Results 1 to 10 of about 1,846,216 (386)
Membrane Rafts: Portals for Viral Entry [PDF]
Frontiers in Microbiology, 2021 Membrane rafts are dynamic, small (10–200 nm) domains enriched with cholesterol and sphingolipids that compartmentalize cellular processes. Rafts participate in roles essential to the lifecycle of different viral families including virus entry, assembly ...
Inés Ripa +7 more
doaj +6 more sources
An aquatic virus exploits the IL6-STAT3-HSP90 signaling axis to promote viral entry.
PLoS Pathogens, 2023 Viral seasonality in the aquaculture industry is an important scientific issue for decades. While the molecular mechanisms underpinning the temperature-dependent pathogenesis of aquatic viral diseases remain largely unknown.
Guoli Hou +13 more
doaj +4 more sources
SLC38A9 regulates SARS-CoV-2 viral entry [PDF]
iScienceSummary: SARS-CoV-2 viral entry into host cells depends on the cleavage of spike (S) protein into S1 and S2 proteins. Such proteolytic cleavage by furin results in the exposure of a multibasic motif on S1, which is critical for SARS-CoV-2 viral infection
Gaurav Datta +4 more
doaj +4 more sources
The Role of Orthobunyavirus Glycoprotein Gc in the Viral Life Cycle: From Viral Entry to Egress [PDF]
MoleculesOrthobunyavirus refers to the virus members within the Genus Orthobunyavirus, which is the largest virus genus in the Family Peribunyaviridae and even Class Bunyaviricetes.
Han Gao +8 more
doaj +4 more sources
Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration
eLife, 2020 The Spike protein of SARS-CoV-2, its receptor-binding domain (RBD), and its primary receptor ACE2 are extensively glycosylated. The impact of this post-translational modification on viral entry is yet unestablished.
Qi Yang +8 more
doaj +2 more sources
Viruses, 2020 Viral entry is the first stage in the virus replication cycle and, for enveloped viruses, is mediated by virally encoded glycoproteins. Viral glycoproteins have different receptor affinities and triggering mechanisms.
Maria Fernanda Lay Mendoza +4 more
doaj +2 more sources
mGem: The complexity of viral entry—one virus, many receptors [PDF]
mBioBinding to cellular receptors initiates viral replication and dictates sites in the host infected by the virus. As illustrated by mammalian orthoreovirus (reovirus), viruses can bind several types of receptors using distinct capsid components to ...
Terence S. Dermody, Danica M. Sutherland
doaj +2 more sources
Hepatitis C viral entry inhibitors prolong viral suppression by replication inhibitors in persistently-infected Huh7 cultures. [PDF]
PLoS ONE, 2013 Efforts to treat HCV patients are focused on developing antiviral combinations that lead to the eradication of infection. Thus, it is important to identify optimal combinations from the various viral inhibitor classes.
Caroline O Bush +3 more
doaj +3 more sources
Influenza hemagglutinin drives viral entry via two sequential intramembrane mechanisms
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Viral proteins that accomplish membrane fusion between the virus and a host cell do two things: draw virus and host membranes together and act within these membranes to induce fusion.
Anna Pabis +2 more
openalex +3 more sources
Hepatitis C virus cell-cell transmission and resistance to direct-acting antiviral agents [PDF]
, 2014 Hepatitis C virus (HCV) is transmitted between hepatocytes via classical cell entry but also uses direct cell-cell transfer to infect neighboring hepatocytes.
A Owsianka +72 more
core +20 more sources