Results 41 to 50 of about 57,494 (245)
Intracellular VHHs to monitor and modulate GPCR signaling
Frontiers in Endocrinology, 2022 Single-domain antibody fragments, also known as VHHs or nanobodies, have opened promising avenues in therapeutics and in exploration of intracellular processes. Because of their unique structural properties, they can reach cryptic regions in their cognate antigen.
Pauline Raynaud +9 more
openaire +5 more sources
Protein Expression and Purification, 2023 Antibody-mimetic drug conjugate (AMDC) is a cancer cell-targeted drug delivery system based on the non-covalent binding of mutated streptavidin and modified biotin, namely Cupid and Psyche. However, the development of AMDCs is hampered by difficulties in
Juri Sakata +21 more
semanticscholar +1 more source
Accelerating GPCR Drug Discovery With Conformation-Stabilizing VHHs
Frontiers in Molecular Biosciences, 2022 The human genome encodes 850 G protein-coupled receptors (GPCRs), half of which are considered potential drug targets. GPCRs transduce extracellular stimuli into a plethora of vital physiological processes. Consequently, GPCRs are an attractive drug target class.
Toon Laeremans +10 more
openaire +3 more sources
mAbs, 2023 As small and stable high-affinity antigen binders, VHHs boast attractive characteristics both for therapeutic use in various disease indications, and as versatile reagents in research and diagnostics.
Loes van Schie +15 more
semanticscholar +1 more source
Discrete analysis of camelid variable domains: sequences, structures, and in-silico structure prediction [PDF]
PeerJ, 2020 Antigen binding by antibodies requires precise orientation of the complementarity- determining region (CDR) loops in the variable domain to establish the correct contact surface.
Akhila Melarkode Vattekatte +9 more
doaj +2 more sources
DISCOVERY OF NOVEL ANTI-SERUM ALBUMIN VHH AS A BUILDING BLOCK FOR PK PROLONGATION
Antibody Therapeutics, 2023 Background The serum half-life of endogenous albumin is approximately 19 days in humans and 1.5-2.5 days in rodents. This extended half-life in vivo is primarily due to effective recycling upon internalization mediated by the neonatal Fc receptor (FcRn).
Yunying Chen +5 more
semanticscholar +1 more source
Frontiers in Immunology, 2017 The activity of tumor necrosis factor (TNF), a cytokine involved in inflammatory pathologies, can be inhibited by antibodies or trap molecules. Herein, llama-derived variable heavy-chain domains of heavy-chain antibody (VHH, also called Nanobodies™) were
Els Beirnaert +14 more
doaj +1 more source
Development of VHH antibodies against dengue virus type 2 NS1 and comparison with monoclonal antibodies for use in immunological diagnosis. [PDF]
PLoS ONE, 2014 The possibility of using variable domain heavy-chain antibodies (VHH antibodies) as diagnostic tools for dengue virus (DENV) type 2 NS1 protein was investigated and compared with the use of conventional monoclonal antibodies.
Aneela Fatima +7 more
doaj +1 more source
VHHs as tools for therapeutic protein delivery to the central nervous system
Fluids and Barriers of the CNS, 2022 Background The blood brain barrier (BBB) limits the therapeutic perspective for central nervous system (CNS) disorders. Previously we found an anti-mouse transferrin receptor (TfR) VHH (Nb62) that was able to deliver a biologically active neuropeptide ...
Yessica Wouters +5 more
doaj +1 more source
On the Interaction of Monetary and Fiscal Policy [PDF]
, 2003 In this paper we review some fundamental issues that have been identified by macroeconomists in discussing the co-ordination of monetary and fiscal policy.
Chadha, Jagjit S., Nolan, Charles
core +1 more source