Results 91 to 100 of about 900,097 (207)

Immunohistochemical expression of intermediate filaments in diagnostics of diffuse gliomas.

Medičnì Perspektivi, 2017
Intermediate filament proteins play an important role in maintaining a stable shape, as well as the possible movement of cells, including neoplastic cells.
T. V. Shynkarenko
doaj   +1 more source

Chemopreventive Effect of Bitter Melon (Momordica charantia) Juice on Pancreatic Carcinogenesis in LSL‐KrasG12D/+; p48Cre/+ Mice

Molecular Carcinogenesis, EarlyView.
ABSTRACT Herein, using the LSL‐KrasG12D/+; p48Cre/+ transgenic mouse model [that recapitulates the full spectrum of human disease, progressing from early pancreatic intraepithelial neoplasia lesions to invasive pancreatic ductal adenocarcinoma (PDAC)], we determined the chemopreventive effect of long‐term (chronic) administration of Bitter Melon Juice (
Lakshmi Sai Pratyusha Bugata, Deepanshi Dhar, Rama Kant, Robin Kumar, Md. Imtiazul Kabir, Chapla Agarwal, Rajesh Agarwal, Komal Raina   +7 more
wiley   +1 more source

Intermediate Filaments of the Vimentin and Prekeratin Type in Human Epidermis

Journal of Investigative Dermatology, 1983
Monospecific antibodies to intermediate filaments of mesenchymally derived vimentin, applied to frozen sections of human skin, specifically stained dendritic basal and suprabasal cells. Cellular morphology, distribution, reaction pattern with anti-HLA-DR in serial sections, and OKT6 in double-staining procedures identified these cells as melanocytes ...
Mahrle, Gustav, Bolling, Regine, Osborn, Mary, Weber, Klaus   +3 more
openaire   +2 more sources

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Vimentin Phosphorylation Is Required for Normal Cell Division of Immature Astrocytes

Cells, 2019
Vimentin (VIM) is an intermediate filament (nanofilament) protein expressed in multiple cell types, including astrocytes. Mice with VIM mutations of serine sites phosphorylated during mitosis (VIMSA/SA) show cytokinetic failure in fibroblasts and lens ...
Yolanda de Pablo, Pavel Marasek, Andrea Pozo-Rodrigálvarez, Ulrika Wilhelmsson, Masaki Inagaki, Marcela Pekna, Milos Pekny   +6 more
doaj   +1 more source

Diacerein Disrupts Testicular Homeostasis: The Essential Role of Basal Cytokines in Maintaining Sertoli Cell Integrity and the Immune Microenvironment

Andrology, EarlyView.
ABSTRACT Background Pro‐inflammatory cytokines, TNF and IL‐1B, are essential for testicular homeostasis. Diacerein, an anti‐inflammatory drug, inhibits these cytokines, impairing M2 macrophages and Leydig cells (LCs). However, its impact on Sertoli cells (SCs) and M1 (CD68) macrophages remains unknown.
Elide Loise Freitas de Jesus, André Acácio Souza da Silva, Olumide Stephen Akinsomisoye, Erick J. R. Silva, Paulo Sérgio Cerri, Salmo Azambuja de Oliveira, Estela Sasso‐Cerri   +6 more
wiley   +1 more source

Mechanical Properties of Vimentin Intermediate Filament Networks [PDF]

Biophysical Journal, 2014
One marker of mesenchymal cells is the expression of vimentin intermediate filament (VIF) proteins, which assemble into networks. The cytoskeleton is typically comprised of these intermediate filament networks, actin, and microtubules. While some aspects of VIF networks have been characterized in bulk, their mechanical properties in situ have not been ...
Wu, Huayin, Jensen, Mikkel, Guo, Ming, Weitz, David A.   +3 more
openaire   +1 more source

Downregulation of KRTAP2‐3 Suppresses Proliferation and Tumor Formation of Oral Cancer Cells via Inactivation of KRAS Signals

Cancer Science, EarlyView.
KRTAP2‐3 drives OSCC progression by sustaining both mesenchymal and proliferative properties through KRAS signaling. Loss of KRTAP2‐3 induces MET, suppresses KRAS pathway activation, and markedly reduces tumor cell proiferation and tumor formation as illustarted in Figure.
Qianqian Miao, Zhijun Huang, Kazuki Takahashi, Haruka Ibi, Kohei Miyazono, Katarzyna A. Podyma‐Inoue, Tetsuro Watabe   +6 more
wiley   +1 more source

Cultured Human Melanocytes Express the Intermediate Filament Vimentin

Journal of Investigative Dermatology, 1993
Human melanocytes are neural crest-derived cells that synthesize the pigment melanin. These cells migrate from a central location to the dermal-epidermal junction early in gestation and situate themselves between keratinocytes of the basal layer of the epidermis, extending thin dendritic processes upwards into the epidermis.
Si, Seong Pan, Tsou, Hui C, Lee, Xinhua, Peacocke, Monica   +3 more
openaire   +2 more sources

Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics

Neurobiology of Disease, 2006
Early onset torsion dystonia is a movement disorder inherited as an autosomal dominant syndrome with reduced penetrance. Symptoms appear to result from altered neuronal circuitry within the brain with no evidence of neuronal loss.
Jeffrey W. Hewett, Juan Zeng, Brian P. Niland, D. Cristopher Bragg, Xandra O. Breakefield   +4 more
doaj   +1 more source