Voltage-Dependent Anion Channel 1 Expression in Oral Malignant and Premalignant Lesions [PDF]
Diagnostics, 2023 Background: The voltage-dependent anion channel 1 protein (VDAC1) plays a role in cellular metabolism and survival. It was found to be down or upregulated (overexpressed) in different malignancies but it was never studied in application to oral lesions ...
Irit Allon +5 more
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Voltage-dependent anion channel 1 oligomerization regulates PANoptosis in retinal ischemia–reperfusion injury [PDF]
Neural Regeneration ResearchIschemia–reperfusion injury is a common pathophysiological mechanism in retinal degeneration. PANoptosis is a newly defined integral form of regulated cell death that combines the key features of pyroptosis, apoptosis, and necroptosis. Oligomerization of
Hao Wan +8 more
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Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics [PDF]
Frontiers in Oncology, 2017 Cancer cells share several properties, high proliferation potential, reprogramed metabolism, and resistance to apoptotic cues. Acquiring these hallmarks involves changes in key oncogenes and non-oncogenes essential for cancer cell survival and prosperity,
Varda Shoshan-Barmatz +3 more
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Voltage-Dependent Anion Channel-1, a Possible Ligand of Plasminogen Kringle 5. [PDF]
PLoS ONE, 2016 Kringle 5, the fifth fragment of plasminogen, is known to be important for inhibiting the proliferation and migration of vascular endothelial cell (VEC), while not having any effects on normal endothelial cells.
Yin-Ku Liang, Liu-Jiao Bian
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Voltage-Dependent Anion Channel 1(VDAC1) Participates the Apoptosis of the Mitochondrial Dysfunction in Desminopathy. [PDF]
PLoS ONE, 2016 Desminopathies caused by the mutation in the gene coding for desmin are genetically protein aggregation myopathies. Mitochondrial dysfunction is one of pathological changes in the desminopathies at the earliest stage.
Huanyin Li +5 more
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Identification and validation of voltage‐dependent anion channel 1‐related genes and immune cell infiltration in diabetic nephropathy [PDF]
Journal of Diabetes Investigation, 2023 Aims/Introduction This study investigated the roles of voltage‐dependent anion channel 1‐related differentially expressed genes (VRDEGs) in diabetic nephropathy (DN).
Jiaqun Lin +6 more
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Voltage-dependent anion channel 1 (VDAC1) overexpression alleviates cardiac fibroblast activation in cardiac fibrosis via regulating fatty acid metabolism [PDF]
Redox Biology, 2023 Cardiac fibrosis is characterized by the excessive deposition of extracellular matrix in the myocardium with cardiac fibroblast activation, leading to chronic cardiac remodeling and dysfunction.
Geer Tian +8 more
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Traumatic and Diabetic Schwann Cell Demyelination Is Triggered by a Transient Mitochondrial Calcium Release through Voltage Dependent Anion Channel 1 [PDF]
Biomedicines, 2022 A large number of peripheral neuropathies, among which are traumatic and diabetic peripheral neuropathies, result from the degeneration of the myelin sheath, a process called demyelination.
Nicolas Tricaud +4 more
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Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1. [PDF]
J Biol Chem, 2017 Voltage-dependent anion channel-1 (VDAC1) is a highly regulated β-barrel membrane protein that mediates transport of ions and metabolites between the mitochondria and cytosol of the cell.
Budelier MM +10 more
europepmc +6 more sources
Expression profiling of mitochondrial voltage-dependent anion channel-1 associated genes predicts recurrence-free survival in human carcinomas. [PDF]
PLoS ONE, 2014 Mitochondrial voltage-dependent anion channels (VDACs) play a key role in mitochondria-mediated apoptosis. Both in vivo and in vitro evidences indicate that VDACs are actively involved in tumor progression.
Jae-Hong Ko +4 more
doaj +3 more sources