Results 131 to 140 of about 106,533 (346)

Role for the liver X receptor agonist 22‐ketositosterol in preventing disease progression in an Alzheimer's disease mouse model

British Journal of Pharmacology, EarlyView.
Background and Purpose Liver X receptors (LXRs) are promising therapeutic targets for alleviating Alzheimer's disease (AD) symptoms. We assessed the impact of the semi‐synthetic LXR agonist 22‐ketositosterol on disease progression in an AD mouse model.
Nikita Martens, Na Zhan, Sammie C. Yam, Marcella Palumbo, Lorenzo Pontini, Frank P. J. Leijten, Leonie van Vark‐van der Zee, Gardi Voortman, Silvia Friedrichs, Albert Gerding, Maura Marinozzi, Johan W. Jonker, Folkert Kuipers, Dieter Lütjohann, Tim Vanmierlo, Monique T. Mulder   +15 more
wiley   +1 more source

Chylomicron- and VLDL-derived Lipids Enter the Heart through Different Pathways

Journal of Biological Chemistry, 2010
Lipids circulate in the blood in association with plasma lipoproteins and enter the tissues either after hydrolysis or as non-hydrolyzable lipid esters.
Kalyani G. Bharadwaj, Y. Hiyama, Yunying Hu, L. Huggins, R. Ramakrishnan, N. Abumrad, G. Shulman, W. Blaner, I. Goldberg   +8 more
semanticscholar   +1 more source

Plasma lipoprotein metabolism in lean and in fat chickens produced by divergent selection for plasma very low density lipoprotein concentration.

Journal of Lipid Research, 1989
Plasma lipoprotein metabolism was studied in vivo in two lines of chickens produced by selection for high and low plasma very low density lipoprotein (VLDL) concentration.
H Griffin, F Acamovic, K Guo, J Peddie
doaj  

Effects of estradiol on very low density lipoprotein receptor mRNA levels in rabbit heart [PDF]

, 1994
The VLDL receptor, a newly identified lipoprotein receptor, has a domain structure homologous with the LDL receptor but has one additional cysteine rich repeat in the ligand binding domain.
Jingami, Hisato, Masuzaki, Hiroaki, Nakao, Kazuwa, Yamamoto, Tokuo   +3 more
core   +1 more source

Targeting Regulation of Macrophage to Treat Metabolic Disease: Role of Phytochemicals

Cell Proliferation, EarlyView.
One‐third of the world's population is affected by metabolic syndrome. Complicated pathogenesis and limited drugs cause the growing prevalence of metabolic syndrome. Macrophage‐mediated metaflammation is closely associated with the development of metabolic syndrome. The role of phytochemicals targeting macrophages in the treatment of metabolic syndrome
Zeting Ye, Yanlin Li, Xiaolin Yang, Chenglin Li, Rui Yu, Guangjuan Zheng, Zuqing Su   +6 more
wiley   +1 more source

VLDL hydrolysis by LPL activates PPAR-α through generation of unbound fatty acids

Journal of Lipid Research, 2010
Recent evidence suggests that lipoproteins serve as circulating reservoirs of peroxisomal proliferator activated receptor (PPAR) ligands that are accessible through lipolysis.
Maxwell A. Ruby, Benjamin H Goldenson, Gabriela Orasanu, T. Johnston, J. Plutzky, R. Krauss   +5 more
semanticscholar   +1 more source

Familial LCAT Deficiency and Low HDL-C Levels: In silico Characterization of Two Rare LCAT Missense Mutations

The Application of Clinical Genetics
Sebastian Ciro Acosta,1 Lorena Díaz-Ordóñez,1,2 Juan David Gutierrez-Medina,1,3 Yisther Katherine Silva-Cuero,1,2 Luis Guillermo Arango-Vélez,4,5 Andrés Octavio García-Trujillo,4,5 Harry Pachajoa1,2,6 1Centro de Investigaciones en Anomalias Congenitas y ...
Ciro Acosta S, Díaz-Ordóñez L, Gutierrez-Medina JD, Silva-Cuero YK, Arango-Vélez LG, García-Trujillo AO, Pachajoa H   +6 more
doaj  

Oxidized type IV hypertriglyceridemic VLDL-remnants cause greater macrophage cholesteryl ester accumulation than oxidized LDL

Journal of Lipid Research, 1998
We have previously shown that very low density lipoproteins (VLDL, Sf 60–400) from subjects with type IV hyperlipoproteinemia (HTG-VLDL) will induce appreciable cholesteryl ester accumulation in cultured macrophages (J774A.1).
Stewart C. Whitman, Cynthia G. Sawyez, David B. Miller, Bernard M. Wolfe, Murray W. Huff   +4 more
doaj  

Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats [PDF]

, 2010
We investigated the influence of high sucrose diet (HSD) after 3 or 5 weeks of administration on paraoxonase 1 (PON1) activity in plasma of normolipidemic rats and the relationship between serum PON1 activity, triacylglycerides (TGs), HDL and total ...
Bradamante, Vlasta, Lucić Vrdoljak, Ana, Macan, Marija, Radić, Božica, Vrkić, Nada   +4 more
core  

Obesity‐related glomerulopathy: How it happens and future perspectives

Diabetic Medicine, EarlyView.
Abstract Obesity‐related glomerulopathy (ORG) is an emerging complication of excess adiposity. Its incidence rises alongside the obesity pandemic. Up to 40% of individuals can be affected by ORG, irrespective of the status of glomerular filtration rate and albuminuria.
Jian‐Wen Samuel Lee‐Boey, Jia‐Kai Tan, Zhan‐Foong Lim, Francesco Zaccardi, Kamlesh Khunti, Majid Ezzati, Edward W. Gregg, Lee‐Ling Lim   +7 more
wiley   +1 more source