Results 71 to 80 of about 54,904 (251)
Nanobody and Its Therapeutic Applications
Journal of Mazandaran University of Medical Sciences, 2018 Background and purpose: Monoclonal antibodies market has grown since approval of Muromonab-CD3 (trade name Orthoclone OKT3) in 1986 as immuno- suppressor.
Maryam Darvish
doaj
Frontiers in Plant Science, 2021 Chimeric fusion proteins comprising a single domain antibody (VHH) fused to a crystallizable fragment (Fc) of an immunoglobulin are modular glycoproteins that are becoming increasingly in demand because of their value as diagnostics, research reagents ...
Adam Chin-Fatt +3 more
doaj +1 more source
Arthritis &Rheumatology, Accepted Article.Objective The spontaneous K/BxN mouse model of rheumatoid arthritis has been used extensively to study chronic inflammation, contribution of immune cells, and the primordial role of autoreactive antibodies in disease initiation and severity. Only the ubiquitous enzyme glucose‐6‐phosphate isomerase (GPI) is the target of IgG autoantibodies secreted by ...
Thibault Vanhoucke +8 more
wiley +1 more source
Anti-VP6 VHH: An Experimental Treatment for Rotavirus A-Associated Disease. [PDF]
PLoS ONE, 2016 Species A Rotaviruses (RVA) remain a leading cause of mortality in children under 5 years of age. Current treatment options are limited. We assessed the efficacy of two VP6-specific llama-derived heavy chain antibody fragments (VHH) -2KD1 and 3B2- as an ...
Lucía Maffey +4 more
doaj +1 more source
Chimera X Interface to Enhance Understanding in Biochemistry and Immunology
Biochemistry and Molecular Biology Education, EarlyView.ABSTRACT Proteins are essential in biological systems, acting in transport, catalysis, and immune defense processes. However, these biomolecules' structural and functional complexity makes teaching and understanding these topics challenging. To address this difficulty, this study aimed to develop tutorials that facilitate learning and teaching about ...
Dalpiaz Giovana +4 more
wiley +1 more source
Global analysis of VHHs framework regions with a structural alphabet [PDF]
Biochimie, 2016 The VHHs are antigen-binding region/domain of camelid heavy chain antibodies (HCAb). They have many interesting biotechnological and biomedical properties due to their small size, high solubility and stability, and high affinity and specificity for their antigens. HCAb and classical IgGs are evolutionary related and share a common fold.
Floriane Noël +2 more
openaire +3 more sources
Chemistry – A European Journal, EarlyView.The tCAP(N3) reagent, featuring a stable and self‐activating precursor, enables site‐specific conjugation of native IgGs. This Fc‐affinity peptide approach selectively transfers an Ac‐Lys(N3)‐Gly‐Gly payload to Lys248, producing divalently azidated antibody while preserving its biological function.
Hiroko Kawakami +12 more
wiley +1 more source
Overexpression, Purification, Characterization, and Pathogenicity of Vibrio harveyi Hemolysin VHH [PDF]
Infection and Immunity, 2006 ABSTRACT Vibrio harveyi VHH hemolysin is a putative pathogenicity factor in fish. In this study, the hemolysin gene vhhA was overexpressed in Escherichia coli , and the purified VHH was characterized with regard to pH and temperature profiles, phospholipase activity ...
Zhong, Yingbin +6 more
openaire +4 more sources
Micropatterned Surfaces with Unidirectional Wetting Properties for Liquid Transport
Small Structures, EarlyView.Micropatterned surfaces that guide droplets in a single direction are gaining attention for their role in liquid transport. This review explores how surface designs enable such behavior, from gravity‐driven flow to stimulus‐responsive movement. It also discusses fabrication techniques, design challenges, and emerging strategies to advance directional ...
Elham Lori Zoudani +5 more
wiley +1 more source
mAbs, 2020 Here, we report the characterization of a VHH-derived IgG-like bi- and trispecific antibody platform that essentially relies on the replacement of the VH and VL regions of a conventional antibody by two independently functioning VHH domains. Consequently,
Lukas Pekar +6 more
doaj +1 more source