Results 41 to 50 of about 14,132 (209)
Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.Abstract INTRODUCTION Alzheimer's disease (AD) is a complex neurodegenerative disorder. Hundreds of therapeutic targets have been nominated through genetic and multi‐omic studies, but effective prioritization remains a major bottleneck. METHODS We applied an integrative screening framework to assess 29 candidate targets from risk‐enriched biological ...
Gregory A. Cary +12 more
wiley +1 more source
Genome-wide prediction of human VNTRs
Genomics, 2005 Polymorphic minisatellites, also known as variable number of tandem repeats (VNTRs), are tandem repeat regions that show variation in the number of repeat units among chromosomes in a population. Currently, there are no general methods for predicting which minisatellites have a high probability of being polymorphic, given their sequence characteristics.
Karl, Näslund +5 more
openaire +2 more sources
A Mycobacterium leprae VNTR database
Leprosy Review, 2010 A great deal of the last quarter of a century’s astonishing progress in understanding and treating human disease is attributable to the existence of public databases where information about DNA sequences, protein sequences, protein structures, human variation, etc. is stored and is freely available to all interested investigators.
openaire +2 more sources
Cell GenomicsSummary: Variable number tandem repeat (VNTR) is a pervasive and highly mutable genetic feature that varies in both length and repeat sequence. Despite the well-studied copy-number variants, the functional impacts of repeat motif polymorphisms remain ...
Sijia Zhang +13 more
doaj +1 more source
Инфекция и иммунитет, 2018 . Background. Mycobacterium avium subsp. hominissuis (MAH) is an important pathogen responsible for most of the human-associated nontuberculous mycobacteria infections.
M. Menichini +3 more
doaj +1 more source
vamos: VNTR annotation using efficient motif sets
, 2022 AbstractMotivationRoughly 3% of the human genome is composed of variable-number tandem repeats (VNTRs): tandemly repeated arrays of motifs at least six bases. These loci are highly polymorphic: over 61% of insertion and deletion variants at least 50 bases found from long-read assemblies are inside VNTRs.
Jingwen Ren, Bida Gu, Chaisson, Mark JP
openaire +1 more source
Aging Cell, Volume 24, Issue 12, December 2025.A fundamental understanding of the Alzheimer’s disease (AD) specific trajectory of LINE1 has been limited. This study reveals an unanticipated U‐shaped trajectory of LINE1 content and expression in both wild‐type and AD mouse brains, and discerns specific changes in LINE1 content and expression tied to AD neuropathology in a sex‐different manner.
Minyan Jiang +9 more
wiley +1 more source
Evolutionary history of the PER3 variable number of tandem repeats (VNTR): idiosyncratic aspect of primate molecular circadian clock. [PDF]
PLoS ONE, 2014 The PER3 gene is one of the clock genes, which function in the core mammalian molecular circadian system. A variable number of tandem repeats (VNTR) locus in the 18th exon of this gene has been strongly associated to circadian rhythm phenotypes and sleep
Flávia Cal Sabino +7 more
doaj +1 more source
A Genome-Wide Screen for the Exonisation of Reference SINE-VNTR-Alus and Their Expression in CNS Tissues of Individuals with Amyotrophic Lateral Sclerosis [PDF]
, 2023 Abigail L. Pfaff +3 more
openalex +1 more source
Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.Abstract INTRODUCTION Faulty DNA repair and epigenetic regulation contribute to neurodegeneration in Alzheimer's disease. Long‐read sequencing enables analysis of “dark regions” that are difficult to study via traditional sequencing methodologies.
Paulino Ramirez +8 more
wiley +1 more source