Results 1 to 10 of about 119,805 (200)

Versatile virus-like particle carrier for epitope based vaccines. [PDF]

PLoS ONE, 2010
BACKGROUND: Recombinant proteins and in particular single domains or peptides are often poorly immunogenic unless conjugated to a carrier protein. Virus-like-particles are a very efficient means to confer high immunogenicity to antigens.
Alain C Tissot, Regina Renhofa, Nicole Schmitz, Indulis Cielens, Edwin Meijerink, Velta Ose, Gary T Jennings, Philippe Saudan, Paul Pumpens, Martin F Bachmann   +9 more
doaj   +3 more sources

Special Issue “Virus-Like Particle Vaccines” [PDF]

Viruses, 2020
Virus-like particles (VLPs) have become a key tool for vaccine developers and manufacturers [...]
Monique Vogel, Martin F. Bachmann
doaj   +4 more sources

Preclinical Development of a Novel Zika Virus-like Particle Vaccine in Combination with Tetravalent Dengue Virus-like Particle Vaccines [PDF]

Vaccines
Declared as a Public Health Emergency in 2016 by the World Health Organization (WHO), the Zika virus (ZIKV) continues to cause outbreaks that are linked to increased neurological complications.
Dominik A. Rothen, Sudip Kumar Dutta, Pascal S. Krenger, Alessandro Pardini, Anne-Cathrine S. Vogt, Romano Josi, Ilva Lieknina, Albert D. M. E. Osterhaus, Mona O. Mohsen, Monique Vogel, Byron Martina, Kaspars Tars, Martin F. Bachmann   +12 more
doaj   +2 more sources

Four nudivirus core genes present in the genome of Venturia canescens are required for virus-like particle formation and prevention of encapsulation of parasitoid wasp eggs [PDF]

Journal of Virology
Venturia canescens is a parasitoid wasp that harbors a domesticated endogenous virus (DEV) and parasitizes host insects like Ephestia kuehniella. The V. canescens DEV evolved from an alphanudivirus and produces virus-like particles (VLPs) in females that
Meng Mao, Corinne M. Stouthamer, Ange Lorenzi, Michael R. Strand, Gaelen R. Burke   +4 more
doaj   +2 more sources

Immunogenicity and efficacy of an mRNA vaccine expressing a virus-like particle spike antigen against SARS-CoV-2. [PDF]

NPJ Vaccines
Laliberte JP, Cai Y, Kenny T, Zhang Y, Ren K, Rosenthal K, Flores D, Roque R, Acton O, Peano VC, Janney N, Puri V, Siddiqui S, Pack A, Padilla G, Diallo S, Adissu H, Choudhary R, Pruitt H, Cheng YH, Thom G, Newton M, Kurokawa C, Guest J, Swanson P, Loo YM, Francica JR, Blair W, Esser M.   +28 more
europepmc   +3 more sources

Optimization and validation of a virus‐like particle pseudotyped virus neutralization assay for SARS‐CoV‐2 [PDF]

MedComm
Spike‐protein‐based pseudotyped viruses were used to evaluate vaccines during the COVID‐19 pandemic. However, they cannot be used to evaluate the envelope (E), membrane (M), and nucleocapsid (N) proteins. The first generation of virus‐like particle (VLP)
Shuo Liu, Li Zhang, Wangjun Fu, Ziteng Liang, Yuanling Yu, Tao Li, Jincheng Tong, Fan Liu, Jianhui Nie, Qiong Lu, Shuaiyao Lu, Weijin Huang, Youchun Wang   +12 more
doaj   +2 more sources

Advances in virus-like particle-based SARS-CoV-2 vaccines [PDF]

Frontiers in Cellular and Infection Microbiology
The Coronavirus Disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has incurred devastating human and economic losses. Vaccination remains the most effective approach for controlling the COVID-19
Xiaoting Hao, Feifei Yuan, Xuan Yao
doaj   +2 more sources

Epitope-Specific Anti-hCG Vaccines on a Virus Like Particle Platform. [PDF]

PLoS ONE, 2015
The possibility of a contraceptive vaccine targeting human chorionic gonadotropin has long been recognized, but never fully realized. Here we describe an epitope-specific approach based on immunogenic display of hCG-derived peptides on virus-like ...
Jerri Caldeira, Jeremiah Bustos, Julianne Peabody, Bryce Chackerian, David S Peabody   +4 more
doaj   +1 more source

Programmable polymorphism of a virus-like particle

Communications Materials, 2022
Virus-like particles are promising for drug delivery systems and vaccine development, but controlling their size and morphology is challenging. Here, amino acid sequences are inserted into MS2 bacteriophage virus-like particles, with their size and shape
Artur P. Biela, Antonina Naskalska, Farzad Fatehi, Reidun Twarock, Jonathan G. Heddle   +4 more
doaj   +1 more source

Zika virus-like particle (VLP) based vaccine. [PDF]

PLoS Neglected Tropical Diseases, 2017
The newly emerged mosquito-borne Zika virus poses a major public challenge due to its ability to cause significant birth defects and neurological disorders.
Hélène Boigard, Alexandra Alimova, George R Martin, Al Katz, Paul Gottlieb, Jose M Galarza   +5 more
doaj   +1 more source