Results 21 to 30 of about 91,154 (289)

The mitochondrial voltage-dependent anion channel 1 in tumor cells. [PDF]

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2015
VDAC1 is found at the crossroads of metabolic and survival pathways. VDAC1 controls metabolic cross-talk between mitochondria and the rest of the cell by allowing the influx and efflux of metabolites, ions, nucleotides, Ca2+ and more.
V. Shoshan-Barmatz, Danya Ben-Hail, L. Admoni, Y. Krelin, Shambhoo Sharan Tripathi   +4 more
semanticscholar   +8 more sources

A plausible involvement of plasmalemmal voltage‐dependent anion channel 1 in the neurotoxicity of 15‐deoxy‐Δ12,14‐prostaglandin J2 [PDF]

Brain and Behavior, 2020
Introduction 15‐deoxy‐Δ12,14‐prostaglandin J2 (15d‐PGJ2) causes neuronal apoptosis independently of its nuclear receptor, peroxysome‐proliferator activated receptor γ.
Hiromi Koma, Yasuhiro Yamamoto, Noboru Okamura, Tatsurou Yagami   +3 more
doaj   +2 more sources

Multiple neurosteroid and cholesterol binding sites in voltage-dependent anion channel-1 determined by photo-affinity labeling. [PDF]

Biochim Biophys Acta Mol Cell Biol Lipids, 2019
Voltage-dependent anion channel-1 (VDAC1) is a mitochondrial porin that is implicated in cellular metabolism and apoptosis, and modulated by numerous small molecules including lipids.
Cheng WWL, Budelier MM, Sugasawa Y, Bergdoll L, Queralt-Martín M, Rosencrans W, Rostovtseva TK, Chen ZW, Abramson J, Krishnan K, Covey DF, Whitelegge JP, Evers AS.   +12 more
europepmc   +2 more sources

Peroxynitrite nitrates adenine nucleotide translocase and voltage-dependent anion channel 1 and alters their interactions and association with hexokinase II in mitochondria. [PDF]

Mitochondrion, 2019
Cardiac ischemia and reperfusion (IR) injury induces excessive emission of deleterious reactive O2 and N2 species (ROS/RNS), including the non-radical oxidant peroxynitrite (ONOO-) that can cause mitochondria dysfunction and cell death. In this study, we
Yang M, Xu Y, Heisner JS, Sun J, Stowe DF, Kwok WM, Camara AKS.   +6 more
europepmc   +2 more sources

Hypoxic-induced truncation of voltage-dependent anion channel 1 is mediated by both asparagine endopeptidase and calpain 1 activities. [PDF]

Oncotarget, 2018
The voltage-dependent anion channel 1 (VDAC1), an outer mitochondria membrane (OMM) protein, serves as a mitochondrial gatekeeper, mediating the transport of nucleotides, Ca2+ and other metabolites across the OMM.
Pahima H, Reina S, Tadmor N, Dadon-Klein D, Shteinfer-Kuzmine A, Mazure NM, De Pinto V, Shoshan-Barmatz V.   +7 more
europepmc   +2 more sources

Tripartite Motif Containing 65 Deficiency Confers Protection Against Acute Kidney Injury via Alleviating Voltage‐Dependent Anion Channel 1–Mediated Mitochondrial Dysfunction [PDF]

MedComm
Acute kidney injury (AKI) is a prevalent and serious clinical disease with a high incidence rate and significant health burden. The limited understanding of the complex pathological mechanisms has hindered the development of efficacious therapeutics ...
Tao Chen, Yang Zhang, Liting Ding, Chenlu Xiong, Chao Mei, Sisi Wei, Ming Jiang, Yingjie Huang, Jianrong Chen, Tao Xie, Qing Zhu, Qi Zhang, Xuan Huang, Shibiao Chen, Yong Li   +14 more
doaj   +2 more sources

Protocol for high-yield bacterial expression and purification of the voltage-dependent anion channel 1 for high-throughput biophysical assays [PDF]

STAR Protocols
Summary: Voltage-dependent anion channel 1 (VDAC1) is a key protein in cellular metabolism and apoptosis. Here, we present a protocol to express and purify milligram amounts of recombinant VDAC1 in Escherichia coli.
Stefano Conti Nibali, Andrea Magrì, Angela Messina, Armin Wagner, Ramona Duman, Vito De Pinto, Cristian Turato, Cristina Arrigoni, Marco Lolicato   +8 more
doaj   +2 more sources

Expression profile of mitochondrial voltage-dependent anion channel-1 (VDAC1) influenced genes is associated with pulmonary hypertension. [PDF]

Korean J Physiol Pharmacol, 2017
Several human diseases have been associated with mitochondrial voltage-dependent anion channel-1 (VDAC1) due to its role in calcium ion transportation and apoptosis.
Zhou T, Tang H, Han Y, Fraidenburg D, Kim YW, Lee D, Choi J, Bang H, Ko JH.   +8 more
europepmc   +2 more sources

Clinical implication of voltage-dependent anion channel 1 in uterine cervical cancer and its action on cervical cancer cells. [PDF]

Oncotarget, 2016
Two-dimensional gel electrophoresis and liquid chromatography-tandem mass spectrometry were performed to investigate the influence of human nonmetastatic clone 23 type 1 (nm23-H1), a metastasis-associated gene on proteomic alterations in cancer cells of ...
Wu CH, Lin YW, Wu TF, Ko JL, Wang PH.
europepmc   +2 more sources

A Single Talent Immunogenic Membrane Antigen and Novel Prognostic Predictor: voltage-dependent anion channel 1 (VDAC1) in Pancreatic Cancer. [PDF]

Sci Rep, 2016
Immunogenic membrane antigens associated with multiple biological functions of human cancer cells, have significant value in molecule diagnosis and targeted therapy. Here we screened immunogenic membrane antigens in pancreatic cancer by immunobloting IgG
Wang W, Zhang T, Zhao W, Xu L, Yang Y, Liao Q, Zhao Y.   +6 more
europepmc   +2 more sources