Results 41 to 50 of about 731,035 (329)

Norwalk virus-like particles as vaccines [PDF]

Expert Review of Vaccines, 2010
Noroviruses (NoV) cause the great majority of epidemic nonbacterial gastroenteritis in humans. Expression of the capsid protein in recombinant systems, including insect and plant cells, yields assembly of virus-like particles (VLPs) that mimic the antigenic structure of authentic virions, and are relatively acid- and heat-stable.
Melissa, Herbst-Kralovetz, Hugh S, Mason, Qiang, Chen   +2 more
openaire   +2 more sources

Virus Like Particles (VLP) as multivalent vaccine candidate against Chikungunya, Japanese Encephalitis, Yellow Fever and Zika Virus

Scientific Reports, 2020
Mosquito borne viral diseases are an emerging threat as evident from the recent outbreak of Zika virus (ZIKV) as well as repeated outbreaks of Chikungunya (CHIKV), Yellow fever (YFV) and Japanese encephalitis (JEV) virus in different geographical regions.
H. Garg, Tugba Mehmetoglu-Gurbuz, A. Joshi   +2 more
semanticscholar   +1 more source

N,N'-dimethylnitrosourea-induced tumors in mice and Syrian hamsters [PDF]

, 1974
Carcinogenic effect of N, N'-dimethylnitrosourea (DMNU) on mice and hamsters was studied. Repeated subcutaneous injections　of DMNU resulted in the induction of malignant lymphomas with an　incidence of 100 per cent in adult C3HjBifBjKi mice ...
Hiraki, Shunkichi
core   +1 more source

Ultrastructural aspects of virus replication in one fatal case and several other isolates from a dengue type 2 outbreak in Rio de Janeiro

Memorias do Instituto Oswaldo Cruz, 1994
Dengue virus replication in mosquito cell cultures was observed by electron microscopy in one fatal and 40 classical isolates from a dengue type 2 outbreak in Rio de Janeiro and compared with the prototype New Guinea C strain.
Ortrud Monika Barth, Luzia Monteiro de Castro Côrtes, Elisabeth Lampe, José da Costa Farias Filho   +3 more
doaj   +1 more source

A Compensatory Liability Regime to Promote the Exchange of Microbial Genetic Resources for Research and Benefit Sharing [PDF]

, 2011
Female rhesus macaques were immunized with HIV virus-like particles (HIV-VLPs) or HIV DNA administered as sequential combinations of mucosal (intranasal) and systemic (intramuscular) routes, according to homologous or heterologous prime-boost schedules ...
Andersen, Hanne, Buonaguro, Franco M., Buonaguro, Luigi, Hinkula, Jorma, Lewis, Mark, Pal, Ranajit, Schroeder, Ulf, Tagliamonte, Maria, Torneselloa, Maria Lina, Visciano, Maria Luisa, Wahren, Britta   +10 more
core   +2 more sources

Recent Advances in the Use of Plant Virus-Like Particles as Vaccines

Viruses, 2020
Vaccination is one of the most effective public health interventions of the 20th century. All vaccines can be classified into different types, such as vaccines against infectious diseases, anticancer vaccines and vaccines against autoimmune diseases.
Ina Baļķe, A. Zeltins
semanticscholar   +1 more source

Adjuvant formulated virus-like particles expressing native-like forms of the Lassa virus envelope surface glycoprotein are immunogenic and induce antibodies with broadly neutralizing activity [PDF]

, 2020
Lassa mammarenavirus (LASV) is a rodent-borne arenavirus endemic to several West African countries. It is the causative agent of human Lassa fever, an acute viral hemorrhagic fever disease.
Ball, Jonathan K., Bauer, Stefan, Becker, Stephan, Dorna, Jens, Fehling, Sarah Katharina, Fichet-Calvet, Elisabeth, Kaufmann, Andreas, Kolesnikova, Larissa, Krebs, Yvonne, Krähling, Verena, Magassouba, N’Faly, Müller, Helena, Oestereich, Lisa, Schauflinger, Martin, Strecker, Thomas, Urbanowicz, Richard A., von Messling, Veronika   +16 more
core   +2 more sources

Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo

Nature Biotechnology
Prime editing enables precise installation of genomic substitutions, insertions and deletions in living systems. Efficient in vitro and in vivo delivery of prime editing components, however, remains a challenge.
Meirui An, Aditya Raguram, Samuel W. Du, Samagya Banskota, Jessie R. Davis, Gregory A. Newby, Paul Z. Chen, Krzysztof Palczewski, David R Liu   +8 more
semanticscholar   +1 more source

Brome mosaic virus-like particles as siRNA nanocarriers for biomedical purposes

Beilstein Journal of Nanotechnology, 2020
There is an increasing interest in the use of plant viruses as vehicles for anti-cancer therapy. In particular, the plant virus brome mosaic virus (BMV) and cowpea chlorotic mottle virus (CCMV) are novel potential nanocarriers for different therapies in ...
Alfredo Nuñez-Rivera, Pierrick G. J. Fournier, Danna L. Arellano, A. Rodríguez-Hernández, R. Vázquez-Duhalt, R. Cadena-Nava   +5 more
semanticscholar   +1 more source

The effects of high shear rates on the average hydrodynamic diameter measured in biomimetic HIV Gag virus-like particle dispersions

Frontiers in Bioengineering and Biotechnology
HIV Gag virus-like particles (HIV Gag VLPs) are promising HIV vaccine candidates. In the literature, they are often described as shear-sensitive particles, and authors usually recommend the operation of tangential flow filtration (TFF) gently at shear ...
Tobias Wolf, Tobias Wolf, Kerim Kadir Calisan, Jörn Stitz, Stéphan Barbe   +4 more
doaj   +1 more source