Results 101 to 110 of about 57,494 (245)

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

open access: yesCytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source

Nanobody and Its Therapeutic Applications

open access: yesJournal of Mazandaran University of Medical Sciences, 2018
Background and purpose: Monoclonal antibodies market has grown since approval of Muromonab-CD3 (trade name Orthoclone OKT3) in 1986 as immuno- suppressor.
Maryam Darvish
doaj  

A novel single-domain antibody multimer that potently neutralizes tetanus neurotoxin

open access: yesVaccine: X, 2021
Tetanus antitoxin, produced in animals, has been used for the prevention and treatment of tetanus for more than 100 years. The availability of antitoxins, ethical issues around production, and risks involved in the use of animal derived serum products ...
Hans de Smit   +4 more
doaj   +1 more source

Bayesian estimation for the M/G/1 queue using a phase type approximation [PDF]

open access: yes, 2001
This article deals with Bayesian inference and prediction for M/G/1 queueing systems. The general service time density is approximated with a class of Erlang mixtures which are phase type distributions.
Ausín Olivera, María Concepción   +2 more
core   +1 more source

Rydberg-London Potential for Diatomic Molecules and Unbonded Atom Pairs

open access: yes, 2004
We propose and test a pair potential that is accurate at all relevant distances and simple enough for use in large-scale computer simulations. A combination of the Rydberg potential from spectroscopy and the London inverse-sixth-power energy, the ...
Axilrod   +22 more
core   +1 more source

Site-Specific Dual-Labeling of a VHH with a Chelator and a Photosensitizer for Nuclear Imaging and Targeted Photodynamic Therapy of EGFR-Positive Tumors

open access: yesCancers, 2021
Simple Summary Variable domains of heavy chain only antibodies are small proteins that can be used for tumor imaging and therapy upon conjugation of functional groups. As frequently used random conjugation techniques can decrease binding to the target of
Emma Renard   +8 more
semanticscholar   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

open access: yesiNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng   +3 more
wiley   +1 more source

Global analysis of VHHs framework regions with a structural alphabet [PDF]

open access: yesBiochimie, 2016
The VHHs are antigen-binding region/domain of camelid heavy chain antibodies (HCAb). They have many interesting biotechnological and biomedical properties due to their small size, high solubility and stability, and high affinity and specificity for their antigens. HCAb and classical IgGs are evolutionary related and share a common fold.
Floriane Noël   +2 more
openaire   +3 more sources

Two Epitope Regions Revealed in the Complex of IL-17A and Anti-IL-17A VHH Domain

open access: yesInternational Journal of Molecular Sciences, 2022
Interleukin-17 (IL-17) is a cytokine produced by the Th17 cells. It is involved in chronic inflammation in patients with autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and psoriasis.
O. Kostareva   +7 more
semanticscholar   +1 more source

Intrinsic and Water‐Triggered Hydrophilicity in Tween 20‐PDMS Composites for Dynamic and Long‐Term Wettability Control

open access: yesSmall, EarlyView.
A one‐step bulk integration of the surfactant Tween 20 into PDMS enables intrinsic and water‐triggered hydrophilicity. Combined molecular simulations and experiments reveal a dual mechanism where bound and mobile Tween 20 molecules cooperatively induce self‐activating, stretch‐tolerant, and long‐term wettability, supporting self‐driven liquid transport,
Haotian Cha   +8 more
wiley   +1 more source

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