Results 31 to 40 of about 91,154 (289)

Voltage dependent anion channel-1 regulates death receptor mediated apoptosis by enabling cleavage of caspase-8 [PDF]

BMC Cancer, 2010
Background Activation of the extrinsic apoptosis pathway by tumour necrosis factor related apoptosis inducing ligand (TRAIL) is a novel therapeutic strategy for treating cancer that is currently under clinical evaluation.
Longley Daniel B, Paul Ian, Liberante Fabio, Chacko Alex D, Fennell Dean A   +4 more
doaj   +4 more sources

VDAC1 protein derived from extracellular vesicles promotes paclitaxel resistance in gastric cancer through autophagy and mitophagy [PDF]

Cancer Biology & Medicine
Objective: Paclitaxel (PTX), a conventional second-line therapeutic agent for advanced gastric cancer (GC), exhibits compromised clinical efficacy due to acquired chemoresistance in patients, the molecular mechanisms of which remain poorly elucidated ...
Yanna Bi, Sisi Wei, Zhe Zhang, Yuqing Wang, Yang Wen, Hongquan Wang, Kexin Li, Cong Zhang, Yumin Wang, Lianmei Zhao, Guogui Sun   +10 more
doaj   +2 more sources

Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop. [PDF]

J Biol Chem, 2014
Background: The voltage-dependent anion channel 1 (VDAC1) is identified as a receptor of human plasminogen kringle 5 (K5), but the role and mechanisms of VDAC1 in K5-induced endothelial cell (EC) apoptosis remain elusive.
Li L, Yao YC, Gu XQ, Che D, Ma CQ, Dai ZY, Li C, Zhou T, Cai WB, Yang ZH, Yang X, Gao GQ.   +11 more
europepmc   +2 more sources

Arabidopsis voltage-dependent anion channel 1 (AtVDAC1) is required for female development and maintenance of mitochondrial functions related to energy-transaction. [PDF]

PLoS ONE, 2014
The voltage-dependent anion channels (VDACs), prominently localized in the outer mitochondrial membrane, play important roles in the metabolite exchange, energy metabolism and mitochondria-mediated apoptosis process in mammalian cells.
Xiaodi Pan, Ziwei Chen, Xueyong Yang, Guoqin Liu   +3 more
doaj   +2 more sources

Mechanism of translation control of the alternative Drosophila melanogaster Voltage Dependent Anion-selective Channel 1 mRNAs [PDF]

Scientific Reports, 2018
The eukaryotic porin, also called the Voltage Dependent Anion-selective Channel (VDAC), is the main pore-forming protein of the outer mitochondrial membrane.
Loredana Leggio, F. Guarino, Andrea Magrì, R. Accardi-Gheit, S. Reina, Valeria Specchia, F. Damiano, M. Tomasello, Massimo Tommasino, A. Messina   +9 more
semanticscholar   +5 more sources

Pentenediol-Type Compounds Specifically Bind to Voltage-Dependent Anion Channel 1 in Saccharomyces cerevisiae Mitochondria.

Biochemistry, 2019
Voltage-dependent anion channel 1 (VDAC1) situated in the outer mitochondrial membrane regulates the transfer of various metabolites and is a key player in mitochondria-mediated apoptosis.
Yufu Unten, M. Murai, Takenori Yamamoto, Akira Watanabe, Naoya Ichimaru, Shunsuke Aburaya, Wataru Aoki, Y. Shinohara, H. Miyoshi   +8 more
semanticscholar   +3 more sources

The Voltage-dependent Anion Channel 1 Mediates Amyloid β Toxicity and Represents a Potential Target for Alzheimer Disease Therapy. [PDF]

J Biol Chem, 2015
Smilansky A, Dangoor L, Nakdimon I, Ben-Hail D, Mizrachi D, Shoshan-Barmatz V.   +5 more
europepmc   +2 more sources

Voltage-Dependent Anion Channel 1 Interacts with Ribonucleoprotein Complexes To Enhance Infectious Bursal Disease Virus Polymerase Activity. [PDF]

J Virol, 2017
Han C, Zeng X, Yao S, Gao L, Zhang L, Qi X, Duan Y, Yang B, Gao Y, Liu C, Zhang Y, Wang Y, Wang X.   +12 more
europepmc   +2 more sources

The voltage-dependent anion channel-1 modulates apoptotic cell death [PDF]

Cell Death & Differentiation, 2005
The role of the voltage-dependent anion channel (VDAC) in cell death was investigated using the expression of native and mutated murine VDAC1 in U-937 cells and VDAC inhibitors. Glutamate 72 in VDAC1, shown previously to bind dicyclohexylcarbodiimide (DCCD), which inhibits hexokinase isoform I (HK-I) binding to mitochondria, was mutated to glutamine ...
Hilal Zaid, Salah Abu-hamad, A. Israelson, I. Nathan, V. Shoshan-Barmatz   +4 more
semanticscholar   +3 more sources

VDAC1 (voltage-dependent anion channel 1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on VDAC1 (voltage-dependent anion channel 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Shoshan-Barmatz, V, Mizrachi, D
openaire   +2 more sources