Results 71 to 80 of about 13,721 (179)

The Role of Virulence Proteins in Protection Conferred by Bordetella pertussis Outer Membrane Vesicle Vaccines

Vaccines, 2020
The limited protective immunity induced by acellular pertussis vaccines demands development of novel vaccines that induce broader and longer-lived immunity.
René H. M. Raeven, Naomi van Vlies, Merijn L. M. Salverda, Larissa van der Maas, Joost P. Uittenbogaard, Tim H. E. Bindels, Jolanda Rigters, Lisa M. Verhagen, Sabine Kruijer, Elly van Riet, Bernard Metz, Arno A. J. van der Ark   +11 more
doaj   +1 more source

Allelic variations between vaccine strains and circulating strains in pxtP of Bordetella pertussis in Iran

Vaccine Research, 2015
Introduction: Despite high level of vaccination against pertussis‚ whooping cough has re-emerged as a health threat, especially in infants. This could be related to expansion of Bordetella pertussis with novel alleles for virulence factors including the ...
F Sadeghpour Heravi, VS Nikbin, F Shahcheraghi   +2 more
doaj  

Soil Properties Induced Changes in the Microbial Communities Associated With Potato Tubers Grown in Different Lowland Fields of Northern Thailand

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
Microbial communities on potato tubers in northern Thailand were studied with 16S and ITS amplicon sequencing. It was found that soil pH and organic matter are key drivers of bacterial and fungal composition, affecting the balance between pathogens and beneficial microbes.
Pipat Macharoen, Wuttichai Mhuantong, Thippawan Wannawong, Wiphawee Leesutthiphonchai, Onuma Piasai, Somboon Tanasupawat, Nakarin Suwannarach, Nattakorn Kuncharoen   +7 more
wiley   +1 more source

Yin and yang of interleukin-17 in host immunity to infection [version 1; referees: 2 approved] [PDF]

, 2017
The interleukin-17 (IL-17) family cytokines, such as IL-17A and IL-17F, play important protective roles in host immune response to a variety of infections such as bacterial, fungal, parasitic, and viral.
Das, Shibali, Khader, Shabaana
core   +3 more sources

Practical Application of Disease Risk Assessment in Native Species Reintroductions: A Case Study of a European Wildcat (Felis silvestris) Population Reinforcement in the Cairngorms National Park

Mammal Review, Volume 55, Issue 4, October 2025.
Disease risk assessment was conducted for the Saving Wildcats reintroduction project of captive‐bred European Wildcats (Felis silvestris) to the Cairngorms National Park. Hazards were identified, and appropriate pre‐and post‐release mitigation strategies were identified and implemented, illustrating the direct conservation application and significance ...
Alice Bacon, Beatriz S. G. Alves, Simon Girling, Adam Naylor   +3 more
wiley   +1 more source

The BvgAS Regulon of Bordetella pertussis

mBio, 2017
Nearly all virulence factors in Bordetella pertussis are activated by a master two-component system, BvgAS, composed of the sensor kinase BvgS and the response regulator BvgA.
Kyung Moon, Richard P. Bonocora, David D. Kim, Qing Chen, Joseph T. Wade, Scott Stibitz, Deborah M. Hinton   +6 more
doaj   +1 more source

Changes in the genomic content of circulating Bordetella pertussis strains isolated from the Netherlands, Sweden, Japan and Australia: adaptive evolution or drift? [PDF]

, 2010
Background Bordetella pertussis is the causative agent of human whooping cough (pertussis) and is particularly severe in infants. Despite worldwide vaccinations, whooping cough remains a public health problem.
Audrey J King, Tamara van Gorkom, Han GJ van der Heide, Abdolreza Advani, Saskia van der Lee   +4 more
core   +1 more source

Immunity Switches and Macrophage Manipulations: Trauma, Ovulation, and Depression as Latent Tuberculosis Reactivation Risks

American Journal of Human Biology, Volume 37, Issue 9, September 2025.
ABSTRACT Inflammation is the immune system's natural response to initial tuberculosis infection. Tuberculosis bacteria have gained adaptations to manipulate the inflammatory process, sometimes settling into latency and containment in granulomas, ensuring their survival.
Stacie Burke
wiley   +1 more source

Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains [PDF]

, 2007
BACKGROUND: Francisella tularensis subspecies tularensis and holarctica are pathogenic to humans, whereas the two other subspecies, novicida and mediasiatica, rarely cause disease. To uncover the factors that allow subspecies tularensis and holarctica to
Laurence Rohmer, Christine Fong, Simone Abmayr, Michael Wasnick, Theodore Larson Freeman, Matthew Radey, Tina Guina, Kerstin Svensson, Hillary S Hayden, Michael Jacobs, Larry A Gallagher, Colin Manoil, Robert K Ernst, Becky Drees, Danielle Buckley, Eric Haugen, Donald Bovee, Yang Zhou, Jean Chang, Ruth Levy, Regina Lim, Will Gillett, Don Guenthener, Allison Kang, Scott A Shaffer, Greg Taylor, Jinzhi Chen, Byron Gallis, David A D'Argenio, Mats Forsman, Maynard V Olson, David R Goodlett, Rajinder Kaul, Samuel I Miller, Mitchell J Brittnacher   +34 more
core   +1 more source

Outer Membrane Vesicles as a Versatile Platform for Vaccine Development: Engineering Strategies, Applications and Challenges

Journal of Extracellular Vesicles, Volume 14, Issue 9, September 2025.
ABSTRACT Outer membrane vesicles (OMVs) are nanosized vesicles naturally secreted by Gram‐negative bacteria and represent a promising platform for vaccine development. OMVs possess inherent immunostimulatory properties due to the presence of pathogen‐associated molecular patterns (PAMPs), providing self‐adjuvanting capabilities and the ability to ...
Asja Garling, Frédéric Auvray, Mathieu Epardaud, Éric Oswald, Priscilla Branchu   +4 more
wiley   +1 more source