Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry [PDF]
The FEBS Journal, 2009 Herpes simplex virus type‐1 and type‐2 are highly prevalent human pathogens causing life‐long infections. The process of infection begins when the virions bind heparan sulfate moieties present on host cell surfaces. This initial attachment then triggers a cascade of molecular interactions involving multiple viral and host cell proteins and receptors ...
Jihan, Akhtar, Deepak, Shukla
openaire +2 more sources
Frontiers in Medicine, 2022 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a viral pathogen causing life-threatening diseases in humans. Interaction between the spike protein of SARS-CoV-2 and angiotensin-converting enzyme 2 (ACE2) is a potential factor in the ...
Manas Ranjan Praharaj +14 more
doaj +1 more source
Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry
bioRxiv, 2021 Coagulopathy is recognized as a significant aspect of morbidity in COVID-19 patients. The clotting cascade is propagated by a series of proteases, including factor Xa and thrombin.
Edward R. Kastenhuber +9 more
semanticscholar +1 more source
Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. [PDF]
, 2011 Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) emerged as the causal agent of an endemic atypical pneumonia, infecting thousands of people worldwide.
Agudelo, Juliet +10 more
core +1 more source
NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry
Science China Life Sciences, 2021 Viruses utilize cellular lipids and manipulate host lipid metabolism to ensure their replication and spread. Therefore, the identification of lipids and metabolic pathways that are suitable targets for antiviral development is crucial. Using a library of
Guoli Li +8 more
semanticscholar +1 more source
Caveolin-1 associated adenovirus entry into human corneal cells. [PDF]
PLoS ONE, 2013 The cellular entry of viruses represents a critical area of study, not only for viral tropism, but also because viral entry dictates the nature of the immune response elicited upon infection.
Mohammad A Yousuf +7 more
doaj +1 more source
Viral entry and translation in brain endothelia provoke influenza-associated encephalopathy. [PDF]
Acta NeuropatholKimura-Ohba S +10 more
europepmc +3 more sources
SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation
bioRxiv, 2020 Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane fusion events caused by the same machinery that underlies viral entry.
David W. Sanders +18 more
semanticscholar +1 more source
Sialic acid-Dependent Binding and Viral Entry of SARS-CoV-2
bioRxiv, 2021 Emerging evidence suggests that host glycans influence infection by SARS-CoV-2. Here, we reveal that the receptor-binding domain (RBD) of the spike (S)-protein on SARS-CoV-2 recognizes oligosaccharides containing sialic acid (SA), with preference for the
Linh Nguyen +20 more
semanticscholar +1 more source
Biochemical prevention and treatment of viral infections – A new paradigm in medicine for infectious diseases [PDF]
, 2004 For two centuries, vaccination has been the dominating approach to develop prophylaxis against viral infections through immunological prevention. However, vaccines are not always possible to make, are ineffective for many viral infections, and also carry
Fang, Fang, Le Calvez, Hervé, Yu, Mang
core +3 more sources