Results 61 to 70 of about 2,261,873 (405)
Architecture of viral replication factories
Oncotarget, 2015 Compartmentalization of intracellular membrane is a marked characteristic during the pathogenesis of many viruses, which provides a microenvironment for virus to evade the host RNA interference defense response on one hand, and confines various host factors as well as metabolites in a stable space so that they can act in concert to complete virus ...
Yongliang, Zhang +2 more
openaire +2 more sources
Frontiers in Plant Science, 2017 Turnip yellow mosaic virus (TYMV) is a positive-strand RNA virus infecting plants. The TYMV 140K replication protein is a key organizer of viral replication complex (VRC) assembly, being responsible for recruitment of the viral polymerase and for ...
Lucille Moriceau +5 more
doaj +1 more source
Complete replication of hepatitis C virus in cell culture. [PDF]
, 2005 Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research progress on this important human pathogen.
Burton, Dennis R +10 more
core +1 more source
Zika NS1–induced ER remodeling is essential for viral replication
Journal of Cell Biology, 2019 Zika virus induces the formation of vesicles from ER membrane that form viral replication factories in the ER lumen. Ci et al. show that the Zika NS1 protein plays a key role in this remodeling of the ER as the insertion of the hydrophobic regions of NS1
Y. Ci +8 more
semanticscholar +1 more source
Emerging coronaviruses: Genome structure, replication, and pathogenesis
Journal of Medical Virology, 2020 The recent emergence of a novel coronavirus (2019‐nCoV), which is causing an outbreak of unusual viral pneumonia in patients in Wuhan, a central city in China, is another warning of the risk of CoVs posed to public health.
Yu Chen, Qianyun Liu, D. Guo
semanticscholar +1 more source
Lipid Tales of Viral Replication and Transmission. [PDF]
Trends in Cell Biology, 2017 Positive-strand RNA viruses are the largest group of RNA viruses on Earth and cellular membranes are critical for all aspects of their life cycle, from entry and replication to exit. In particular, membranes serve as platforms for replication and as carriers to transmit these viruses to other cells, the latter either as an envelope surrounding a single
N. Altan-Bonnet
semanticscholar +3 more sources
, 1987 Viral replication is the central focus of much experimental virology and is a significant part of molecular biology. Studies with bacteriophages in their prokaryotic host cells in the 1940s and 1950s provided the first insights into the complexities of viral replication. With the development of mammalian cell culture procedures, the techniques used for
FENNER, FRANK +5 more
openaire +1 more source
Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis [PDF]
, 2017 Ebola virus (EBOV) is an enveloped negative-sense RNA virus that causes sporadic outbreaks with high case fatality rates. Ebola viral protein 30 (eVP30) plays a critical role in EBOV transcription initiation at the nucleoprotein (eNP) gene, with ...
Amarasinghe, Gaya K +6 more
core +2 more sources
Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA
Nature Communications, 2018 APOBEC3G (A3G) is a single-stranded DNA (ssDNA) cytidine deaminase that restricts HIV-1. Here the authors provide molecular insights into A3G substrate recognition by determining the 1.86 Å resolution crystal structure of its catalytic domain bound to ...
Atanu Maiti +7 more
doaj +1 more source
UGGT1 enhances enterovirus 71 pathogenicity by promoting viral RNA synthesis and viral replication. [PDF]
PLoS Pathogens, 2017 Positive-strand RNA virus infections can induce the stress-related unfolded protein response (UPR) in host cells. This study found that enterovirus A71 (EVA71) utilizes host UDP-glucose glycoprotein glucosyltransferase 1 (UGGT1), a key endoplasmic ...
Peng-Nien Huang +5 more
doaj +1 more source