Results 41 to 50 of about 54,904 (251)

FULLY AI-DRIVEN HUMANOID VHH PHAGE LIBRARY

Antibody Therapeutics, 2023
Abstract Background & Significance VHHs are small and stable fragments that have great potential as therapeutics due to their small size, stability, versatility, and potential for oral administration.
Zhao, Yangyang, Niu, Le, Pan, Xuemin, Ye, Xingda, Yu, Quan, Zhu, Yupeng, Chen, Yile, Sun, Zhiwu, Long, Yunfei, Li, Yi   +9 more
openaire   +1 more source

Development of potent and effective synthetic SARS-CoV-2 neutralizing nanobodies

mAbs, 2021
The respiratory virus responsible for coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected nearly every aspect of life worldwide, claiming the lives of over 3.9 million people globally, at the ...
Maxwell A. Stefan, Yooli K. Light, Jennifer L. Schwedler, Peter R. McIlroy, Colleen M. Courtney, Edwin A. Saada, Christine E. Thatcher, Ashlee M. Phillips, Feliza A. Bourguet, Catherine M. Mageeney, Summer A. McCloy, Nicole M. Collette, Oscar A. Negrete, Joseph S. Schoeniger, Dina R. Weilhammer, Brooke Harmon   +15 more
doaj   +1 more source

Design Digestion: work in progress [PDF]

, 2008
Enough of taste and mastication. It is time to look beyond the momentary, tasteful consumption of designed objects, in order to make account of the various meanings that are generated through their more drawn-out engagements.
Booth, Peter, Brassett, Jamie
core   +1 more source

Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies

Scientific Reports, 2018
Nucleolin arises as a relevant target for cancer therapy, as it is overexpressed at the surface of cancer and angiogenic endothelial cells thus enabling a dual cellular targeting strategy.
Sofia Romano, Vera Moura, Sérgio Simões, João Nuno Moreira, João Gonçalves   +4 more
doaj   +1 more source

Self-Assembling VHH-Elastin-Like Peptides for Photodynamic Nanomedicine [PDF]

Biomacromolecules, 2017
Recombinant llama heavy-chain antibody fragments (VHHs) are promising tools in the field of targeted nanomedicine. 7D12, a VHH against the epidermal growth factor receptor (EGFR) that is overexpressed in various cancers, has been evaluated as an effective cancer-targeting VHH in multiple studies.
Pille, J., van Lith, S.A.M., van Hest, J., van Hest, J., Leenders, W.P.J.   +4 more
openaire   +5 more sources

Developing drug-like single-domain antibodies (VHH) from in vitro libraries. [PDF]

MAbs
Erasmus MF, Teixeira AAR, Molina E, Rodriguez Carnero LA, Li J, Knight D, Di Niro R, Leal-Lopes C, Fanni A, Troell H, DeAguero A, Spector L, D'Angelo S, Ferrara F, Bradbury ARM.   +14 more
europepmc   +2 more sources

A Model of Russia's "Virtual Economy" [PDF]

, 2000
The Russian Economy has evolved into a hybrid form, a partially monetized quasi-market system that has been called the virtual economy. In the virtual economy, barter and non-monetary transactions play a key role in transferring value from the ...
Ericson, Richard E., Ickes, Barry W.
core   +1 more source

Contribution of CDR3 in characterization of camelid VHH and its aflatoxin B1-binding interaction

Food Chemistry Advances
The single variable domain of heavy chain (VHH) antibodies, owing to their unique properties, has gained attention in immunoassays. However, compared with macromolecule antigens, in the case of small molecule haptens, such as aflatoxin B1 (AFB1), the ...
Hina Mukhtar, Lan Ma, Qian Pang, Xiaohong Wang, Jia Wang   +4 more
doaj   +1 more source

An alpaca single-domain antibody (VHH) phage display library constructed by CDR shuffling provided high-affinity VHHs against desired protein antigens

International Immunology, 2022
Abstract Antigen-combining sites of the camelid heavy-chain antibody variable domain (VHH) are constructed by three complementarity-determining regions (CDR1, CDR2 and CDR3). We prepared cDNA using mRNA extracted from peripheral lymphocytes of alpacas that had been non-immunized or immunized with human serum albumin (HSA).
Narutoshi Tsukahara, Akikazu Murakami, Maiko Motohashi, Hiroshi Nakayama, Yoshiro Kondo, Yuji Ito, Takachika Azuma, Hidehiro Kishimoto   +7 more
openaire   +2 more sources

Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants

Frontiers in Immunology, 2022
Anti-COVID antibody therapeutics have been developed but not widely used due to their high cost and escape of neutralization from the emerging variants.
Qi Li, Fiachra Humphries, Roxie C. Girardin, Aaron Wallace, Monir Ejemel, Alla Amcheslavsky, Conor T. McMahon, Zachary A. Schiller, Zepei Ma, John Cruz, Alan P. Dupuis, Anne F. Payne, Arooma Maryam, Nese Kurt Yilmaz, Kathleen A. McDonough, Brian G. Pierce, Celia A. Schiffer, Andrew C. Kruse, Mark S. Klempner, Lisa A. Cavacini, Katherine A. Fitzgerald, Yang Wang   +21 more
doaj   +1 more source