multiplexed immunoassays

Journal of Microscopy, EarlyView.
Abstract Recently developed secondary nanobodies or single‐domain antibodies present a powerful tool for immunodetection. Unlike traditional antibodies, their monovalence enables pre‐association with primary antibodies prior to sample staining, presenting a straightforward affinity‐based antibody labelling solution.
Rebecca Saleeb, Judi O'Shaughnessy, Ryan Ferguson, Candace T. Adams, Mathew H. Horrocks   +4 more
wiley   +1 more source

Enhancement of Polymeric Immunoglobulin Receptor Transcytosis by Biparatopic VHH

PLoS ONE, 2011
The polymeric immunoglobulin receptor (pIgR) ensures the transport of dimeric immunoglobulin A (dIgA) and pentameric immunoglobulin M (pIgM) across epithelia to the mucosal layer of for example the intestines and the lungs via transcytosis. Per day the human pIgR mediates the excretion of 2 to 5 grams of dIgA into the mucosa of luminal organs.
Chris D Emmerson, Els J van der Vlist, Myrthe R Braam, Peter Vanlandschoot, Pascal Merchiers, Hans J W de Haard, C Theo Verrips, Paul M P van Bergen en Henegouwen, Edward Dolk   +8 more
openaire   +4 more sources

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly [PDF]

, 2016
Myeloid cells assemble inflammasomes in response to infection or cell damage; cytosolic sensors activate pro–caspase-1, indirectly for the most part, via the adaptors ASC and NLRC4. This leads to secretion of proinflammatory cytokines and pyroptosis.
Adams, Aida, Alvin Lu, Antonin, Arora, Ashour, Barrios-Rodiles, Broz, Broz, Burg, Cai, Catherine Tang, Chakrabarti, Chen, Conrath, de Alba, Delaloye, Doxsey, Emsley, Fernandes-Alnemri, Ferrao, Florian I. Schmidt, Guimaraes, Hamers-Casterman, Hao Wu, Hauenstein, Helma, Hidde L. Ploegh, Hornung, Hu, Irannejad, Jakobs, Jeff W. Chen, Jianbin Ruan, Kagan, Kirchhofer, Kortmann, Lechtenberg, Lin, Lu, Maass, Man, Masumoto, Masumoto, Meerbrey, Milne, Muyldermans, Paalanen, Pardon, Sahillioglu, Sborgi, Shenoy, Sosa, Taipale, Vanaja, Vance, Wu, Wu, Yang, Young, Zhang   +60 more
core   +1 more source

Advancing a virtual home hospital: a blueprint for development and expansion

BMJ Open Quality
Background The rising demand for hospitals has spurred increased interest in adopting virtual home hospital (VHH) care models. Development in this area often uses rigid research methods.
Pamela Mathura, Natalie McMurtry, Narmin Kassam, Greg Hrynchyshyn, Isabella Pascheto, Haley Dytoc-Fong   +5 more
doaj   +1 more source

Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants

Advanced Therapeutics, Volume 9, Issue 1, January 2026.
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack, Urszula Orzeł, Anja Schlör, Sourabh Mehta, Anandi Krishnan, Slawomir Filipek, Rushika Patel, Madhvi Joshi, Markus Hoffmann, Stefan Pöhlmann, Chaitanya Joshi, Dorian Liepmann, Ramasamy Paulmurugan, Venkatesan Renugopalakrishnan   +13 more
wiley   +1 more source

Land reform, poverty reduction and growth : evidence from India [PDF]

, 1998
In recent times there has been a renewed interest in relationships between redistribution, growth and welfare. Land reforms have been central to strategies to improve the asset base of the poor in developing countries thought their effectiveness has been
Besley, Timothy, Burgess, Robin
core  

Continuous Suppression of Pathological Retinal and Choroidal Neovascularization in Cynomolgus Monkeys via Noninvasive Ophthalmic Delivery of a Novel Anti‐VEGFA Nanobody and Proprietary Penetratin Analog Formulation

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Pathological retinal/choroidal neovascularization drives vision loss in DR and AMD. Current anti‐VEGF injections, while effective, require invasive, frequent administration. Pene/LQ015, is developed a novel topical anti‐VEGFA nanobody formulation achieving therapeutic intraocular levels through penetratin analog‐enhanced delivery.
Chong Chen, Min Zhu, Xingyan Fan, Kangjia Lv, Kuan Jiang, Yuchen Zhang, Haoliang Zhang, Xinming Qi, Benjamin TK Lee, Yakun Wan, Gang Wei, Kun Liu, Xun Xu   +12 more
wiley   +1 more source

Cloning and Expression of Nano Body Gene against Enterotoxin B of Staphylococcus Aureus [PDF]

Journal of Advanced Biomedical Sciences, 2016
Background & Objectives: Staphylococcus aureus bacteria causes many different diseases by secretion of various enterotoxins. Therefore, it is necessary to develop ways that facilitate the detection of enterotoxins.
Zahra Tavassoli, Hamideh Rouhani Nejad, Jalil Fallah Mehrabadi   +2 more
doaj  

Botulinum Neurotoxins and Botulism: A Novel Therapeutic Approach

Toxins, 2011
Specific treatment is not available for human botulism. Current remedial mainstay is the passive administration of polyclonal antibody to botulinum neurotoxin (BoNT) derived from heterologous species (immunized animal or mouse hybridoma) together with ...
Wanpen Chaicumpa, Jeeraphong Thanongsaksrikul   +1 more
doaj   +1 more source

The dynamics of public opinion under majority rules

, 2001
This note explains the process of public opinion formation via a locally interactive, space-time analysis. The model we use is a special case of the general framework for modelling social interaction proposed in Blume and Durlauf (2001).
Corradi, V., Ianni, A.
core