Results 1 to 10 of about 13,682 (142)

The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae [PDF]

BMC Genomics, 2008
Background Bordetella petrii is the only environmental species hitherto found among the otherwise host-restricted and pathogenic members of the genus Bordetella.
Schneiker-Bekel Susanne, Rückert Christian, Nakunst Diana, Mormann Sascha, Meyer Folker, Linke Burkhard, Link Stefanie, Larisch Christof, Khachane Amit N, Herrmann Stefanie, Gaigalat Lars, Ebensen Thomas, Choudhuri Jomuna V, Buhrmester Jens, Bartels Daniela, Lechner Melanie, Koebnik Ralf, Pieper Dietmar H, Martins dos Santos Vítor AP, Sebaihia Mohammed, Guzman Carlos A, Gross Roy, Schulze Kai, Vorhölter Frank-Jörg, Yevsa Tetyana, Engle Jacquelyn T, Goldman William E, Pühler Alfred, Göbel Ulf B, Goesmann Alexander, Blöcker Helmut, Kaiser Olaf, Martinez-Arias Rosa   +32 more
doaj   +7 more sources

Nuanced differences in adenylate cyclase toxin production, acylation, and secretion may contribute to the evolution of virulence in Bordetella species [PDF]

mBio
Bordetella pertussis, which causes the acute human disease whooping cough, evolved from Bordetella bronchiseptica, which causes long-term, chronic infections in a broad range of mammals. Both B. pertussis and B.
Alexa R. Wolber, Liliana S. McKay, Katlyn B. Mote, Richard M. Johnson, Carol S. Inatsuka, Peggy A. Cotter   +5 more
doaj   +2 more sources

Understanding the Mechanism of Translocation of Adenylate Cyclase Toxin across Biological Membranes [PDF]

Toxins, 2017
Adenylate cyclase toxin (ACT) is one of the principal virulence factors secreted by the whooping cough causative bacterium Bordetella pertussis, and it has a critical role in colonization of the respiratory tract and establishment of the disease.
Helena Ostolaza, César Martín, David González-Bullón, Kepa B. Uribe, Asier Etxaniz   +4 more
doaj   +5 more sources

Interplay of virulence factors and signaling molecules: albumin and calcium-mediated biofilm regulation in Bordetella bronchiseptica [PDF]

Journal of Bacteriology
Bordetella bronchiseptica, a respiratory pathogen capable of infecting various mammals, including humans, is associated with chronic infections. B.
Sabrina Laura Mugni, Nicolás Ambrosis, George A. O´Toole, Federico Sisti, Julieta Fernández   +4 more
doaj   +2 more sources

The type III secreted protein BspR regulates the virulence genes in Bordetella bronchiseptica. [PDF]

PLoS ONE, 2012
Bordetella bronchiseptica is closely related with B. pertussis and B. parapertussis, the causative agents of whooping cough. These pathogenic species share a number of virulence genes, including the gene locus for the type III secretion system (T3SS ...
Jun Kurushima, Asaomi Kuwae, Akio Abe
doaj   +1 more source

Pathogenicity and virulence of Bordetella pertussis and its adaptation to its strictly human host

Virulence, 2021
The highly contagious whooping cough agent Bordetella pertussis has evolved as a human-restricted pathogen from a progenitor which also gave rise to Bordetella parapertussis and Bordetella bronchiseptica.
Thomas Belcher, Violaine Dubois, Alex Rivera-Millot, Camille Locht, Françoise Jacob-Dubuisson   +4 more
doaj   +1 more source

Identification of a CO2 responsive regulon in Bordetella. [PDF]

PLoS ONE, 2012
Sensing the environment allows pathogenic bacteria to coordinately regulate gene expression to maximize survival within or outside of a host. Here we show that Bordetella species regulate virulence factor expression in response to carbon dioxide levels ...
Sara E Hester, Minghsun Lui, Tracy Nicholson, Daryl Nowacki, Eric T Harvill   +4 more
doaj   +1 more source

Characterization of a Bvg-regulated fatty acid methyl-transferase in Bordetella pertussis. [PDF]

PLoS ONE, 2017
The whooping cough agent Bordetella pertussis controls the expression of its large virulence regulon in a coordinated manner through the two-component signal transduction system BvgAS.
Alex Rivera-Millot, Elodie Lesne, Luis Solans, Loic Coutte, Justine Bertrand-Michel, Philippe Froguel, Véronique Dhennin, David Hot, Camille Locht, Rudy Antoine, Françoise Jacob-Dubuisson   +10 more
doaj   +1 more source

Conquering the host: Bordetella spp. and Pseudomonas aeruginosa molecular regulators in lung infection

Frontiers in Microbiology, 2022
When bacteria sense cues from the host environment, stress responses are activated. Two component systems, sigma factors, small RNAs, ppGpp stringent response, and chaperones start coordinate the expression of virulence factors or immunomodulators to ...
Alina M. Holban, Alina M. Holban, Courtney M. Gregoire, Monica C. Gestal   +3 more
doaj   +1 more source

A Mutation Upstream of the rplN-rpsD Ribosomal Operon Downregulates Bordetella pertussis Virulence Factor Production without Compromising Bacterial Survival within Human Macrophages

mSystems, 2020
The BvgS/BvgA two-component system controls expression of ∼550 genes of Bordetella pertussis, of which, ∼245 virulence-related genes are positively regulated by the BvgS-phosphorylated transcriptional regulator protein BvgA (BvgA∼P).
Jakub Novák, David Jurnečka, Irena Linhartová, Jana Holubová, Ondřej Staněk, Daniel Štipl, Ana Dienstbier, Branislav Večerek, Nayara Azevedo, Jan Provazník, Vladimír Beneš, Peter Šebo   +11 more
doaj   +1 more source