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Virology Journal, 2023 Vaccine efficacy of conventional influenza vaccines depend on the antigenic similarity between the selected vaccine strain and annual epidemic strain. Since the influenza virus evolves yearly, a vaccine which is independent from viral antigenic mutation ...
Toshifumi Imagawa +4 more
doaj +1 more source
Vaccines, 2021 Capsid-like particle (CLP) displays can be used to enhance the immunogenicity of vaccine antigens, but a better understanding of how CLP vaccines are best formulated and delivered is needed.
Christoph M. Janitzek +10 more
doaj +1 more source
A facile quantitative assay for viral particle genesis reveals cooperativity in virion assembly and saturation of an antiviral protein [PDF]
, 2012 Conventional assays of viral particle assembly and release are time consuming and laborious. We have developed an enzymatic virus-like particle (VLP) genesis assay that rapid and quantitative and is also versatile and applicable to diverse viruses ...
Capul +30 more
core +1 more source
Virus-like Particles: Measures and Biological Functions
Viruses, 2022 Virus-like particles resemble infectious virus particles in size, shape, and molecular composition; however, they fail to productively infect host cells.
Tara Bhat, Amy Cao, John Yin
doaj +1 more source
Evaluation of electrospray differential mobility analysis for virus particle analysis: Potential applications for biomanufacturing. [PDF]
, 2011 The technique of electrospray differential mobility analysis (ES-DMA) was examined as a potential potency assay for routine virus particle analysis in biomanufacturing environments (e.g., evaluation of vaccines and gene delivery products for lot release)
Brorson, Kurt A +4 more
core +1 more source
Norwalk virus-like particles as vaccines [PDF]
Expert Review of Vaccines, 2010 Noroviruses (NoV) cause the great majority of epidemic nonbacterial gastroenteritis in humans. Expression of the capsid protein in recombinant systems, including insect and plant cells, yields assembly of virus-like particles (VLPs) that mimic the antigenic structure of authentic virions, and are relatively acid- and heat-stable.
Melissa M. Herbst-Kralovetz +2 more
openaire +3 more sources
HIV-1 Virus-like Particle Budding Assay
Bio-Protocol, 2013 Viral replication culminates with the egress of the mature virion from the host cell. This step of the viral life cycle has recently garnered increased attention with the discovery of the cellular restriction factor, Tetherin, which tethers budded ...
Nathan Vande Burgt +2 more
doaj +1 more source
The potential for reassortment between Oropouche and Schmallenberg Orthobunyaviruses [PDF]
, 2017 A number of viruses within the Peribunyaviridae family are naturally occurring reassortants, a common phenomenon for segmented viruses. Using a minigenome-reporter and virus-like particle (VLP) production assay, we have accessed the potential of ...
Elliott, Richard M. +3 more
core +1 more source
Identification of Novel Adjuvants for Ebola Virus-Like Particle Vaccine
Vaccines, 2020 Ebola virus disease is a severe disease, often fatal, with a mortality rate of up to 90%. Presently, effective treatment and safe prevention options for Ebola virus disease are not available. Therefore, there is an urgent need to develop control measures
Huapeng Feng +7 more
doaj +1 more source
Virus-like particles as vaccine.
Acta Biochimica Polonica, 2014 This review presents data on commercial and experimental virus-like particle (VLP) vaccines, including description of VLP vaccines against influenza. Virus-like particles are multimeric, sometimes multiprotein nanostructures assembled from viral structural proteins and are devoid of any genetic material. VLPs present repetitive high-density displays of
Inga Szurgot +2 more
openaire +4 more sources