Results 111 to 120 of about 900,097 (207)

Type III intermediate filaments as novel CoAlation targets

Redox Report
Objectives Type III intermediate filaments, such as vimentin, GFAP, and desmin, are involved in cell mechanics, signaling, and stress responses, and are tightly regulated by posttranslational modifications (PTMs). The monomers of these proteins possess a
Nuria Goya-Iglesias, Bess Yi Kun Yu, Ivan Gout, Dolores Pérez-Sala   +3 more
doaj   +1 more source

Clinical and Molecular Features of BAP1‐Mutated Meningiomas: Case Series

Molecular Carcinogenesis, Volume 65, Issue 10, Page 1343-1350, October 2026.
ABSTRACT BRCA1‐associated protein 1 (BAP1)‐deficient meningiomas represent a clinically and molecularly distinct subgroup with variable histology and aggressive behavior that may not be fully captured by current grading criteria. The clinical spectrum of BAP1 alterations in meningiomas, including both somatic and germline contexts, remains incompletely
Ivan Pradilla, Rasha Alfattal, Susan L. McGovern, Shaan M. Raza, Franco DeMonte, Leomar Y. Ballester, Chirag B. Patel, Carlos Kamiya‐Matsuoka   +7 more
wiley   +1 more source

Regulation of vimentin intermediate filaments in endothelial cells by hypoxia

American Journal of Physiology-Cell Physiology, 2010
Hypoxia triggers responses in endothelial cells that play roles in many conditions including high-altitude pulmonary edema and tumor angiogenesis. Signaling pathways activated by hypoxia modify cytoskeletal and contractile proteins and alter the biomechanical properties of endothelial cells.
Tiegang, Liu, Oscar E, Guevara, Rod R, Warburton, Nicholas S, Hill, Matthias, Gaestel, Usamah S, Kayyali   +5 more
openaire   +3 more sources

Oxidative stress elicits the remodeling of vimentin filaments into biomolecular condensates

Redox Biology
The intermediate filament protein vimentin performs an essential role in cytoskeletal interplay and dynamics, mechanosensing and cellular stress responses. In pathology, vimentin is a key player in tumorigenesis, fibrosis and infection.
Paula Martínez-Cenalmor, Alma E. Martínez, Diego Moneo-Corcuera, Patricia González-Jiménez, Dolores Pérez-Sala   +4 more
doaj   +1 more source

Vimentin-dependent utilization of LDL-cholesterol in human adrenal tumor cells is not associated with the level of expression of apoE, sterol carrier protein-2, or caveolin

Journal of Lipid Research, 1999
SW-13 adrenal tumor cells that lack detectable intermediate filaments (IF-free) exhibit an impaired capacity to esterify lipoprotein-derived cholesterol compared with cells that contain vimentin filaments.
Tricia A. Holwell, Susan C. Schweitzer, Mary E. Reyland, Robert M. Evansk   +3 more
doaj   +1 more source

The Sleeping Giant: Metabolism and Autophagy in the Generation and Survival of Dormant Polyploid Giant Cancer Cells

MedComm, Volume 7, Issue 10, October 2026.
Polyploid giant cancer cells (PGCCs) arise in response to stress and play a critical role in therapy resistance and tumor dormancy. These cells can evade conventional treatments and later contribute to cancer relapse by generating progeny through nonmitotic, amitotic mechanisms.
Silvia Guil‐Luna, María Teresa Sánchez‐Montero, Alejandra Díaz‐Chacón, Antonio Rodríguez‐Ariza   +3 more
wiley   +1 more source

Efeito do 3,5,3' -triiodo-l-tironina nas proteínas dos filamentos intermediários de testículos de ratos durante o desenvolvimento sexual [PDF]

, 2002
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Farmácia.As células de Sertoli têm um importante papel no desenvolvimento e na manutenção da espermatogênese em testículos de ...
Zamoner, Ariane
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, Volume 20, Issue 9, Page 2243-2261, September 2026.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Vimentin Intermediate Filaments Mediate Cell Morphology on Viscoelastic Substrates

The ability of cells to take and change shape is a fundamental feature underlying development, wound repair, and tissue maintenance. Central to this process is physical and signaling interactions between the three cytoskeletal polymeric networks: F-actin,
Maxx Swoger (11920363), Elisabeth E. Charrier (11920369), Sarthak Gupta (11920366), Heidi Hehnly (690846), Michael Bates (231171), Alison E. Patteson (11920372)   +5 more
core   +3 more sources

Vimentin networks at high strains

Physical Review Research
The cytoskeleton is crucial in maintaining cell shape and structural integrity. It consists of three types of filaments—actin filaments, microtubules, and intermediate filaments (IFs).
Shanay Zafari, Sophia Schirra, Raffaele Mendozza, Sascha Lambert, Kristian A. T. Pajanonot, Pallavi Kumari, Peter Sollich, Sarah Köster   +7 more
doaj   +1 more source