Results 21 to 30 of about 1,846,216 (386)

Acid-dependent viral entry

Virus Research, 2012
Virus infection of host cells requires that entry into the cell results in efficient genome release leading to translation and replication. These initial steps revolving around the entry and genomic release processes are crucial for viral progeny generation.
Angela, Vázquez-Calvo, Juan-Carlos, Saiz, Kenneth C, McCullough, Francisco, Sobrino, Miguel A, Martín-Acebes   +4 more
  +7 more sources

The Process of Filopodia Induction during HPV Infection

Viruses, 2022
Human Papillomavirus 16 (HPV16) infects mucosal and epithelial cells and has been identified as a high-risk HPV type that is an etiologic agent of human cancers.
Alyssa Biondo, Patricio I. Meneses
doaj   +1 more source

Generation of SARS-CoV-2 Spike Pseudotyped Virus for Viral Entry and Neutralization Assays: A 1-Week Protocol

Frontiers in Cardiovascular Medicine, 2021
The COVID-19 pandemic caused by the SARS-CoV-2 coronavirus requires reliable assays for studying viral entry mechanisms which remains poorly understood.
J. M. Cóndor Capcha, Guerline Lambert, Derek M. Dykxhoorn, A. Salerno, J. Hare, M. Whitt, S. Pahwa, D. Jayaweera, L. Shehadeh   +8 more
semanticscholar   +1 more source

SNX10 enhances HCoV-OC43 infection by facilitating viral entry and inhibiting virus-triggered autophagy. [PDF]

Virol Sin
Li H, Guo H, Rong B, Li H, Wu W, Yang C, Liu S.   +6 more
europepmc   +2 more sources

Disruption of disulfides within RBD of SARS‐CoV‐2 spike protein prevents fusion and represents a target for viral entry inhibition by registered drugs

The FASEB Journal, 2021
The SARS‐CoV‐2 pandemic imposed a large burden on health and society. Therapeutics targeting different components and processes of the viral infection replication cycle are being investigated, particularly to repurpose already approved drugs.
Mateja Manček-Keber, Iva Hafner-Bratkovič, D. Lainšček, M. Benčina, Tea Govednik, Sara Orehek, Tjaša Plaper, Vid Jazbec, Valter Bergant, Vincent Grass, A. Pichlmair, R. Jerala   +11 more
semanticscholar   +1 more source

Trypsin enhances SARS-CoV-2 infection by facilitating viral entry

Archives of Virology, 2021
Coronaviruses infect cells by cytoplasmic or endosomal membrane fusion, driven by the spike (S) protein, which must be primed by proteolytic cleavage at the S1/S2 furin cleavage site (FCS) and the S2′ site by cellular proteases.
Yeeun Kim, Guehwan Jang, D. Lee, Na-Na Kim, Jeong-Won Seon, Young-hoan Kim, Changhee Lee   +6 more
semanticscholar   +1 more source

Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry

Viruses, 2021
Innate immunity during acute infection plays a critical role in the disease severity of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), and is likely to contribute to COVID-19 disease outcomes.
Chuan Xu, Annie Wang, M. Marin, W. Honnen, Santhamani Ramasamy, E. Porter, S. Subbian, A. Pinter, G. Melikyan, Wuyuan Lu, Theresa L. Chang   +10 more
semanticscholar   +1 more source

Diazadispiroalkane Derivatives Are New Viral Entry Inhibitors [PDF]

Antimicrobial Agents and Chemotherapy, 2021
Herpesviruses are widespread and can cause serious illness. Many currently available antiviral drugs have limited effects, result in rapid development of resistance, and often exhibit dose-dependent toxicity.
Rebekka Adfeldt, Janna Schmitz, Barbara Kropff, Marco Thomas, Natalia Monakhova, Julia E. Hölper, Barbara G. Klupp, Thomas C. Mettenleiter, Vadim Makarov, Elke Bogner   +9 more
openaire   +2 more sources

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells

bioRxiv, 2020
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue pathology.
C. Muus, Malte D. Luecken, Gökçen Eraslan, Avinash Waghray, Graham S. Heimberg, L. Sikkema, Yoshihiko Kobayashi, E. D. Vaishnav, Ayshwarya Subramanian, Christopher Smilie, K. Jagadeesh, E. Duong, Evgenij Fiskin, E. Triglia, M. Ansari, Peiwen Cai, B. Lin, J. Buchanan, Sijia Chen, J. Shu, Adam L. Haber, Hattie Chung, Daniel T. Montoro, T. Adams, H. Aliee, J. Samuel, Allon Zaneta Andrusivova, I. Angelidis, O. Ashenberg, K. Bassler, C. Bécavin, Inbal Benhar, J. Bergenstråhle, L. Bergenstråhle, L. Bolt, Emelie Braun, L. T. Bui, M. Chaffin, E. Chichelnitskiy, Joshua Chiou, T. Conlon, Michael S. Cuoco, M. Deprez, David S. Fischer, A. Gillich, Joshua Gould, M. Guo, A. Gutierrez, A. Habermann, T. Harvey, Peng He, Xiaomeng Hou, Lijuan Hu, Alok Jaiswal, P. Jiang, Theodoros Kapellos, Christin S Kuo, L. Larsson, Michael A. Leney-Greene Kyungtae Lim, Monika Litviňuková, Ji Lu, H. Maatz, E. Madissoon, L. Mamanova, Kasidet Manakongtreecheep, C. Marquette, Ian M Mbano, A. Mcadams, Ross J. Metzger, Ahmad N. Nabhan, Sarah K Nyquist, J. Ordovas-Montañes, L. Penland, Olivier B. Poirion, S. Poli, Cancan Qi, D. Reichart, I. Rosas, J. Schupp, Rahul Sinha, R. Sit, Kamil Slowikowski, M. Slyper, N. Smith, A. Sountoulidis, M. Strunz, Dawei Sun, Carlos Talavera-López, Peng Tan, J. Tantivit, K. Travaglini, N. Tucker, K. Vernon, M. Wadsworth, J. Waldmann, Xiuting Wang, Wenjun Yan, William Zhao, Carly G. K. Ziegler   +98 more
semanticscholar   +1 more source

Targeting the viral‐entry facilitators of SARS‐CoV‐2 as a therapeutic strategy in COVID‐19

Journal of Medical Virology, 2021
Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) is the causative agent of coronavirus disease 2019 (COVID‐19) infection, which has emerged as a global pandemic causing serious concerns.
Shibi Muralidar, Gayathri Gopal, S. V. Ambi   +2 more
semanticscholar   +1 more source