Complex interplay of kinetic factors governs the synergistic properties of HIV-1 entry inhibitors. [PDF]
, 2017 The homotrimeric HIV-1 envelope glycoprotein (Env) undergoes receptor-triggered structural changes that mediate viral entry through membrane fusion. This process is inhibited by chemokine receptor antagonists (CoRAs) that block Env-receptor interactions ...
Ahn, Koree W., Root, Michael J.
core +2 more sources
PLoS Pathogens, 2021 Filoviruses, such as the Ebola virus (EBOV) and Marburg virus (MARV), are causative agents of sporadic outbreaks of hemorrhagic fevers in humans. To infect cells, filoviruses are internalized via macropinocytosis and traffic through the endosomal pathway
Corina M Stewart +10 more
doaj +1 more source
Association between disruption of CD4 receptor dimerization and increased human immunodeficiency virus type 1 entry [PDF]
, 2006 Affiliation: Département de microbiologie et immunologie, Faculté de médecine, Université de Montréal & Institut de Recherches Cliniques de MontréalBACKGROUND:Human immunodeficiency virus (HIV) enters target cells by a membrane fusion process that ...
Bourgeois, Rachel +3 more
core +3 more sources
Mapping the phosphoproteome of influenza A and B viruses by mass spectrometry [PDF]
, 2012 Protein phosphorylation is a common post-translational modification in eukaryotic cells and has a wide range of functional effects. Here, we used mass spectrometry to search for phosphorylated residues in all the proteins of influenza A and B viruses ...
Denham, Eleanor M. +8 more
core +3 more sources
Understanding the process of envelope glycoprotein incorporation into virions in simian and feline immunodeficiency viruses [PDF]
, 2014 The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting with specific receptors present at the cell surface, thereby determining viral tropism and pathogenesis.
Affranchino, Jose Luis +1 more
core +4 more sources
Non-viral approaches to gene therapy [PDF]
, 1993 Several advances in non-viral gene transfer technology have been reported over the past year. Cationic lipids have been successfully used to deliver genes in vivo, providing a clear alternative to recombinant viruses.
Behr +44 more
core +1 more source
Dissecting virus entry: replication-independent analysis of virus binding, internalization, and penetration using minimal complementation of β-galactosidase. [PDF]
PLoS ONE, 2014 Studies of viral entry into host cells often rely on the detection of post-entry parameters, such as viral replication or the expression of a reporter gene, rather than on measuring entry per se. The lack of assays to easily detect the different steps of
Christine Burkard +6 more
doaj +1 more source
Measuring the force ejecting DNA from phage [PDF]
, 2004 We discuss how a balance can be established between the force acting to eject DNA from viral capsids and the force resisting its entry into a colloidal suspension which mimics the host cell cytoplasm.
Castelnovo, M. +3 more
core +1 more source
Therapeutic development targeting host heparan sulfate proteoglycan in SARS-CoV-2 infection
Frontiers in MedicineThe global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an urgent need for effective therapeutic options.
Qi Zhang +3 more
doaj +1 more source
Structural understanding of SARS-CoV-2 virus entry to host cells
Frontiers in Molecular Biosciences, 2023 Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major global health concern associated with millions of fatalities worldwide.
Kim Le +7 more
doaj +1 more source