Results 31 to 40 of about 119,805 (200)

Immunogenicity of Virus Like Particle Forming Baculoviral DNA Vaccine against Pandemic Influenza H1N1. [PDF]

PLoS ONE, 2016
An outbreak of influenza H1N1 in 2009, representing the first influenza pandemic of the 21st century, was transmitted to over a million individuals and claimed 18,449 lives.
Yong-Dae Gwon, Sehyun Kim, Yeondong Cho, Yoonki Heo, Hansam Cho, Kihoon Park, Hee-Jung Lee, Jiwon Choi, Haryoung Poo, Young Bong Kim   +9 more
doaj   +1 more source

Bioanalytics for Influenza Virus-Like Particle Characterization and Process Monitoring

Frontiers in Bioengineering and Biotechnology, 2022
Virus-like particles (VLPs) are excellent platforms for the development of influenza vaccine candidates. Nonetheless, their characterization is challenging due to VLPs’ unique biophysical and biochemical properties. To cope with such complexity, multiple
Sofia B. Carvalho, Sofia B. Carvalho, Ricardo J. S. Silva, Ricardo J. S. Silva, Marcos F. Q. Sousa, Marcos F. Q. Sousa, Cristina Peixoto, Cristina Peixoto, António Roldão, António Roldão, Manuel J. T. Carrondo, Paula M. Alves, Paula M. Alves   +12 more
doaj   +1 more source

Virus-like particle vaccines containing F or F and G proteins confer protection against respiratory syncytial virus without pulmonary inflammation in cotton rats

Human Vaccines & Immunotherapeutics, 2017
Vaccine-enhanced disease has been a major obstacle in developing a safe vaccine against respiratory syncytial virus (RSV). This study demonstrates the immunogenicity, efficacy, and safety of virus-like particle (VLP) vaccines containing RSV F (F VLP), G (
Hye Suk Hwang, Ki-Hye Kim, Youri Lee, Young-Tae Lee, Eun-Ju Ko, SooJin Park, Jong Seok Lee, Byung-cheol Lee, Young-Man Kwon, Martin L. Moore, Sang-Moo Kang   +10 more
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Toll-like receptor agonist augments virus-like particle-mediated protection from Ebola virus with transient immune activation.

PLoS ONE, 2014
Identifying safe and effective adjuvants is critical for the advanced development of protein-based vaccines. Pattern recognition receptor (PRR) agonists are increasingly being explored as potential adjuvants, but there is concern that the efficacy of ...
Karen A O Martins, Jesse T Steffens, Sean A van Tongeren, Jay B Wells, Alison A Bergeron, Samuel P Dickson, John M Dye, Andres M Salazar, Sina Bavari   +8 more
doaj   +1 more source

Characterization of Chikungunya Virus-Like Particles

PLoS ONE, 2014
El virus Chikungunya (CHIKV) se está convirtiendo en una preocupación mundial debido al creciente número de brotes en todo el mundo y la ausencia de cualquier vacuna o tratamiento específico contra el CHIKV. Las partículas similares a virus (VLP) son proteínas multiestructuradas que imitan la organización y conformación de los virus nativos, pero ...
Nitchakarn Noranate, Naokazu Takeda, Prukswan Chetanachan, Pathompong Sittisaman, Atchareeya A-Nuegoonpipat, Surapee Anantapreecha   +5 more
openaire   +4 more sources

Radiation Brightening from Virus-like Particles [PDF]

ACS Nano, 2019
Concentration quenching is a well-known challenge in many fluorescence imaging applications. Here we show that the optical emission from hundreds of chromophores confined onto the surface of a virus particle 28 nm diameter can be recovered under pulsed irradiation.
Irina B. Tsvetkova, Arathi Anil Sushma, Joseph Che-Yen Wang, William L. Schaich, Bogdan Dragnea   +4 more
openaire   +3 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source