Results 41 to 50 of about 484,497 (156)

Building a mechanistic mathematical model of hepatitis C virus entry.

PLoS Computational Biology, 2019
The mechanism by which hepatitis C virus (HCV) gains entry into cells is a complex one, involving a broad range of host proteins. Entry is a critical phase of the viral lifecycle, and a potential target for therapeutic or vaccine-mediated intervention ...
Mphatso Kalemera, Dilyana Mincheva, Joe Grove, Christopher J R Illingworth   +3 more
doaj   +1 more source

Antibody-Dependent Dengue Virus Entry Modulates Cell Intrinsic Responses for Enhanced Infection

mSphere, 2019
Dengue is caused by infection with any one of four dengue viruses (DENV); the risk of severe disease appears to be enhanced by the cross-reactive or subneutralizing levels of antibody from a prior DENV infection.
Candice Y. Y. Chan, John Zhong Heng Low, Esther Shuyi Gan, Eugenia Ziying Ong, Summer Li-Xin Zhang, Hwee Cheng Tan, Xiaoran Chai, Sujoy Ghosh, Eng Eong Ooi, Kuan Rong Chan   +9 more
doaj   +1 more source

The Role of L-Selectin in HIV Infection

Frontiers in Microbiology, 2021
HIV envelope glycoprotein is the most heavily glycosylated viral protein complex identified with over 20 glycans on its surface. This glycan canopy is thought to primarily shield the virus from host immune recognition as glycans are poor immunogens in ...
Jason Segura, Biao He, Joanna Ireland, Zhongcheng Zou, Thomas Shen, Gwynne Roth, Peter D. Sun   +6 more
doaj   +1 more source

Role of Ezrin Phosphorylation in HIV-1 Replication

Frontiers in Microbiology, 2018
Host-cell expression of the ezrin protein is required for CXCR4 (X4)-tropic HIV-1 infection. Ezrin function is regulated by phosphorylation at threonine-567. This study investigates the role of ezrin phosphorylation in HIV-1 infection and virion release.
Haruka Kamiyama, Haruka Kamiyama, Mai Izumida, Mai Izumida, Yuria Umemura, Hideki Hayashi, Hideki Hayashi, Toshifumi Matsuyama, Toshifumi Matsuyama, Yoshinao Kubo, Yoshinao Kubo, Yoshinao Kubo   +11 more
doaj   +1 more source

Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice [PDF]

, 2015
Objective: Direct-acting antivirals (DAAs) inhibit hepatitis C virus (HCV) infection by targeting viral proteins that play essential roles in the replication process. However, selection of resistance-associated variants (RAVs) during DAA therapy has been
Ball, Jonathan K., Baumert, Thomas, Bhuju, Sabin, Brown, Richard J.P., Cortese, Riccardo, Doerrbecker, Juliane, Farhoudi, Ali, Geffers, Robert, Leroux-Roels, Geert, McClure, C. Patrick, Mesalam, Ahmed Atef, Meuleman, Philip, Nicosia, Alfredo, Pietschmann, Thomas, Troise, Fulvia, Van Den Eede, Naomi, Vercauteren, Koen, Verhoye, Lieven   +17 more
core   +4 more sources

Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection. [PDF]

, 2018
Innate immune cells quickly infiltrate the site of pathogen entry and not only stave off infection but also initiate antigen presentation and promote adaptive immunity.
A Gladiator, A Ray, AC Patera, AD Joshi, AK Furuya, AM Owyang, AV Ivanov, AY Wen, BC Xu, C Zhao, CE Andoniou, CO Simon, CR Crowe, CW Lio, D Burdette, EH Kobayashi, GJ Bancroft, GM DeNicola, H Kato, H Kawasaki, HS Zhang, HY Cho, J Bystrom, J Lee, JL Bowen, JM Lee, K Tabeta, KA Daniels, KJ Livak, KL Hokeness, KL Hokeness, KM Hsu, LR Johnson, M Boeckh, M Wagner, MA Stacey, MC Cheeran, MJ Crane, MJ Kesic, MJ Reddehase, MK Arababadi, N Nagai, NM Reddy, P Balanescu, P Ye, Q Ma, R Guabiraba, R Saddawi-Konefka, R Seelige, R Seelige, RK Thimmulappa, RL Wheat, S Jonjic, S Jordan, S Kohyama, S Mamo, S Schaedler, S Sell, SL Deshmane, SL Gaffen, SP Francis, T O’Sullivan, T Starnes, TP Salazar-Mather, V Ramirez-Carrozzi, VA Rathinam, W Hou, W Hou, X Song, X Wang, Y Iwakura, Y Shinkai, Y Yageta, Y Zhang, YL Cheng, Z Huang   +75 more
core   +3 more sources

Cholesterol-rich lipid rafts mediate endocytosis as a common pathway for respiratory syncytial virus entry into different host cells

Microbiology Spectrum
The entry of respiratory syncytial virus (RSV) into host cells is a multifaceted process involving viral adsorption, interaction of viral glycoproteins with cellular receptors, and utilization of various invasion pathways. Despite these complexities, our
Anqi Zhou, Bao Xue, Jiayi Zhong, Junjun Liu, Ran Peng, Fan Wang, Yuan Zhou, Jielin Tang, Qi Yang, Xinwen Chen   +9 more
doaj   +1 more source

LRRC15 inhibits SARS-CoV-2 cellular entry in trans.

PLoS Biology, 2022
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is mediated by the entry receptor angiotensin-converting enzyme 2 (ACE2). Although attachment factors and coreceptors facilitating entry are extensively studied, cellular entry ...
Jaewon Song, Ryan D Chow, Mario A Peña-Hernández, Li Zhang, Skylar A Loeb, Eui-Young So, Olin D Liang, Ping Ren, Sidi Chen, Craig B Wilen, Sanghyun Lee   +10 more
doaj   +1 more source

Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model of Camostat Mesylate-Predicted Efficacy against SARS-CoV-2 in COVID-19

Microbiology Spectrum, 2022
The SARS-CoV-2 coronavirus, which causes COVID-19, uses a viral surface spike protein for host cell entry and the human cell-surface transmembrane serine protease, TMPRSS2, to process the spike protein.
Yuri Kosinsky, Kirill Peskov, Donald R. Stanski, Diana Wetmore, Joseph Vinetz   +4 more
doaj   +1 more source

17,β-estradiol inhibits hepatitis C virus mainly by interference with the release phase of its life cycle [PDF]

, 2016
Rationale & Aim: Estrogen and estrogen-mediated signalling protect from hepatitis C virus through incompletely understood mechanisms. We aimed to ascertain which phase(s) of HCV life cycle is/are affected by estrogens.
Barbaglia, Matteo N., Boccato, Elisa, Burlone, Michela E., Cole, Sarah, Foglia, Chiara Z., Giarda, Paola, Grossini, Elena, Magri, Andrea, Minisini, Rosalba, Patel, Arvind H., Pirisi, Mario   +10 more
core   +2 more sources